日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Designing novel bisquinoline antimalarials from historical 4-aminoquinolines to combat drug-resistant malaria

从历史悠久的4-氨基喹啉类化合物出发,设计新型双喹啉类抗疟药以对抗耐药性疟疾

Handford, Mason J; Li, Yuexin; Riscoe, Terry; Zhang, Xiaowei; Kelly, Jane X; Riscoe, Michael K

In vivo screen of Plasmodium targets for mosquito-based malaria control

利用蚊媒控制疟疾的疟原虫靶标体内筛选

Probst, Alexandra S; Paton, Douglas G; Appetecchia, Federico; Bopp, Selina; Adams, Kelsey L; Rinvee, Tasneem A; Pou, Sovitj; Winter, Rolf; Du, Esrah W; Yahiya, Sabrina; Vidoudez, Charles; Singh, Naresh; Rodrigues, Janneth; Castañeda-Casado, Pablo; Tammaro, Chiara; Chen, Daisy; Godinez-Macias, Karla P; Jaramillo, Jasmine L; Poce, Giovanna; Rubal, Michael J; Nilsen, Aaron; Winzeler, Elizabeth A; Baum, Jake; Burrows, Jeremy N; Riscoe, Michael K; Wirth, Dyann F; Catteruccia, Flaminia

Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex

弓形虫呼吸链超复合物的结构、组装和抑制

Andrew E MacLean ,Shikha Shikha ,Mariana Ferreira Silva ,Max J Gramelspacher ,Aaron Nilsen ,Katherine M Liebman ,Sovitj Pou ,Rolf W Winter ,Amit Meir ,Michael K Riscoe ,J Stone Doggett ,Lilach Sheiner ,Alexander Mühleip

Discovery of Amodiachins, a Novel Class of 4-Aminoquinoline Antimalarials Active against Multidrug-Resistant Plasmodium falciparum

发现新型4-氨基喹啉类抗疟药Amodiachins,该类药物对多重耐药恶性疟原虫具有活性

Handford, Mason J; Li, Yuexin; Riscoe, Teresa; Liebman, Katherine M; Zhang, Xiaowei; Kelly, Jane X; Riscoe, Michael K

Enhanced Anti-Babesia Efficacy of Buparvaquone and Imidocarb When Combined with ELQ-316 In Vitro Culture of Babesia bigemina

布帕伐醌和咪唑卡与ELQ-316联合使用可增强体外培养双芽巴贝虫的抗巴贝虫疗效

Cardillo, Natalia M; Villarino, Nicolas F; Lacy, Paul A; Doggett, Joseph S; Riscoe, Michael K; Suarez, Carlos E; Ueti, Massaro W; Chung, Chungwon J

Potent Acridone Antimalarial against All Three Life Stages of Plasmodium

强效抗疟药吖啶酮,可对抗疟原虫所有三个生命阶段

Kancharla, Papireddy; Dodean, Rozalia A; Li, Yuexin; Zhang, Xiaowei; Kelly, Sean; Charlton, Jordan; Binauhan, Angley; Garcia, Laurize; Caridha, Diana; Madejczyk, Michael S; Jin, Xiannu; Dennis, William E; Kudyba, Karl; McEnearney, Sharon; Lee, Partricia J; Blount, Cameron; DeLuca, Jesse; Vuong, Chua; Pannone, Kristina; Dinh, Hieu T; Mdaki, Kennedy; Leed, Susan; Martin, Monica L; Pybus, Brandon S; Chimong, Anongruk; Cui, Liwang; Vega-Rodriguez, Joel; Okitwi, Martin; Kreutzfeld, Oriana; Docan, Christina; Green, Carol; Liu, Ying; Agulay, Aaron; Mirsalis, Jon; Farrell, Sarah N; McFadden, Geoffrey I; Goodman, Christopher D; Probst, Alexandra S; Nilsen, Aaron; Catteruccia, Flaminia; Rosenthal, Philip J; Riscoe, Michael; Cooper, Roland; Roth, Alison; Kelly, Jane

Long-acting intramuscular injections of ELQ-331, an antimalarial agent

长效肌注抗疟药ELQ-331

Karunakaran, Dipu; Mutyam, Shravan K; Fu, Melody; Chen, Jiaming; Pham, Kim Hue Nicky; Pou, Sovitj; Winter, Rolf W; Nilsen, Aaron; Dodean, Rozalia A; Smilkstein, Martin J; Riscoe, Michael K; Shankar, Gita

In artemisinin-resistant falciparum malaria parasites, mitochondrial metabolic pathways are essential for survival but not those of apicoplast

在对青蒿素产生耐药性的恶性疟原虫中,线粒体代谢途径对其生存至关重要,而顶质体代谢途径则并非如此。

Manel Ouji ,Thibaud Reyser ,Yoshiki Yamaryo-Botté ,Michel Nguyen ,David Rengel ,Axelle Dutreuil ,Marlène Marcellin ,Odile Burlet-Schiltz ,Jean-Michel Augereau ,Michael K Riscoe ,Lucie Paloque ,Cyrille Botté ,Françoise Benoit-Vical

Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis

两种新型内切辛类喹诺酮类药物ELQ-596和ELQ-650在人类巴贝虫病实验小鼠模型中的疗效

Vydyam, Pratap; Chand, Meenal; Pou, Sovitj; Winter, Rolf W; Liebman, Katherine M; Nilsen, Aaron; Doggett, J Stone; Riscoe, Michael K; Ben Mamoun, Choukri

3-Position Biaryl Endochin-like Quinolones with Enhanced Antimalarial Performance

具有增强抗疟性能的3位联芳基内切辛类喹诺酮

Pou, Sovitj; Winter, Rolf W; Dodean, Rozalia A; Liebman, Katherine; Li, Yuexin; Mather, Michael W; Nepal, Binod; Nilsen, Aaron; Handford, Mason J; Riscoe, Teresa M; Laxson, Sydney; Kirtley, Payton J; Aleshnick, Maya; Zakharov, Lev N; Kelly, Jane X; Smilkstein, Martin J; Wilder, Brandon K; Kortagere, Sandhya; Vaidya, Akhil B; Alday, P Holland; Doggett, J Stone; Riscoe, Michael K