日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeted CRISPR regulation of ZNF865 enhances stem cell cartilage deposition, tissue maturation rates, and mechanical properties in engineered intervertebral discs

利用 CRISPR 技术靶向调控 ZNF865 可增强干细胞软骨沉积、组织成熟率和工程化椎间盘的力学性能。

Levis, Hunter; Lewis, Christian; Fainor, Matthew; Lawal, Ameerah; Stockham, Elise; Weston, Jacob; Farhang, Niloofar; Gullbrand, Sarah E; Bowles, Robby D

CRISPRa genome-wide screen identifies novel gene targets for osteogenic cell engineering

CRISPRa 全基因组筛选鉴定出成骨细胞工程的新基因靶点

Weston, Jacob D; Levis, Hunter; Lawrence, Brandon; Somoza, Rodrigo; Bowles, Robby D

ZNF865 (BLST) Regulates Human Cell Senescence and DNA Damage.

ZNF865 (BLST) 调控人类细胞衰老和 DNA 损伤

Lewis Christian, Levis Hunter, Holbrook Jonah, Polaski Jacob T, Jacobsen Timothy D, Gullbrand Sarah E, Diekman Brian, Iatridis James C, Gertz Jason, Lawrence Brandon, Bowles Robby D

Therapeutic CRISPR epigenome editing of inflammatory receptors in the intervertebral disc.

利用 CRISPR 技术对椎间盘中的炎症受体进行表观基因组治疗性编辑

Stover Joshua D, Trone Matthew A R, Weston Jacob, Lewis Christian, Levis Hunter, Farhang Niloofar, Philippi Matthew, Zeidan Michelle, Lawrence Brandon, Bowles Robby D

Multiplex epigenome editing of ion channel expression in nociceptive neurons abolished degenerative IVD-conditioned media-induced mechanical sensitivity

对伤害性神经元中离子通道表达进行多重表观基因组编辑,可消除椎间盘退行性变培养基诱导的机械敏感性。

Stover, Joshua D; Trone, Matthew A; Lawrence, Brandon; Bowles, Robby D

Multiplex gene editing to promote cell survival using low-pH clustered regularly interspaced short palindromic repeats activation (CRISPRa) gene perturbation

使用低 pH 聚集规律间隔短回文重复序列激活 (CRISPRa) 基因扰动进行多重基因编辑以促进细胞存活

Hunter Levis, Jacob Weston, Brooke Austin, Bryce Larsen, Matthew Ginley-Hidinger, Sarah E Gullbrand, Brandon Lawrence, Robby D Bowles

A novel comorbidity risk score for predicting postoperative 30-day complications in total shoulder arthroplasty and elucidation of potential racial disparities

一种预测全肩关节置换术后30天并发症的新型合并症风险评分及潜在种族差异的阐明

Turk, Robby D; Li, Lambert T; Saini, Sundeep; MacAskill, Meghan; Ross, Glen; Shah, Sarav S

Degenerative IVD conditioned media and acidic pH sensitize sensory neurons to cyclic tensile strain

退变性椎间盘的条件培养基和酸性pH值会使感觉神经元对周期性拉伸应变更加敏感。

Stover, Joshua D; Lawrence, Brandon; Bowles, Robby D

Synergistic CRISPRa-Regulated Chondrogenic Extracellular Matrix Deposition Without Exogenous Growth Factors

无需外源性生长因子即可协同调控软骨生成细胞外基质沉积

Farhang, Niloofar; Davis, Bryton; Weston, Jacob; Ginley-Hidinger, Matthew; Gertz, Jason; Bowles, Robby D

Lentiviral CRISPR Epigenome Editing of Inflammatory Receptors as a Gene Therapy Strategy for Disc Degeneration

利用慢病毒CRISPR表观基因组编辑炎症受体作为椎间盘退变基因治疗策略

Farhang, Niloofar; Ginley-Hidinger, Matt; Berrett, Kristofer C; Gertz, Jason; Lawrence, Brandon; Bowles, Robby D