日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Large Library Docking for Polypharmacology

用于多药理学的大型库对接

Wu, Yujin; Vigneron, Seth; Braz, Joao; Srinivasan, Karthik; Fink, Elissa A; Huang, Xi-Ping; Xu, Xinyu; Huebner, Harald; Kim, Joseph Y; Wang, Jing; Pfeiffer, Tara; Sakamoto, Kensuke; Radchenko, Dmytro S; Rodriguiz, Ramona M; Moroz, Yurii S; Irwin, John J; Gmeiner, Peter; Billesboelle, Christian; Roth, Bryan L; Basbaum, Allan I; Manglik, Aashish; Wetsel, William C; Shoichet, Brian K

Electrical stimulation of the vagus nerve improves amyloid pathology in delirium superimposed on dementia.

迷走神经电刺激可改善痴呆症合并谵妄中的淀粉样蛋白病理。

Song Chengcheng, Wu Pau Yen, Huffman William J, David-Bercholz Jennifer, Bedolla Alicia, Velagapudi Ravikanth, Njoroge Ann, Rodriguiz Ramona M, Wetsel William C, Rendina Danielle, Bilbo Staci D, Chiang Wesley, Ogu Jessica C, Gelbard Harris A, Yang Ting, Grill Warren M, Terrando Niccolò

Structure-based discovery of conformationally selective inhibitors of the serotonin transporter

基于结构发现血清素转运蛋白的构象选择性抑制剂

Isha Singh, Anubha Seth, Christian B Billesbølle, Joao Braz, Ramona M Rodriguiz, Kasturi Roy, Bethlehem Bekele, Veronica Craik, Xi-Ping Huang, Danila Boytsov, Vladimir M Pogorelov, Parnian Lak, Henry O'Donnell, Walter Sandtner, John J Irwin, Bryan L Roth, Allan I Basbaum, William C Wetsel, Aashish M

Rescue of glutaric aciduria type I in mice by liver-directed therapies

通过肝脏靶向疗法挽救小鼠戊二酸尿症 I 型

Mercedes Barzi ,Collin G Johnson ,Tong Chen ,Ramona M Rodriguiz ,Madeline Hemmingsen ,Trevor J Gonzalez ,Alan Rosales ,James Beasley ,Cheryl K Peck ,Yunhan Ma ,Ashlee R Stiles ,Timothy C Wood ,Raquel Maeso-Diaz ,Anna Mae Diehl ,Sarah P Young ,Jeffrey I Everitt ,William C Wetsel ,William R Lagor ,Beatrice Bissig-Choisat ,Aravind Asokan ,Areeg El-Gharbawy ,Karl-Dimiter Bissig

The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice

蛋白偏向血清素 5-HT2A 受体激动剂利舒利在小鼠中发挥抗抑郁药物样活性

Vladimir M Pogorelov, Ramona M Rodriguiz, Bryan L Roth, William C Wetsel

The G protein biased serotonin 5-HT 2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice

G蛋白偏向性5-羟色胺5-HT2A受体激动剂利舒脲在小鼠体内发挥抗抑郁药物样活性

Pogorelov, Vladimir M; Rodriguiz, Ramona M; Roth, Bryan L; Wetsel, William C

Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity

针对具有抗抑郁活性的5-HT2A受体激动剂的定制化化合物库对接

Anat Levit Kaplan #,Danielle N Confair #,Kuglae Kim #,Ximena Barros-Álvarez #,Ramona M Rodriguiz,Ying Yang,Oh Sang Kweon,Tao Che,John D McCorvy,David N Kamber,James P Phelan,Luan Carvalho Martins,Vladimir M Pogorelov,Jeffrey F DiBerto,Samuel T Slocum,Xi-Ping Huang,Jain Manish Kumar,Michael J Robertson,Ouliana Panova,Alpay B Seven,Autumn Q Wetsel,William C Wetsel,John J Irwin,Georgios Skiniotis,Brian K Shoichet,Bryan L Roth,Jonathan A Ellman

Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome

膜联蛋白 A1 三肽通过调节 NLRP3 炎症小体减轻手术引起的神经炎症和记忆缺陷

Zhiquan Zhang, Qing Ma, Ravikanth Velagapudi, William E Barclay, Ramona M Rodriguiz, William C Wetsel, Ting Yang, Mari L Shinohara, Niccolò Terrando

Identification and Characterization of ML321: A Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity

ML321 的鉴别和表征:一种新型高选择性 D2 多巴胺受体拮抗剂,在预测非典型抗精神病活性的动物模型中具有疗效

R Benjamin Free, Ashley N Nilson, Noelia M Boldizsar, Trevor B Doyle, Ramona M Rodriguiz, Vladimir M Pogorelov, Mayako Machino, Kuo Hao Lee, Jeremiah W Bertz, Jinbin Xu, Herman D Lim, Andrés E Dulcey, Robert H Mach, James H Woods, J Robert Lane, Lei Shi, Juan J Marugan, William C Wetsel, David R Sib

Conserved YKL-40 changes in mice and humans after postoperative delirium

术后谵妄后小鼠和人类的 YKL-40 变化

Jennifer David-Bercholz, Leah Acker, Ana I Caceres, Pau Yen Wu, Saanvi Goenka, Nathan O Franklin, Ramona M Rodriguiz, William C Wetsel, Michael Devinney, Mary Cooter Wright, Henrik Zetterberg, Ting Yang, Miles Berger, Niccolò Terrando