日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent

脱靶体外分析表明瑞德西韦是一种高选择性抗病毒药物

Yili Xu, Ona Barauskas, Cynthia Kim, Darius Babusis, Eisuke Murakami, Dmytro Kornyeyev, Gary Lee, George Stepan, Michel Perron, Roy Bannister, Brian E Schultz, Roman Sakowicz, Danielle Porter, Tomas Cihlar, Joy Y Feng

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

参与瑞德西韦在人肺细胞中激活的关键代谢酶

Ruidong Li #, Albert Liclican #, Yili Xu, Jared Pitts, Congrong Niu, Jingyu Zhang, Cynthia Kim, Xiaofeng Zhao, Daniel Soohoo, Darius Babusis, Qin Yue, Bin Ma, Bernard P Murray, Raju Subramanian, Xuping Xie, Jing Zou, John P Bilello, Li Li, Brian E Schultz, Roman Sakowicz, Bill J Smith, Pei-Yong Shi,

Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9

人类 MMP9 强效选择性抗体抑制剂的生化表征和结构测定

Todd C Appleby, Andrew E Greenstein, Magdeleine Hung, Albert Liclican, Maile Velasquez, Armando G Villaseñor, Ruth Wang, Melanie H Wong, Xiaohong Liu, Giuseppe A Papalia, Brian E Schultz, Roman Sakowicz, Victoria Smith, Hyock Joo Kwon

Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus

线粒体 RNA 聚合酶在丙型肝炎病毒核苷酸抑制剂毒性中的作用

Joy Y Feng, Yili Xu, Ona Barauskas, Jason K Perry, Shekeba Ahmadyar, George Stepan, Helen Yu, Darius Babusis, Yeojin Park, Krista McCutcheon, Michel Perron, Brian E Schultz, Roman Sakowicz, Adrian S Ray

Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells

非催化位点 HIV-1 整合酶抑制剂破坏核心成熟并诱导靶细胞逆转录阻断

Mini Balakrishnan, Stephen R Yant, Luong Tsai, Christopher O'Sullivan, Rujuta A Bam, Angela Tsai, Anita Niedziela-Majka, Kirsten M Stray, Roman Sakowicz, Tomas Cihlar

Large-scale functional purification of recombinant HIV-1 capsid

重组 HIV-1 衣壳的大规模功能纯化

Magdeleine Hung, Anita Niedziela-Majka, Debi Jin, Melanie Wong, Stephanie Leavitt, Katherine M Brendza, Xiaohong Liu, Roman Sakowicz

New class of HIV-1 integrase (IN) inhibitors with a dual mode of action

具有双重作用模式的新型 HIV-1 整合酶 (IN) 抑制剂

Manuel Tsiang, Gregg S Jones, Anita Niedziela-Majka, Elaine Kan, Eric B Lansdon, Wayne Huang, Magdeleine Hung, Dharmaraj Samuel, Nikolai Novikov, Yili Xu, Michael Mitchell, Hongyan Guo, Kerim Babaoglu, Xiaohong Liu, Romas Geleziunas, Roman Sakowicz

The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function

HCV 非核苷抑制剂 Tegobuvir 采用新的作用机制来抑制 NS5B 聚合酶功能

Christy M Hebner, Bin Han, Katherine M Brendza, Michelle Nash, Maisoun Sulfab, Yang Tian, Magdeleine Hung, Wanchi Fung, Randall W Vivian, James Trenkle, James Taylor, Kyla Bjornson, Steven Bondy, Xiaohong Liu, John Link, Johan Neyts, Roman Sakowicz, Weidong Zhong, Hengli Tang, Uli Schmitz

Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex

HIV-1 整合酶二聚体-晶状体上皮衍生生长因子 (IN 二聚体-LEDGF) 复合物结合伙伴之间的亲和力

Manuel Tsiang, Gregg S Jones, Magdeleine Hung, Susmith Mukund, Bin Han, Xiaohong Liu, Kerim Babaoglu, Eric Lansdon, Xiaowu Chen, Jacob Todd, Terrence Cai, Nikos Pagratis, Roman Sakowicz, Romas Geleziunas

Mechanism of inhibition of human KSP by ispinesib

ispinesib 抑制人类 KSP 的机制

Latesh Lad, Lusong Luo, Jeffrey D Carson, Kenneth W Wood, James J Hartman, Robert A Copeland, Roman Sakowicz