日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture

化学-遗传相互作用矩阵揭示药物机制和遗传结构

Coulombe-Huntington, Jasmin; Bertomeu, Thierry; Huard, Caroline; Chatr-Aryamontri, Andrew; St-Cyr, Daniel J; Sánchez-Osuna, María; Papadopoli, David; Normandin, Karine; Paydar, Mohammadjavad; McLaughlan, Shannon; St-Denis, Corinne; Zhang, Li; Say, Henry; Palou, Roger; Stark, Chris; Breitkreutz, Bobby-Joe; van der Sloot, Almer M; Manohar, Sandhya; Lavoie, Hugo; Borden, Katherine L B; Raught, Brian; D'Amours, Damien; Sicheri, Frank; Verreault, Alain; Mader, Sylvie; Meloche, Sylvain; Therrien, Marc; Thibault, Pierre; Wilhelm, Brian; Dirks, Peter B; Aitchison, John D; Patton, Elizabeth; King, Randall W; Roux, Philippe P; Sauvageau, Guy; Hoang, Trang; Marinier, Anne; Harrington, Lea; Kwok, Benjamin; Archambault, Vincent; Topisirovic, Ivan; Tyers, Mike

mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport.

mTOR抑制剂通过诱导替代脂质摄取和促进胆固醇转运来重编程细胞脂质稳态。

Shin Sejeong, Han Min-Joon, Patel Ishika, Welsh Alia M, Sverdlov Maria, Cho Wonhwa, Cologna Stephanie M, Roux Philippe P, Yoon Sang-Oh

IL1RAP is an immunotherapeutic target for normal karyotype triple-mutated acute myeloid leukemia.

IL1RAP 是正常核型三突变急性髓系白血病的免疫治疗靶点

Métois Arnaud, Bordeleau Marie-Eve, Theret Louis, Hajmirza Azadeh, Moujaber Ossama, Spinella Jean-François, Chagraoui Jalila, Mayotte Nadine, Boivin Isabel, Audemard Éric, Aubert Léo, Lisi Véronique, Khakipoor Banafsheh, Farah Azer, Bonneil Éric, Robert Alma, Lippens Julie, Moraitis Anna, Béliveau François, Feghaly Albert, Boucher Geneviève, Marcotte Richard, Gendron Patrick, Thibault Pierre, Lemieux Sébastien, Richard-Carpentier Guillaume, Lavallée Vincent-Philippe, Hébert Josée, Roux Philippe P, Sauvageau Guy

14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation.

14-3-3ζ 通过在脂肪细胞分化的早期阶段调节染色质可及性来促进脂肪生成

Rial Sabri A, You Zhipeng, Vivoli Alexis, Paré Fédéric, Sean Daphné, AlKhoury Amal, Lavoie Geneviève, Civelek Mete, Martinez-Sanchez Aida, Roux Philippe P, Durcan Thomas M, Lim Gareth E

CDK11 activates CDK12 to trigger the elongation of RNA Polymerase II

CDK11激活CDK12,从而触发RNA聚合酶II的延伸。

Liu, Haolin; Li, Lingbo; Gao, Junfeng; Leach, Sonia; Wei, Pengcheng; Zhang, Qianqian; Huang, Hua; Houles, Thibault; Roux, Philippe P; Zhang, Gongyi

Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

作者更正:体内 CRISPR 筛选揭示 Serpinb9 和 Adam2 是肺癌免疫治疗反应的调节因子

Dervovic, Dzana; Malik, Ahmad A; Chen, Edward L Y; Narimatsu, Masahiro; Adler, Nina; Afiuni-Zadeh, Somaieh; Krenbek, Dagmar; Martinez, Sebastien; Tsai, Ricky; Boucher, Jonathan; Berman, Jacob M; Teng, Katie; Ayyaz, Arshad; Lü, YiQing; Mbamalu, Geraldine; Loganathan, Sampath K; Lee, Jongbok; Zhang, Li; Guidos, Cynthia; Wrana, Jeffrey; Valipour, Arschang; Roux, Philippe P; Reimand, Jüri; Jackson, Hartland W; Schramek, Daniel

Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation

甘油三酯衍生的脂肪酸可降低视网膜血管瘤增殖模型中的自噬作用

Heckel, Emilie; Cagnone, Gael; Agnihotri, Tapan; Cakir, Bertan; Das, Ashim; Kim, Jin Sung; Kim, Nicholas; Lavoie, Geneviève; Situ, Anu; Pundir, Sheetal; Sun, Ye; Wünnemann, Florian; Pierce, Kerry A; Dennis, Courtney; Mitchell, Grant A; Chemtob, Sylvain; Rezende, Flavio A; Andelfinger, Gregor; Clish, Clary B; Roux, Philippe P; Sapieha, Przemyslaw; Smith, Lois Eh; Joyal, Jean-Sébastien

Controversies around the function of LARP1

围绕LARP1功能的争议

Berman, Andrea J; Thoreen, Carson C; Dedeic, Zinaida; Chettle, James; Roux, Philippe P; Blagden, Sarah P

Targeting copper metabolism to defeat KRAS-driven colorectal cancer

靶向铜代谢以对抗KRAS驱动的结直肠癌

Aubert, Léo; Nandagopal, Neethi; Roux, Philippe P

ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation

ERK2通过DOCK10依赖的Rac1/FoxO1激活来调控上皮-间质可塑性。

Shin, Sejeong; Buel, Gwen R; Nagiec, Michal J; Han, Min-Joon; Roux, Philippe P; Blenis, John; Yoon, Sang-Oh