日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions

冷冻电镜揭示了RNA聚合酶I在无碱基DNA损伤处暂停和停滞的顺序机制

Santos-Aledo, Alicia; Plaza-Pegueroles, Adrián; Sanz-Murillo, Marta; Ruiz, Federico M; Hou, Peini; Xu, Jun; Gil-Carton, David; Wang, Dong; Fernández-Tornero, Carlos

The cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase provides mechanistic and dynamic insights into its enzymatic function.

锥虫 3-甲基巴豆酰辅酶A羧化酶的冷冻电镜结构提供了对其酶功能的机制和动态见解

Plaza-Pegueroles Adrián, Aphasizheva Inna, Aphasizhev Ruslan, Fernández-Tornero Carlos, Ruiz Federico M

Small-molecule MMRi36 induces apoptosis in p53-mutant lymphomas by targeting MDM2/MDM4/XIAP for degradation.

小分子 MMRi36 通过靶向 MDM2/MDM4/XIAP 进行降解,诱导 p53 突变淋巴瘤细胞凋亡

Lama Rati, Wu Wenjie, Mavis Cory K, Ruiz Federico M, Querol-García Javier, Martin Diana, Chemler Sherry R, Chandra Dhyan, Goodrich David W, Hernandez-Ilizaliturri Francisco J, Muñoz Inés G, Wang Xinjiang

Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status

小分子MMRi62靶向MDM4使其降解,并诱导白血病细胞凋亡,且该作用不受p53状态的影响。

Lama, Rati; Xu, Chao; Galster, Samuel L; Querol-García, Javier; Portwood, Scott; Mavis, Cory K; Ruiz, Federico M; Martin, Diana; Wu, Jin; Giorgi, Marianna C; Bargonetti, Jill; Wang, Eunice S; Hernandez-Ilizaliturri, Francisco J; Koudelka, Gerald B; Chemler, Sherry R; Muñoz, Inés G; Wang, Xinjiang

Structural Characterization of TssL from Acinetobacter baumannii: a Key Component of the Type VI Secretion System

鲍曼不动杆菌TssL的结构表征:VI型分泌系统的关键组分

Ruiz, Federico M; Lopez, Juvenal; Ferrara, C Gastón; Santillana, Elena; Espinosa, Yanis R; Feldman, Mario F; Romero, Antonio

Galectin-related protein: An integral member of the network of chicken galectins 1. From strong sequence conservation of the gene confined to vertebrates to biochemical characteristics of the chicken protein and its crystal structure

半乳糖凝集素相关蛋白:鸡半乳糖凝集素网络的重要组成部分 1. 从仅限于脊椎动物的基因序列高度保守性到鸡蛋白的生化特性及其晶体结构

García Caballero, Gabriel; Flores-Ibarra, Andrea; Michalak, Malwina; Khasbiullina, Nailya; Bovin, Nicolai V; André, Sabine; Manning, Joachim C; Vértesy, Sabine; Ruiz, Federico M; Kaltner, Herbert; Kopitz, Jürgen; Romero, Antonio; Gabius, Hans-Joachim

Crystal Structure of Hcp from Acinetobacter baumannii: A Component of the Type VI Secretion System

鲍曼不动杆菌Hcp的晶体结构:VI型分泌系统的组成部分

Ruiz, Federico M; Santillana, Elena; Spínola-Amilibia, Mercedes; Torreira, Eva; Culebras, Esther; Romero, Antonio

The binding of triclosan to SmeT, the repressor of the multidrug efflux pump SmeDEF, induces antibiotic resistance in Stenotrophomonas maltophilia

三氯生与多药外排泵SmeDEF的阻遏蛋白SmeT结合,可诱导嗜麦芽窄食单胞菌产生抗生素耐药性。

Hernández, Alvaro; Ruiz, Federico M; Romero, Antonio; Martínez, José L