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日期影响因子

Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization

结构多样的 6-芳基-3-芳酰基吲哚类似物作为微管蛋白聚合抑制剂的合成及生物学评价

期刊:European Journal of Medicinal Chemistry

doi:10.1016/j.ejmech.2023.115794

Wen Ren, Yuling Deng, Jacob D Ward, Rebecca Vairin, Ruoli Bai, Hashini I Wanniarachchi, Khagendra B Hamal, Pouguiniseli E Tankoano, Caleb S Tamminga, Lorena M A Bueno, Ernest Hamel, Ralph P Mason, Mary Lynn Trawick, Kevin G Pinney4

发表日期：2024

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Are the metal identity and stoichiometry of metal complexes important for colchicine site binding and inhibition of tubulin polymerization?

金属配合物的金属特性和化学计量对于秋水仙碱位点结合和抑制微管蛋白聚合是否重要？

期刊:Dalton Transactions

影响因子:3.5

doi:10.1039/d4dt01469c

Iuliana Besleaga, Renáta Raptová, Alexandru-Constantin Stoica, Miljan N M Milunovic, Michal Zalibera, Ruoli Bai, Nóra Igaz, Jóhannes Reynisson, Mónika Kiricsi, Éva A Enyedy, Peter Rapta, Ernest Hamel, Vladimir B Arion

发表日期：2024

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4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1 H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells

4-(3-苯基-4-(3,4,5-三甲氧基苯甲酰)-1 H-吡咯-1-基)苯磺酰胺，一种新型碳酸酐酶和 Wnt/β-Catenin 信号通路双靶向抑制剂，对多药耐药癌细胞具有强效活性

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.3c01424

Domiziana Masci, Michela Puxeddu, Laura Di Magno, Michele D'Ambrosio, Anastasia Parisi, Marianna Nalli, Ruoli Bai, Antonio Coluccia, Pietro Sciò, Viviana Orlando, Sara D'Angelo, Stefano Biagioni, Andrea Urbani, Ernest Hamel, Alessio Nocentini, Serena Filiberti, Marta Turati, Roberto Ronca, Joanna Ko

发表日期：2023

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Indolo[2,3- e]benzazocines and indolo[2,3- f]benzazonines and their copper(II) complexes as microtubule destabilizing agents

吲哚[2,3-e]苯并唑啉和吲哚[2,3-f]苯并唑啉及其铜(II)配合物作为微管不稳定剂

期刊:Dalton Transactions

影响因子:3.5

doi:10.1039/d3dt01632c

Christopher Wittmann, Orsolya Dömötör, Irina Kuznetcova, Gabriella Spengler, Jóhannes Reynisson, Lauren Holder, Gavin J Miller, Eva A Enyedy, Ruoli Bai, Ernest Hamel, Vladimir B Arion

发表日期：2023

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Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor

新型吡咯微管蛋白组装抑制剂诱导胶质母细胞瘤和卵巢癌中的铁死亡

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.2c01457

Michela Puxeddu, Jianchao Wu, Ruoli Bai, Michele D'Ambrosio, Marianna Nalli, Antonio Coluccia, Simone Manetto, Alessia Ciogli, Domiziana Masci, Andrea Urbani, Cinzia Fionda, Sonia Coni, Rosa Bordone, Gianluca Canettieri, Chiara Bigogno, Giulio Dondio, Ernest Hamel, Te Liu, Romano Silvestri, Giuseppe

细胞生物学

发表日期：2022

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Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities

源自海洋生物碱 Rigidins 的新型微管靶向 7-脱氮次黄嘌呤，具有强效的体外和体内抗癌活性

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.5b01426

Derek C Medellin, Qiong Zhou, Robert Scott, R Matthew Hill, Sarah K Frail, Ramesh Dasari, Steven J Ontiveros, Stephen C Pelly, Willem A L van Otterlo, Tania Betancourt, Charles B Shuster, Ernest Hamel, Ruoli Bai, Daniel V LaBarbera, Snezna Rogelj, Liliya V Frolova, Alexander Kornienko

发表日期：2016

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New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer

新的吲哚微管蛋白组装抑制剂可稳定阻止有丝分裂进程、增强自然杀伤细胞的细胞毒活性并抑制 Hedgehog 依赖性癌症

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.5b00310

Giuseppe La Regina, Ruoli Bai, Antonio Coluccia, Valeria Famiglini, Sveva Pelliccia, Sara Passacantilli, Carmela Mazzoccoli, Vitalba Ruggieri, Annalisa Verrico, Andrea Miele, Ludovica Monti, Marianna Nalli, Romina Alfonsi, Lucia Di Marcotullio, Alberto Gulino, Biancamaria Ricci, Alessandra Soriani,

自然杀伤细胞

发表日期：2015

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Synthesis, antiproliferative activity and possible mechanism of action of novel 2-acetamidobenzamides bearing the 2-phenoxy functionality

具有 2-苯氧基官能团的新型 2-乙酰氨基苯甲酰胺的合成、抗增殖活性和可能的作用机制

期刊:Bioorganic & Medicinal Chemistry

影响因子:3.3

doi:10.1016/j.bmc.2015.08.027

Demetrio Raffa, Benedetta Maggio, Fabiana Plescia, Stella Cascioferro, Maria Valeria Raimondi, Gabriella Cancemi, Antonella D'Anneo, Marianna Lauricella, Maria Grazia Cusimano, Ruoli Bai, Ernest Hamel, Giuseppe Daidone

发表日期：2015

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New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer

具有强效微管蛋白聚合抑制活性的新型吡咯衍生物可作为抗癌剂，包括针对刺猬依赖性癌症的药物

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/jm500561a

Giuseppe La Regina, Ruoli Bai, Antonio Coluccia, Valeria Famiglini, Sveva Pelliccia, Sara Passacantilli, Carmela Mazzoccoli, Vitalba Ruggieri, Lorenza Sisinni, Alessio Bolognesi, Whilelmina Maria Rensen, Andrea Miele, Marianna Nalli, Romina Alfonsi, Lucia Di Marcotullio, Alberto Gulino, Andrea Branc

发表日期：2014

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Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors

通过调节芳硫吲哚类微管蛋白聚合抑制剂的 C-2 基团，开发出高效抗癌药物

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/jm3013097

Giuseppe La Regina, Ruoli Bai, Whilelmina Maria Rensen, Erica Di Cesare, Antonio Coluccia, Francesco Piscitelli, Valeria Famiglini, Alessia Reggio, Marianna Nalli, Sveva Pelliccia, Eleonora Da Pozzo, Barbara Costa, Ilaria Granata, Amalia Porta, Bruno Maresca, Alessandra Soriani, Maria Luisa Iannitto

发表日期：2013

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