日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL

TFIIH 的药物靶向作用可抑制 KRAS 突变型胰腺导管腺癌并与 TRAIL 产生协同作用

Russell Moser, James Annis, Olga Nikolova, Cliff Whatcott, Kay Gurley, Eduardo Mendez, Kim Moran-Jones, Craig Dorrell, Rosalie C Sears, Calvin Kuo, Haiyong Han, Andrew Biankin, Carla Grandori, Daniel D Von Hoff, Christopher J Kemp

Targeting BET Proteins BRD2 and BRD3 in Combination with PI3K-AKT Inhibition as a Therapeutic Strategy for Ovarian Clear Cell Carcinoma

以 BET 蛋白 BRD2 和 BRD3 为靶点,联合 PI3K-AKT 抑制作为卵巢透明细胞癌的治疗策略

Shogo Shigeta, Goldie Y L Lui, Reid Shaw, Russell Moser, Kay E Gurley, Grace Durenberger, Rachele Rosati, Robert L Diaz, Tan A Ince, Elizabeth M Swisher, Carla Grandori, Christopher J Kemp

Functional kinomics identifies candidate therapeutic targets in head and neck cancer

功能动力学组学确定头颈癌的候选治疗靶点

Russell Moser, Chang Xu, Michael Kao, James Annis, Luisa Angelica Lerma, Christopher M Schaupp, Kay E Gurley, In Sock Jang, Asel Biktasova, Wendell G Yarbrough, Adam A Margolin, Carla Grandori, Christopher J Kemp, Eduardo Méndez

MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency

MYC 驱动的肿瘤发生受到 WRN 综合征基因缺陷的抑制

Russell Moser, Masafumi Toyoshima, Kristin Robinson, Kay E Gurley, Heather L Howie, Jerry Davison, Martin Morgan, Christopher J Kemp, Carla Grandori

DNA-PK suppresses a p53-independent apoptotic response to DNA damage

DNA-PK 抑制 p53 独立的 DNA 损伤引起的细胞凋亡反应

Kay E Gurley, Russell Moser, Yansong Gu, Paul Hasty, Christopher J Kemp

p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability

p27kip1 缺乏会损害 DNA 损伤引起的 G2/M 停滞,从而导致遗传不稳定性增加

Shannon R Payne, Shulin Zhang, Karen Tsuchiya, Russell Moser, Kay E Gurley, Gary Longton, Johan deBoer, Christopher J Kemp