日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of New KCNT1-Epilepsy Drugs by In Silico, Cell, and Drosophila Modeling

利用计算机模拟、细胞和果蝇模型鉴定新的KCNT1癫痫药物

Ricos, Michael G; Cole, Bethan A; Hussain, Rashid; Rychkov, Grigori Y; Shaukat, Zeeshan; Pilati, Nadia; Muench, Stephen P; Simmons, Katie J; Dibbens, Leanne M; Lippiat, Jonathan D

Splanchnic and Pelvic Spinal Afferent Pathways Relay Sensory Information From the Mouse Colorectum Into Distinct Brainstem Circuits

内脏和盆腔脊髓传入通路将小鼠结直肠的感觉信息传递到不同的脑干回路

Wang, QingQing; McGovern, Alice E; Kyloh, Melinda; Rychkov, Grigori; Spencer, Nick J; Mazzone, Stuart B; Brierley, Stuart M; Harrington, Andrea M

Non-trivial Fixed Point of a ψd4 Fermionic Theory, II: Anomalous Exponent and Scaling Operators

ψd4 费米子理论的非平凡不动点,II:反常指数算符和标度算符

Giuliani, Alessandro; Mastropietro, Vieri; Rychkov, Slava; Scola, Giuseppe

Single-cell RNA-Seq analysis reveals cell subsets and gene signatures associated with rheumatoid arthritis disease activity

单细胞RNA测序分析揭示了与类风湿性关节炎疾病活动相关的细胞亚群和基因特征。

Binvignat, Marie; Miao, Brenda Y; Wibrand, Camilla; Yang, Monica M; Rychkov, Dmitry; Flynn, Emily; Nititham, Joanne; Tamaki, Whitney; Khan, Umair; Carvidi, Alexander; Krueger, Melissa; Niemi, Erene; Sun, Yang; Fragiadakis, Gabriela K; Sellam, Jérémie; Mariotti-Ferrandiz, Encarnita; Klatzmann, David; Gross, Andrew J; Ye, Chun Jimmie; Butte, Atul J; Criswell, Lindsey A; Nakamura, Mary C; Sirota, Marina

Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy

表达突变人类 KCNT1 转基因的果蝇成为 KCNT1 癫痫整体动物模型中靶向药物筛选的有效工具

Rashid Hussain, Chiao Xin Lim, Zeeshan Shaukat, Anowarul Islam, Emily A Caseley, Jonathan D Lippiat, Grigori Y Rychkov, Michael G Ricos, Leanne M Dibbens

Potential Binding Sites of Pharmacological Chaperone NCGC00241607 on Mutant β-Glucocerebrosidase and Its Efficacy on Patient-Derived Cell Cultures in Gaucher and Parkinson's Disease

药理学伴侣 NCGC00241607 在突变型 β-葡糖脑苷脂酶上的潜在结合位点及其对戈谢病和帕金森病患者来源细胞培养物的疗效

Alena E Kopytova ,George N Rychkov ,Alexander A Cheblokov ,Elena V Grigor'eva ,Mikhail A Nikolaev ,Elena S Yarkova ,Diana A Sorogina ,Farid M Ibatullin ,Galina V Baydakova ,Artem D Izyumchenko ,Daria A Bogdanova ,Vitali M Boitsov ,Akim V Rybakov ,Irina V Miliukhina ,Vadim A Bezrukikh ,Galina N Salogub ,Ekaterina Y Zakharova ,Sofya N Pchelina ,Anton K Emelyanov

Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors

FSGS相关循环因子诱导的足细胞转录组和生物学通路紊乱

Rashmi, Priyanka; Sigdel, Tara K; Rychkov, Dmitry; Damm, Izabella; Da Silva, Andrea Alice; Vincenti, Flavio; Lourenco, Andre L; Craik, Charles S; Reiser, Jochen; Sarwal, Minnie M

Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination

泛疫苗分析揭示了可预测疫苗接种抗体反应的先天免疫内型

Fourati, Slim; Tomalin, Lewis E; Mulè, Matthew P; Chawla, Daniel G; Gerritsen, Bram; Rychkov, Dmitry; Henrich, Evan; Miller, Helen E R; Hagan, Thomas; Diray-Arce, Joann; Dunn, Patrick; Levy, Ofer; Gottardo, Raphael; Sarwal, Minnie M; Tsang, John S; Suárez-Fariñas, Mayte; Pulendran, Bali; Kleinstein, Steven H; Sékaly, Rafick-Pierre

Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses

对13种疫苗的人类免疫反应转录组图谱分析揭示了疫苗诱导抗体反应的共同预测因子

Hagan, Thomas; Gerritsen, Bram; Tomalin, Lewis E; Fourati, Slim; Mulè, Matthew P; Chawla, Daniel G; Rychkov, Dmitri; Henrich, Evan; Miller, Helen E R; Diray-Arce, Joann; Dunn, Patrick; Lee, Audrey; Levy, Ofer; Gottardo, Raphael; Sarwal, Minne M; Tsang, John S; Suárez-Fariñas, Mayte; Sékaly, Rafick-Pierre; Kleinstein, Steven H; Pulendran, Bali

Ubr1-induced selective endophagy/autophagy protects against the endosomal and Ca2+-induced proteostasis disease stress

Ubr1 诱导的选择性内吞/自噬可抵御内体和 Ca2+ 诱导的蛋白质稳态疾病应激

Ben B Wang, Haijin Xu, Sandra Isenmann, Cheng Huang, Xabier Elorza-Vidal, Grigori Y Rychkov, Raúl Estévez, Ralf B Schittenhelm, Gergely L Lukacs, Pirjo M Apaja3