日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome.

γ-分泌酶调节剂 BPN15606 降低了 Aβ42 和 Aβ40，并对抗了唐氏综合征小鼠模型中的阿尔茨海默病相关病理

期刊:Annals of Neurology
影响因子:7.7
doi:10.1002/ana.26958
Chen Xu-Qiao, Becker Ann, Albay Ricardo, Nguyen Phuong D, Karachentsev Dmitry, Roberts Amanda J, Rynearson Kevin D, Tanzi Rudolph E, Mobley William C
其它
Mouse
发表日期：2024
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Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention

用于预防阿尔茨海默病的强效γ-分泌酶调节剂的临床前验证

期刊:Journal of Experimental Medicine
影响因子:10.6
doi:10.1084/jem.20202560
Rynearson, Kevin D; Ponnusamy, Moorthi; Prikhodko, Olga; Xie, Yuhuan; Zhang, Can; Nguyen, Phuong; Hug, Brenda; Sawa, Mariko; Becker, Ann; Spencer, Brian; Florio, Jazmin; Mante, Michael; Salehi, Bahar; Arias, Carlos; Galasko, Douglas; Head, Brian P; Johnson, Graham; Lin, Jiunn H; Duddy, Steven K; Rissman, Robert A; Mobley, William C; Thinakaran, Gopal; Tanzi, Rudolph E; Wagner, Steven L
阿尔茨海默症
发表日期：2021
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Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates

小鼠和非人灵长类动物中阿尔茨海默病相关γ-分泌酶的分子成像

期刊:Journal of Experimental Medicine
影响因子:10.6
doi:10.1084/jem.20182266
Xu, Yulong; Wang, Changning; Wey, Hsiao-Ying; Liang, Yingxia; Chen, Zude; Choi, Se Hoon; Ran, Chongzhao; Rynearson, Kevin D; Bernales, Daniela R; Koegel, Robert E; Fiedler, Stephanie A; Striar, Robin; Wagner, Steven L; Tanzi, Rudolph E; Zhang, Can
阿尔茨海默症
发表日期：2020
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γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion

γ-分泌酶直接插入脂质双层后，会重塑膜微区。

期刊:Langmuir
影响因子:3.9
doi:10.1021/acs.langmuir.0c01178
Barros, Marilia; Houlihan, William J; Paresi, Chelsea J; Brendel, Matthew; Rynearson, Kevin D; Lee, Chang-Wook; Prikhodko, Olga; Cregger, Cristina; Chang, Geoffrey; Wagner, Steven L; Gilchrist, M Lane; Li, Yue-Ming
发表日期：2020
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Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.

新型甲氧基吡啶衍生的γ-分泌酶调节剂的设计与合成

期刊:Bioorganic & Medicinal Chemistry
影响因子:3
doi:10.1016/j.bmc.2020.115734
Rynearson Kevin D, Buckle Ronald N, Herr R Jason, Mayhew Nicholas J, Chen Xinchao, Paquette William D, Sakwa Samuel A, Yang Jinhai, Barnes Keith D, Nguyen Phuong, Mobley William C, Johnson Graham, Lin Juinn H, Tanzi Rudolph E, Wagner Steven L
免疫/内分泌
发表日期：2020
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Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606

强效口服γ-分泌酶调节剂BPN-15606的药理学和毒理学特性

期刊:Journal of Pharmacology and Experimental Therapeutics
影响因子:3.8
doi:10.1124/jpet.117.240861
Wagner, Steven L; Rynearson, Kevin D; Duddy, Steven K; Zhang, Can; Nguyen, Phuong D; Becker, Ann; Vo, Uyen; Masliah, Deborah; Monte, Louise; Klee, Justin B; Echmalian, Corinne M; Xia, Weiming; Quinti, Luisa; Johnson, Graham; Lin, Jiunn H; Kim, Doo Y; Mobley, William C; Rissman, Robert A; Tanzi, Rudolph E
发表日期：2017
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Nanopore-based conformational analysis of a viral RNA drug target

基于纳米孔的病毒RNA药物靶标构象分析

期刊:ACS Nano
影响因子:16
doi:10.1021/nn501969r
Shasha, Carolyn; Henley, Robert Y; Stoloff, Daniel H; Rynearson, Kevin D; Hermann, Thomas; Wanunu, Meni
微生物学
发表日期：2014
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Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site

靶向内部核糖体进入位点的丙型肝炎病毒翻译抑制剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/jm401312n
Dibrov, Sergey M; Parsons, Jerod; Carnevali, Maia; Zhou, Shu; Rynearson, Kevin D; Ding, Kejia; Garcia Sega, Emily; Brunn, Nicholas D; Boerneke, Mark A; Castaldi, Maria P; Hermann, Thomas
微生物学
肝炎
发表日期：2014
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Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.

可溶性β-分泌酶调节剂选择性地抑制42个氨基酸的淀粉样β肽变体的产生，并增强多种羧基截短的淀粉样β物种的产生

期刊:Biochemistry
影响因子:3
doi:10.1021/bi401537v
Wagner Steven L, Zhang Can, Cheng Soan, Nguyen Phuong, Zhang Xulun, Rynearson Kevin D, Wang Rong, Li Yueming, Sisodia Sangram S, Mobley William C, Tanzi Rudolph E
其它
发表日期：2014
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2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site

丙型肝炎病毒内部核糖体进入位点的2-氨基苯并恶唑配体

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2014.05.088
Rynearson, Kevin D; Charrette, Brian; Gabriel, Christopher; Moreno, Jesus; Boerneke, Mark A; Dibrov, Sergey M; Hermann, Thomas
微生物学
肝炎
发表日期：2014
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