日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial

BCMA靶向mRNA CAR T细胞疗法治疗重症肌无力:一项随机、双盲、安慰剂对照的2b期试验

Vu, Tuan; Durmus, Hacer; Rivner, Michael; Shroff, Sheetal; Ragole, Thomas; Myers, Bennett; Pasnoor, Mamatha; Small, George; Karam, Chafic; Vullaganti, Mithila; Peltier, Amanda; Sahagian, Gregory; Feinberg, Marc H; Slanksy, Adam; Barnett-Tapia, Carolina; Siddiqi, Zaeem; Gwathmey, Kelly; Badruddoja, Michael A; Kamboh, Hafsa; Ruggerie, Rachel N; Fedak, Renee R; Stewart, C Andrew; Kurtoglu, Metin; Kalayoglu, Murat; Singer, Michael; Jewell, Christopher M; Miljkovic, Milos D; Dimachkie, Mazen; Mozaffar, Tahseen; Howard, James F Jr

BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial.

BCMA 靶向 mRNA CAR-T 细胞疗法治疗重症肌无力:安慰剂对照 2b 期试验的探索性生物标志物分析。

Fedak Renee R, Ruggerie Rachel N, Shan Yufei, Curvino Elizabeth J, de Sousa Juliana F, Daniel Shaji, Ngo-Casi Minhtran, Kamboh Hafsa, Vu Tuan, Durmuş Hacer, Mozaffar Tahseen, Howard James F Jr, English Emily P, Benson Albina, Duvernay Matthew T, Singer Michael S, Kalayoglu Murat V, Brunn Carsten, Bodansky Aaron, Anderson Mark S, DeRisi Joseph L, Garcia Samantha T, Yu David J L, Zorn Kelsey C, Kurtoglu Metin, Miljković Miloš D, Stewart C Andrew, Jewell Christopher M

Integrase anchors viral RNA to the HIV-1 capsid interior

整合酶将病毒RNA锚定到HIV-1衣壳内部

Singer, Matthew R; Li, Zhen; Rey, Juan S; Hope, Joshua; Chenavier, Florian; Cook, Nicola J; Punch, Emma; Smith, Jamie; Zhou, Zhiyu; Maslen, Sarah; Masino, Laura; Nans, Andrea; Skehel, Mark; Taylor, Ian A; Zanetti, Giulia; Zhang, Peijun; Perilla, Juan R; Engelman, Alan N; Cherepanov, Peter

Atomically accurate de novo design of antibodies with RFdiffusion

利用射频扩散技术进行原子级精确的抗体从头设计

Bennett, Nathaniel R; Watson, Joseph L; Ragotte, Robert J; Borst, Andrew J; See, DéJenaé L; Weidle, Connor; Biswas, Riti; Yu, Yutong; Shrock, Ellen L; Ault, Russell; Leung, Philip J Y; Huang, Buwei; Goreshnik, Inna; Tam, John; Carr, Kenneth D; Singer, Benedikt; Criswell, Cameron; Wicky, Basile I M; Vafeados, Dionne; Garcia Sanchez, Mariana; Kim, Ho Min; Vázquez Torres, Susana; Chan, Sidney; Sun, Shirley M; Spear, Timothy T; Sun, Yi; O'Reilly, Keelan; Maris, John M; Sgourakis, Nikolaos G; Melnyk, Roman A; Liu, Chang C; Baker, David

Secretome translation shaped by lysosomes and lunapark-marked ER junctions.

溶酶体和lunapark标记的内质网连接处塑造了分泌组的翻译。

Choi Heejun, Liao Ya-Cheng, Yoon Young J, Grimm Jonathan, Wang Nan, Lavis Luke D, Singer Robert H, Lippincott-Schwartz Jennifer

Nanomaterial-Based Therapeutic Delivery: Integrating Redox Biology, Genetic Engineering, and Imaging-Guided Treatment

基于纳米材料的治疗递送:整合氧化还原生物学、基因工程和影像引导治疗

Plazyo, Olesya; Chopp, Laura B; Peela, Rishyanth; Young, Kelly; Zhang, Haihan; Bogle, Rachael; Hesson, Ashley; Langen, Elizabeth S; Bergin, Ingrid L; Syu, Li-Jyun; Erba, Jake; Kirma, Joseph; Dey, Poulami; Zhang, Lin; Sarkar, Mrinal K; Swindell, William R; Gallagher, Katherine A; Ward, Nicole L; Singer, Kanakadurga; Kahlenberg, J Michelle; Billi, Allison C; Dlugosz, Andrzej A; Ganesh, Santhi K; Tsoi, Lam C; Gudjonsson, Johann E; Ripp, Leonie; Kätzel, Dennis; Bartusik-Aebisher, Dorota; Justin Raj, Daniel Roshan; Aebisher, David

A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions

GOLGA8A基因的重复扩增是伴有泛素阳性包涵体的非典型额颞叶变性的主要风险因素。

De Coster, Wouter; Van den Broeck, Marleen; Baker, Matt; Ghayal, Nikhil B; Wynants, Sarah; Batzler, Anthony; Pottier, Cyril; Alidadiani, Sara; Küçükali, Fahri; Jenkins, Gregory D; Policarpo, Rafaela; van Blitterswijk, Marka; DeJesus-Hernandez, Mariely; Soto-Beasley, Alexandra I; Faura, Júlia; Coopman, Elise; Hutten, Saskia; Mol, Merel O; Wallon, David; Sieben, Anne; Finger, Elizabeth C; Murray, Melissa E; Forrest, Shelley L; Tartaglia, Maria C; Troakes, Claire; van Rooij, Jeroen G J; Nguyen, Aivi T; Reichard, R Ross; Woodman, Natalie L; Nana, Alissa L; Weintraub, Sandra; Gefen, Tamar; De Vil, Bart; Bodi, Istvan; Lopez, Oscar L; Boluda, Susana; Belliard, Serge; Lebert, Florence; Marguet, Florent; Mao, Qinwen; Mesulam, Marsel M; Boxer, Adam L; Vandenbulcke, Mathieu; Suh, EunRan; Schaeverbeke, Jolien; Lambert, Jean-Charles; Scholz, Sonja W; Dalgard, Clifton L; Traynor, Bryan J; Gibbs, Raphael J; Schellenberg, Gerard D; Dormann, Dorothee; Joris, Geert; De Pooter, Tim; De Rijk, Peter; D'Hert, Svenn; Van Dongen, Jasper; van der Zee, Julie; Strazisar, Mojca; Gearing, Marla; Kukar, Thomas; Flanagan, Margaret; Engelborghs, Sebastiaan; Ghetti, Bernardino; Newell, Kathy L; King, Andrew; Roeber, Sigrun; Rosen, Howard J; Spina, Salvatore; Cras, Patrick; Ertekin-Taner, Nilüfer; Wszolek, Zbigniew K; Uitti, Ryan J; Cheshire, William P; Singer, Wolfgang; Herms, Jochen; Josephs, Keith A; Whitwell, Jennifer L; Petersen, Ronald C; Pasquier, Florence; Nicolas, Gaël; Castellani, Rudolph; Glass, Jonathan; Miller, Bruce L; Kovacs, Gabor G; Rissman, Robert A; Hiniker, Annie; Deramecourt, Vincent; Ang, Lee-Cyn; Lee-Way, Jin; Van Deerlin, Vivianna M; Dugger, Brittany N; Thal, Dietmar R; Grinberg, Lea T; Cruchaga, Carlos; Arzberger, Thomas; Munoz, David G; Keith, Julia; Zinman, Lorne; Rogaeva, Ekaterina; Lee, Edward B; Haggarty, Stephen J; Ansorge, Olaf; Husain, Masud; Halliday, Glenda M; Al-Sarraj, Safa; Ross, Owen A; Sleegers, Kristel; Vandenberghe, Rik; Boeve, Bradley F; Graff-Radford, Neill R; Kofler, Julia; White, Charles L 3rd; Lashley, Tammaryn; Neumann, Manuela; Biernacka, Joanna M; Seeley, William W; Seelaar, Harro; van Swieten, John C; Rohrer, Jonathan D; Dickson, Dennis W; Mackenzie, Ian R A; Rademakers, Rosa

Unraveling CD8 lineage decisions reveals that functionally distinct CD8(+) T cells are selected by different MHC-I thymic peptides

揭示 CD8 谱系决定机制表明,功能不同的 CD8(+) T 细胞是由不同的 MHC-I 胸腺肽选择的。

Shinzawa, Miho; Ramos, Nicole; Bui, Khanh; Hajjar, William; Crossman, Assiatu; Chen, Xiongfong; Cam, Margaret; Takahama, Yousuke; Singer, Alfred

Engineered bacteria launch and control an oncolytic virus

基因工程改造的细菌启动并控制溶瘤病毒

Singer, Zakary S; Pabón, Jonathan; Huang, Hsinyen; Sun, William; Luo, Hongsheng; Grant, Kailyn Rhyah; Obi, Ijeoma; Coker, Courtney; Rice, Charles M; Danino, Tal

Mortality trends in sepsis… or how to kill two birds with one stone?

脓毒症死亡率趋势……或者说,如何一石二鸟?

Bauer, Michael; Tissières, Pierre; Singer, Mervyn