日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12C.

Divarasib (GDC-6036) 的发现和表征,一种强效的 KRAS G12C 共价抑制剂。

Endres Nicholas F, Do Steven, Mroue Rana, Terrett Jack A, Saabye Matt, Oh Angela, Hunsaker Thomas, Chan Emily, Tran John C, Nguyen Lan K, Lian Qihui, Ma Taylur P, Garner Thomas, Gerosa Luca, Beresini Maureen, Boudreau Aaron, Bronner Sarah M, Cyr Patrick, Ishisoko Noriko, Izrayelit Yevgeniy, Jiang Fan, Kellar Terry, La Hank, Labadie Sharada, Lardy Matthew, Liu Liling, Liu Wendy, Miller Sarah, Rudolph Joachim, Plise Emile, Sellers Benjamin D, Shao Cheng, Wang Weiru, Wang Yanguang, Wei Wentao, Wong Susan, Yu Christine, Yu Kebing, Yuen Po-Wai, Zang Richard, Zhang Chenghong, Zhou Yuhui, Zhu Xiaoyu, Quinn John G, Ye Xin, Kiefer James R, Mao Jialin, Evangelista Marie, Merchant Mark, Landry Matthew L, Malhotra Sushant, Purkey Hans E

Correction to "Combining Fundamental Kinetics and Standard Alkylation Assays to Prioritize Lead-like KRAS G12C Inhibitors"

对“结合基础动力学和标准烷基化分析来优先筛选先导化合物KRAS G12C抑制剂”一文的更正

Frommlet, Alexandra; Nguyen, Lan K; Saabye, Matt; Endres, Nicholas F; Mulvihill, Melinda M; Quinn, John G

Test-retest reliability of clinical measurements of lower extremity joint motion and alignment in the pediatric population

儿童人群下肢关节运动和排列临床测量的重测信度

Saabye, Thea; Colding-Rasmussen, Thomas; Balslev-Clausen, Andreas; Bødtker, Søren; Wong, Christian; Harsted, Steen

Combining Fundamental Kinetics and Standard Alkylation Assays to Prioritize Lead-Like KRAS G12C Inhibitors

结合基础动力学和标准烷基化分析,筛选具有先导化合物潜力的KRAS G12C抑制剂

Frommlet, Alexandra; Nguyen, Lan K; Saabye, Matt; Endres, Nicholas F; Mulvihill, Melinda M; Quinn, John G

Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals

选择性抑制 p38α MAPK-MK2 轴可抑制炎症信号,包括炎症小体启动信号

Chun Wang, Susan Hockerman, E Jon Jacobsen, Yael Alippe, Shaun R Selness, Heidi R Hope, Jeffrey L Hirsch, Stephen J Mnich, Matthew J Saabye, William F Hood, Sheri L Bonar, Yousef Abu-Amer, Ariela Haimovich, Hal M Hoffman, Joseph B Monahan, Gabriel Mbalaviele

Clinical evaluation of a matrix metalloproteinase-12 cleaved fragment of titin as a cardiovascular serological biomarker

肌联蛋白基质金属蛋白酶-12裂解片段作为心血管血清学标志物的临床评价

Vassiliadis, Efstathios; Rasmussen, Lars M; Byrjalsen, Inger; Larsen, Dorthe Vang; Chaturvedi, Rajiv; Hosbond, Susanne; Saabye, Lotte; Diederichsen, Axel C P; Genovese, Federica; Duffin, Kevin L; Zheng, Qinlong; Chen, Xiaoliang; Leeming, Diana J; Christiansen, Claus; Karsdal, Morten A

A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation

丝裂原活化蛋白激酶-活化蛋白激酶 2 的苯并噻吩抑制剂可抑制肿瘤坏死因子 α 的产生,并在急性和慢性炎症模型中具有口服抗炎功效

Robert J Mourey, Barry L Burnette, Sarah J Brustkern, J Scott Daniels, Jeffrey L Hirsch, William F Hood, Marvin J Meyers, Stephen J Mnich, Betsy S Pierce, Matthew J Saabye, John F Schindler, Sarah A South, Elizabeth G Webb, Jian Zhang, David R Anderson

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

JAK1/JAK3 抑制剂 CP-690,550 在大鼠佐剂诱发关节炎中介导的抗炎活性和中性粒细胞减少

Debra M Meyer, Michael I Jesson, Xiong Li, Mollisa M Elrick, Christie L Funckes-Shippy, James D Warner, Cindy J Gross, Martin E Dowty, Shashi K Ramaiah, Jeffrey L Hirsch, Matthew J Saabye, Jennifer L Barks, Nandini Kishore, Dale L Morris

Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation

新型 N-苯基吡啶酮 p38 丝裂原活化蛋白激酶抑制剂的抗炎特性:临床前至临床的转化

Heidi R Hope, Gary D Anderson, Barry L Burnette, Robert P Compton, Rajesh V Devraj, Jeffrey L Hirsch, Robert H Keith, Xiong Li, Gabriel Mbalaviele, Dean M Messing, Matthew J Saabye, John F Schindler, Shaun R Selness, Loreen I Stillwell, Elizabeth G Webb, Jian Zhang, Joseph B Monahan