日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Altered trafficking of Kv1-Kvβ2 leads to neuronal hyperexcitability and memory deficits in amyloid-β pathology.

Kv1-Kvβ2 转运异常导致淀粉样蛋白β病理中的神经元过度兴奋和记忆缺陷。

Cho Young-Sin, Kim Seo-Hyun, Ryu Shin-Hyeon, Chung Chaelin, Lee Nahyun, Kim Namhoon, Jeong Muhah, Kim Youngwon, Gwak Jimin, Choi Se-Young, Saido Takaomi, Jung Yong-Keun

C3 lowering in adult APP KI mice rescues synapses and spares cognitive decline

降低成年APP KI小鼠体内C3水平可挽救突触并延缓认知衰退

Singh, Brijendra; Batista, Andre F; Spooner, Emma T; Colletti, Brianna R; Saido, Takaomi C; Carroll, Michael C; Lemere, Cynthia A

Early Binding of Anti-Amyloid Antibodies to CAA Drives Complement Activation, Inflammation and ARIA in Mice.

抗淀粉样蛋白抗体与 CAA 的早期结合可驱动小鼠体内的补体激活、炎症和 ARIA。

Bathini Praveen, Schilling Stephan, Rahfeld Jens-Ulrich, Holtzman David M, Saido Takaomi C, Lemere Cynthia A

In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds

体内tau蛋白过度磷酸化与突触丢失和行为异常有关,即使不存在tau蛋白种子。

Naoto Watamura #,Martha S Foiani #,Sumi Bez,Mathieu Bourdenx,Alessia Santambrogio,Claire Frodsham,Elena Camporesi,Gunnar Brinkmalm,Henrik Zetterberg,Saisha Patel,Naoko Kamano,Mika Takahashi,Javier Rueda-Carrasco,Loukia Katsouri,Stephanie Fowler,Emir Turkes,Shoko Hashimoto,Hiroki Sasaguri,Takashi Saito,Afm Saiful Islam,Seico Benner,Toshihiro Endo,Katsuji Kobayashi,Chiho Ishida,Michele Vendruscolo,Masahito Yamada,Karen E Duff,Takaomi C Saido

Rod-shaped microglia represent a morphologically distinct subpopulation of disease-associated microglia

棒状小胶质细胞是疾病相关小胶质细胞中形态学上独特的亚群。

Matsuba, Yukio; Nagata, Kenichi; Kadota, Yosuke; Sahara, Naruhiko; Saido, Takaomi C; Hashimoto, Shoko

Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils

选择性激动 GPR34 可刺激小胶质细胞摄取和清除淀粉样β纤维

Etani, Hayato; Takatori, Sho; Wang, Wenbo; Omi, Jumpei; Amiya, Yusuke; Akahori, Aika; Watanabe, Hirotaka; Sonn, Iki; Okano, Hideyuki; Hara, Norikazu; Hasegawa, Mai; Miyashita, Akinori; Kikuchi, Masataka; Ikeuchi, Takeshi; Morishima, Maho; Saito, Yuko; Murayama, Shigeo; Saito, Takashi; Saido, Takaomi C; Takai, Toshiyuki; Ohwada, Tomohiko; Aoki, Junken; Tomita, Taisuke

Misclassification in memory modification in AppNL-G-F knock-in mouse model of Alzheimer's disease

AppNL-GF敲入小鼠阿尔茨海默病模型中记忆改变的错误分类

Mei-Lun Huang ,Yusuke Suzuki ,Hiroki Sasaguri ,Takashi Saito ,Takaomi C Saido ,Itaru Imayoshi

Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer's disease.

Aβ驱动的核孔复合体功能障碍会改变阿尔茨海默病小鼠模型中坏死性凋亡蛋白的激活

Bansal Vibhavari Aysha, Tan Jia Min, Soon Hui Rong, Zainolabidin Norliyana, Saido Takaomi, Ch'ng Toh Hean

Experimental evidence that readily diffusible forms of Aβ from Alzheimer's disease brain have seeding activity.

实验证据表明,阿尔茨海默病患者大脑中易扩散的 Aβ 形式具有播种活性

Song Simin, Liu Qianmin, Chen Ruixiang, Chen Ping, Tao Min, Li Siyao, Guo Liping, Zhu Xixi, Liu Yan, Liu Lu, Sasaguri Hiroki, Saito Takashi, Saido Takaomi C, Walsh Dominic M, Zhang Zhangjin, Hong Wei

Sex-related upregulation of bone morphogenetic protein signaling inhibits adult neurogenesis in APP(NL-G-F) alzheimer's disease model mice.

骨形态发生蛋白信号传导的性别相关上调抑制 APP(NL-GF) 阿尔茨海默病模型小鼠的成年神经发生。

Su Xingyu, Takayanagi Rina, Maeda Hiroki, Saido Takaomi C, Ohshima Toshio