日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease

小胶质细胞 INPP5D 限制阿尔茨海默病 PSAPP 小鼠模型中的斑块形成和神经胶质反应性

Emilie L Castranio, Philip Hasel, Jean-Vianney Haure-Mirande, Angie V Ramirez Jimenez, B Wade Hamilton, Rachel D Kim, Charles G Glabe, Minghui Wang, Bin Zhang, Sam Gandy, Shane A Liddelow, Michelle E Ehrlich

BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPTP301S mouse model of tauopathy

BCI-838 是一种口服 mGluR2/3 受体拮抗剂前药,可挽救 PS19 MAPTP301S 小鼠 tau 蛋白病模型中的学习行为缺陷

Georgina Perez-Garcia, Mesude Bicak, Jean-Vianney Haure-Mirande, Gissel M Perez, Alena Otero-Pagan, Miguel A Gama Sosa, Rita De Gasperi, Mary Sano, Carrolee Barlow, Fred H Gage, Benjamin Readhead, Michelle E Ehrlich, Sam Gandy, Gregory A Elder

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease

阿尔茨海默病中线粒体蛋白、APP和tau蛋白的琥珀酰化改变

Yun Yang ,Victor Tapias ,Diana Acosta ,Hui Xu ,Huanlian Chen ,Ruchika Bhawal ,Elizabeth T Anderson ,Elena Ivanova ,Hening Lin ,Botir T Sagdullaev ,Jianer Chen ,William L Klein ,Kirsten L Viola ,Sam Gandy ,Vahram Haroutunian ,M Flint Beal ,David Eliezer ,Sheng Zhang ,Gary E Gibson

Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces β-Amyloid Load in Males and Females

双特异性蛋白磷酸酶 4 (DUSP4) 过表达选择性地改善雌性 5xFAD 小鼠的学习行为,并降低雄性和雌性小鼠的 β-淀粉样蛋白负荷

Allen L Pan ,Mickael Audrain ,Emmy Sakakibara ,Rajeev Joshi ,Xiaodong Zhu ,Qian Wang ,Minghui Wang ,Noam D Beckmann ,Eric E Schadt ,Sam Gandy ,Bin Zhang ,Michelle E Ehrlich ,Stephen R Salton

World Trade Center dust induces nasal and neurological tissue injury while propagating reduced olfaction capabilities and increased anxiety behaviors

世贸中心灰尘会引发鼻腔和神经组织损伤,同时导致嗅觉能力下降和焦虑行为增加

Michelle Hernandez, Joshua Vaughan, Terry Gordon, Morton Lippmann, Sam Gandy, Lung-Chi Chen

Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease

利用多组学数据进行变革性网络建模,揭示阿尔茨海默病的详细回路、关键调控因子和潜在疗法

Minghui Wang ,Aiqun Li ,Michiko Sekiya ,Noam D Beckmann ,Xiuming Quan ,Nadine Schrode ,Michael B Fernando ,Alex Yu ,Li Zhu ,Jiqing Cao ,Liwei Lyu ,Emrin Horgusluoglu ,Qian Wang ,Lei Guo ,Yuan-Shuo Wang ,Ryan Neff ,Won-Min Song ,Erming Wang ,Qi Shen ,Xianxiao Zhou ,Chen Ming ,Seok-Man Ho ,Sezen Vatansever ,H Ümit Kaniskan ,Jian Jin ,Ming-Ming Zhou ,Kanae Ando ,Lap Ho ,Paul A Slesinger ,Zhenyu Yue ,Jun Zhu ,Pavel Katsel ,Sam Gandy ,Michelle E Ehrlich ,Valentina Fossati ,Scott Noggle ,Dongming Cai ,Vahram Haroutunian ,Koichi M Iijima ,Eric Schadt ,Kristen J Brennand ,Bin Zhang

Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast

侧向性和区域特异性 tau 磷酸化与暴露于重复低水平爆炸的大鼠的 PTSD 相关行为特征相关

Georgina Perez Garcia #, Rita De Gasperi #, Miguel A Gama Sosa, Gissel M Perez, Alena Otero-Pagan, Dylan Pryor, Rania Abutarboush, Usmah Kawoos, Patrick R Hof, Dara L Dickstein, David G Cook, Sam Gandy, Stephen T Ahlers, Gregory A Elder

Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation

低水平爆炸暴露诱发慢性血管重塑、血管周围星形胶质细胞变性和血管相关神经炎症

Miguel A Gama Sosa, Rita De Gasperi, Dylan Pryor, Georgina S Perez Garcia, Gissel M Perez, Rania Abutarboush, Usmah Kawoos, Seth Hogg, Benjamin Ache, William G Janssen, Allison Sowa, Timothy Tetreault, David G Cook, Susan J Tappan, Sam Gandy, Patrick R Hof, Stephen T Ahlers, Gregory A Elder

Repetitive Low-Level Blast Exposure Improves Behavioral Deficits and Chronically Lowers Aβ42 in an Alzheimer Disease Transgenic Mouse Model

重复低强度冲击波暴露可改善阿尔茨海默病转基因小鼠模型的行为缺陷并长期降低 Aβ42

Georgina Perez Garcia, Rita De Gasperi, Anna E Tschiffely, Miguel A Gama Sosa, Rania Abutarboush, Usmah Kawoos, Jonathan K Statz, Stephanie Ciarlone, Eileen Reed, Theepica Jeyarajah, Gissel M Perez, Alena Otero-Pagan, Dylan Pryor, Patrick R Hof, David G Cook, Sam Gandy, Gregory A Elder, Stephen T Ah

VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice

VGF 衍生肽 TLQP-21 通过 C3aR1 信号通路调节小胶质细胞功能并减少 5xFAD 小鼠的神经病理学

Farida El Gaamouch, Mickael Audrain, Wei-Jye Lin, Noam Beckmann, Cheng Jiang, Siddharth Hariharan, Peter S Heeger, Eric E Schadt, Sam Gandy, Michelle E Ehrlich, Stephen R Salton