日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A community-led initiative to de-risk and advance Parkinson's disease therapeutic targets

一项由社区主导的倡议,旨在降低帕金森病治疗靶点的风险并推进其发展

Vaiana, Alexandra; Behr, Jonathan; Birol, Ryan; Blauwendraat, Cornelis; Casey, Bradford; Chowdhury, Kushan; Citron, Martin; Crapser, Joshua; Dardov, Victoria; Ducotterd, Fiona; Dumanis, Sonya; Dunlop, John; Durborow, Michelle; Fiske, Brian; Golden, Jessica; Hannestad, Jonas; Hung, Wendy; Kemp, Jennifer; Kleiman, Robin; Knight, Adam; Koemeter-Cox, Andrew; Leuchter, Bruce; Logsdon, Bejamin A; Marreiros, Rita; Miller, Julie E; Mitchell, Amanda; Mukherjee, Pooja; Navarro, Grace; Nelson, Matthew R; Nikolich, Karoly; Otis, Tom; Polinski, Nicole; Rastegar-Pouyani, Shima; Reith, Alastair D; Riley, Ekemini; Rubin, Lee; Ryten, Mina; Sadick, Jessica; Schwabe, Tina; Sherer, Todd; Silvergleid, Sarah; Singleton, Andrew; St Clair, Lara; Stoehr, Jan; Stone, David J; Sullivan, Julianna; Tanenbaum, Nicole; Tinelli, Elisa; Trimble, Kate; Wang, Yifei; Weninger, Stacie; Wiggenhauser, Nicolás; Wood, Stephen; Schoepp, Darryle; Buggia-Prevot, Virginie; Padmanabhan, Shalini; Skibinski, Gaia

Development of AL101 (GSK4527226), a progranulin-elevating monoclonal antibody, as a potential treatment for Alzheimer's disease.

AL101 (GSK4527226) 是一种可提高前粒蛋白水平的单克隆抗体,其开发有望成为治疗阿尔茨海默病的一种潜在疗法

Budda Balasubrahmanyam, Mitra Ananya, Park Lovingly, Long Hua, Kurnellas Michael, Bien-Ly Nga, Estacio William, Burgess Brady, Chao Grace, Schwabe Tina, Paul Robert, Kenkare-Mitra Sara, Rosenthal Arnon

Functional and structural characterization of interactions between opposite subunits in HCN pacemaker channels

HCN起搏通道中相反亚基间相互作用的功能和结构表征

Kondapuram, Mahesh; Frieg, Benedikt; Yüksel, Sezin; Schwabe, Tina; Sattler, Christian; Lelle, Marco; Schweinitz, Andrea; Schmauder, Ralf; Benndorf, Klaus; Gohlke, Holger; Kusch, Jana

Uncoupling of Voltage- and Ligand-Induced Activation in HCN2 Channels by Glycine Inserts

甘氨酸插入导致HCN2通道中电压和配体诱导激活的解耦联

Yüksel, Sezin; Bonus, Michele; Schwabe, Tina; Pfleger, Christopher; Zimmer, Thomas; Enke, Uta; Saß, Inga; Gohlke, Holger; Benndorf, Klaus; Kusch, Jana

Allosteric signaling in C-linker and cyclic nucleotide-binding domain of HCN2 channels

HCN2通道C连接区和环核苷酸结合域的变构信号传导

Pfleger, Christopher; Kusch, Jana; Kondapuram, Mahesh; Schwabe, Tina; Sattler, Christian; Benndorf, Klaus; Gohlke, Holger

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model

抗人TREM2抗体可诱导小胶质细胞增殖并减轻阿尔茨海默病模型中的病理损伤。

Wang, Shoutang; Mustafa, Meer; Yuede, Carla M; Salazar, Santiago Viveros; Kong, Philip; Long, Hua; Ward, Michael; Siddiqui, Omer; Paul, Robert; Gilfillan, Susan; Ibrahim, Adiljan; Rhinn, Hervé; Tassi, Ilaria; Rosenthal, Arnon; Schwabe, Tina; Colonna, Marco

N(6)-modified cAMP derivatives that activate protein kinase A also act as full agonists of murine HCN2 channels

激活蛋白激酶A的N(6)修饰的cAMP衍生物也可作为小鼠HCN2通道的完全激动剂。

Leypold, Tim; Bonus, Michele; Spiegelhalter, Felix; Schwede, Frank; Schwabe, Tina; Gohlke, Holger; Kusch, Jana

Dynamic analysis of the mesenchymal-epithelial transition of blood-brain barrier forming glia in Drosophila.

果蝇血脑屏障形成胶质细胞间质-上皮转化的动态分析

Schwabe Tina, Li Xiaoling, Gaul Ulrike

Differential adhesion determines the organization of synaptic fascicles in the Drosophila visual system

差异性粘附决定了果蝇视觉系统中突触束的组织结构。

Schwabe, Tina; Borycz, Jolanta A; Meinertzhagen, Ian A; Clandinin, Thomas R

More than just glue: the diverse roles of cell adhesion molecules in the Drosophila nervous system

不仅仅是粘合剂:细胞粘附分子在果蝇神经系统中的多种作用

Schwabe, Tina; Gontang, Allison C; Clandinin, Thomas R