日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity

吞噬细胞作为斑块催化剂：人巨噬细胞产生具有交叉播散活性的、可播散斑块的Aβ42原纤维

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2516774123
Konstantoulea, Katerina; Ramakers, Meine; Borrie, Sarah C; T'Syen, Dries; Moechars, Daan; Sliwinska, Malgorzata A; Pradhan, Brajabandhu; Albertini, Giulia; Baligács, Nóra; Tsaka, Grigoria; Houben, Bert; Fiers, Mark; Gallardo, Rodrigo; Dewilde, Maarten; Thal, Dietmar Rudolf; Willem, Michael; Neher, Jonas J; De Strooper, Bart; Rousseau, Frederic; Schymkowitz, Joost
Human
免疫/内分泌
细胞生物学
巨噬细胞
巨噬细胞
发表日期：2026
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Conformation-specific monoclonal antibodies reveal early Tau structural intermediates in Alzheimer's disease

构象特异性单克隆抗体揭示阿尔茨海默病早期Tau蛋白结构中间体

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2026.111221
Tsaka, Grigoria; Pagès, Aida Montserrat; De Sousa, Cristiano Brás; Lammertyn, Jeroen; Walkiewicz, Grzegorz; Gomes, Luis Aragão; Imbrechts, Maya; Tops, Sophie; Kolla, Rajasekhar; Muwonge, Kevin; Vandenberghe, Rik; Vanhoorelbeke, Karen; von Arnim, Christine A F; Geukens, Nick; Rousseau, Frederic; Schymkowitz, Joost; Spasic, Dragana; Thal, Dietmar Rudolf; Thomas, Debby; Winderickx, Joris
单克隆抗体
阿尔茨海默症
发表日期：2026
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Composition and liquid-to-solid maturation of protein aggregates contribute to bacterial dormancy development and recovery

蛋白质聚集体的组成和液固转变过程有助于细菌休眠的发生和恢复。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-56387-8
Bollen, Celien; Louwagie, Sofie; Deroover, Femke; Duverger, Wouter; Khodaparast, Ladan; Khodaparast, Laleh; Hofkens, Dieter; Schymkowitz, Joost; Rousseau, Frederic; Dewachter, Liselot; Michiels, Jan
微生物学
发表日期：2025
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Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation

能量分析揭示了淀粉样蛋白原纤维成熟的热力学原理

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-65035-0
Duran-Romaña, Ramon; Schymkowitz, Joost; Rousseau, Frederic; Louros, Nikolaos
发表日期：2025
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Co-translational protein aggregation and ribosome stalling as a broad-spectrum antibacterial mechanism

共翻译蛋白质聚集和核糖体停滞作为广谱抗菌机制

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-025-56873-z
Laleh Khodaparast #, Ladan Khodaparast #, Ramon Duran-Romaña, Guiqin Wu, Bert Houben, Wouter Duverger, Matthias De Vleeschouwer, Katerina Konstantoulea, Fleur Nysen, Thomas Schalck, Daniel J Curwen, Lisandra L Martin, Sebastien Carpentier, Bernard Scorneaux, Jan Michiels, Joost Schymkowitz, Frederic
发表日期：2025
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Native Fold Delay and its implications for co-translational chaperone binding and protein aggregation

天然折叠延迟及其对共翻译分子伴侣结合和蛋白质聚集的影响

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-025-57033-z
Ramon Duran-Romaña # ，Bert Houben # ，Paula Fernández Migens ，Ying Zhang ，Frederic Rousseau ，Joost Schymkowitz
发表日期：2025
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A versatile platform for combinatorial antibody library cloning and NGS-based quality control with high accuracy

一个用于组合抗体库克隆和基于NGS的质量控制的多功能平台，具有高精度

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf1001
Zhang, Zhongyao; D'Hondt, Simon; Van der Kant, Rob; Hermans, Guy; Geukens, Nick; Pinheiro, Vitor Bernardes; Schymkowitz, Joost; Rousseau, Frederic; Dewilde, Maarten
发表日期：2025
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Development and evaluation of Hsp90-targeting nanobodies for visualisation of extracellular Hsp90 in tumours using PET imaging

开发和评估针对 Hsp90 的纳米抗体，以使用 PET 成像可视化肿瘤中的细胞外 Hsp90

期刊:EJNMMI Radiopharmacy and Chemistry
影响因子:4.4
doi:10.1186/s41181-025-00331-0
Valeria Narykina, Janke Kleynhans, Christopher Cawthorne, Joost Schymkowitz, Frederic Rousseau, Guy Bormans
肿瘤
肿瘤细胞
发表日期：2025
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Structural commonalities determined by physicochemical principles in the complex polymorphism of the amyloid state of proteins

蛋白质淀粉样蛋白状态复杂多态性中由物理化学原理决定的结构共性

期刊:Biochemical Journal
影响因子:4.3
doi:10.1042/BCJ20240602
Errico, Silvia; Fani, Giulia; Ventura, Salvador; Schymkowitz, Joost; Rousseau, Frederic; Trovato, Antonio; Vendruscolo, Michele; Bemporad, Francesco; Chiti, Fabrizio
发表日期：2025
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Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics with enhanced specificity and improved production capacity.

定向破坏 IL2 聚集和受体结合位点，可产生具有更高特异性和更强生产能力的定制生物制剂

期刊:Computational and Structural Biotechnology Journal
影响因子:4.1
doi:10.1016/j.csbj.2025.03.002
Dashwood Amy, Makuyana Ntombizodwa, van der Kant Rob, Ghodsinia Arman, Hernandez Alvaro R, Lienart Stephanie, Burton Oliver, Dooley James, Ali Magda, Kouser Lubna, Naranjo Francisco, Holt Matthew G, Rousseau Frederic, Schymkowitz Joost, Liston Adrian
其它
发表日期：2025
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