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The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship

临床表型与已知AD/FTD遗传风险位点的关联及其相互关系

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0241552

Li, Qingqin S; Tian, Chao; Hinds, David; Seabrook, Guy R

发表日期：2020

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Aiding the discovery of new treatments for dementia by uncovering unknown benefits of existing medications

通过发掘现有药物的未知益处，帮助发现治疗痴呆症的新方法

期刊:Alzheimer's and Dementia: Translational Research and Clinical Interventions

影响因子:6.8

doi:10.1016/j.trci.2019.07.012

Kern, David M; Cepeda, M Soledad; Lovestone, Simon; Seabrook, Guy R

发表日期：2019

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Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists

发现3-取代氨基环戊烷类化合物是高效且口服生物利用度高的NR2B亚型选择性NMDA拮抗剂

期刊:ACS Chemical Neuroscience

影响因子:3.9

doi:10.1021/cn200013d

Layton, Mark E; Kelly, Michael J 3rd; Rodzinak, Kevin J; Sanderson, Philip E; Young, Steven D; Bednar, Rodney A; Dilella, Anthony G; McDonald, Terrence P; Wang, Hao; Mosser, Scott D; Fay, John F; Cunningham, Michael E; Reiss, Duane R; Fandozzi, Christine; Trainor, Nicole; Liang, Annie; Lis, Edward V; Seabrook, Guy R; Urban, Mark O; Yergey, James; Koblan, Kenneth S

发表日期：2011

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A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1

一项关于过表达淀粉样前体蛋白和早老素-1突变体的转基因小鼠长期增强作用的研究

期刊:Molecular Brain

影响因子:2.9

doi:10.1186/1756-6606-3-21

Fitzjohn, Stephen M; Kuenzi, Frederick; Morton, Robin A; Rosahl, Thomas W; Lewis, Huw; Smith, David; Seabrook, Guy R; Collingridge, Graham L

发表日期：2010

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The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells.

家族性偏瘫性偏头痛突变 R192Q 降低了 G 蛋白介导的 P/Q 型 (Ca(V)2.1) 钙通道在人类胚胎肾细胞中表达的抑制作用

期刊:Journal of Physiology-London

影响因子:4.4

doi:10.1113/jphysiol.2002.026716

Melliti Karim, Grabner Manfred, Seabrook Guy R

Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor

缺乏GABAA受体α5亚基的小鼠表现出学习和记忆增强以及GABA能突触传递改变。

期刊:Journal of Neuroscience

影响因子:4

doi:10.1523/JNEUROSCI.22-13-05572.2002

Collinson, Neil; Kuenzi, Frederick M; Jarolimek, Wolfgang; Maubach, Karen A; Cothliff, Rosa; Sur, Cyrille; Smith, Alison; Otu, Franklin M; Howell, Owain; Atack, John R; McKernan, Ruth M; Seabrook, Guy R; Dawson, Gerry R; Whiting, Paul J; Rosahl, Thomas W

On the horizon-the value and promise of the global pipeline of Alzheimer's disease therapeutics

展望未来——全球阿尔茨海默病治疗药物研发管线的价值和前景

The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship

临床表型与已知AD/FTD遗传风险位点的关联及其相互关系

Aiding the discovery of new treatments for dementia by uncovering unknown benefits of existing medications

通过发掘现有药物的未知益处，帮助发现治疗痴呆症的新方法

Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists

发现3-取代氨基环戊烷类化合物是高效且口服生物利用度高的NR2B亚型选择性NMDA拮抗剂

A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1

一项关于过表达淀粉样前体蛋白和早老素-1突变体的转基因小鼠长期增强作用的研究

The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells.

家族性偏瘫性偏头痛突变 R192Q 降低了 G 蛋白介导的 P/Q 型 (Ca(V)2.1) 钙通道在人类胚胎肾细胞中表达的抑制作用

Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor

缺乏GABAA受体α5亚基的小鼠表现出学习和记忆增强以及GABA能突触传递改变。