日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular mechanisms limiting the AAV gene therapy treatment window in mouse models of blue cone monochromacy

限制蓝锥单色视小鼠模型中AAV基因治疗窗口的分子机制

Brothers, Brooke A; Sechrest, Emily R; Ma, Li; Ashcraft, Madyson E; Guan, Tongju; Barbera, Robert J; Shaw, Lee M; Chen, Becky; Baehr, Wolfgang; Hu, Gangqing; Stoilov, Peter; Deng, Wen-Tao

P23H rhodopsin accumulation causes transient disruptions to synaptic protein levels in rod photoreceptors in a model of retinitis pigmentosa.

在视网膜色素变性模型中,P23H 视紫红质的积累会导致视杆感光细胞突触蛋白水平的短暂紊乱

Thompson Samantha L, Crowder Sophie M, Hekmatara Maryam, Sechrest Emily R, Deng Wen-Tao, Robichaux Michael A

Structural and functional rescue of cones carrying the most common cone opsin C203R missense mutation

针对携带最常见视锥细胞视蛋白C203R错义突变的视锥细胞进行结构和功能恢复

Sechrest, Emily R; Ma, Xiaojie; Cahill, Marion E; Barbera, Robert J; Wang, Yixiao; Deng, Wen-Tao

Expression of red/green-cone opsin mutants K82E, P187S, M273K result in unique pathobiological perturbations to cone structure and function.

红/绿锥视蛋白突变体 K82E、P187S、M273K 的表达导致视锥细胞结构和功能出现独特的病理生物学扰动

Sechrest Emily R, Barbera Robert J, Ma Xiaojie, Dyka Frank, Ahn Junyeop, Brothers Brooke A, Cahill Marion E, Hall Isaac, Baehr Wolfgang, Deng Wen-Tao

Therapeutic potential of archaeal unfoldase PANet and the gateless T20S proteasome in P23H rhodopsin retinitis pigmentosa mice

古菌解折叠酶PANet和无门控T20S蛋白酶体在P23H视紫红质视网膜色素变性小鼠中的治疗潜力

Celine Brooks ,Douglas Kolson ,Emily Sechrest ,Janelle Chuah ,Jane Schupp ,Neil Billington ,Wen-Tao Deng ,David Smith ,Maxim Sokolov

P23H rhodopsin aggregation in the ER causes synaptic protein imbalance in rod photoreceptors

内质网中 P23H 视紫红质聚集导致杆状感光细胞突触蛋白失衡

Samantha L Thompson, Sophie M Crowder, Maryam Hekmatara, Emily R Sechrest, Wen-Tao Deng, Michael A Robichaux

Blue cone monochromacy and gene therapy

蓝锥单色视和基因治疗

Sechrest, Emily R; Chmelik, Kathryn; Tan, Wendy D; Deng, Wen-Tao

A Modified Acyl-RAC Method of Isolating Retinal Palmitoyl Proteome for Subsequent Detection through LC-MS/MS

一种改进的 Acyl-RAC 方法分离视网膜棕榈酰蛋白质组以便通过 LC-MS/MS 进行后续检测

Sree I Motipally, Boyden Myers, Emily R Sechrest, David Sokolov, Joseph Murphy, Saravanan Kolandaivelu

Harnessing island-ocean connections to maximize marine benefits of island conservation

利用岛屿与海洋的联系,最大限度地发挥岛屿保护对海洋的益处

Sandin, Stuart A; Becker, Penny A; Becker, Ceiba; Brown, Kate; Erazo, Natalia G; Figuerola, Cielo; Fisher, Robert N; Friedlander, Alan M; Fukami, Tadashi; Graham, Nicholas A J; Gruner, Daniel S; Holmes, Nick D; Holthuijzen, Wieteke A; Jones, Holly P; Rios, Mariela; Samaniego, Araceli; Sechrest, Wes; Semmens, Brice X; Thornton, Hazel E; Vega Thurber, Rebecca; Wails, Christy N; Wolf, Coral A; Zgliczynski, Brian J

Gene Therapy in Opn1mw-/-/Opn1sw-/- Mice and Implications for Blue Cone Monochromacy Patients with Deletion Mutations

Opn1mw-/-/Opn1sw-/- 小鼠的基因治疗及其对蓝锥单色视觉缺失突变患者的影响

Xiajie Ma, Emily R Sechrest, Diego Fajardo, Ping Zhu, Frank Dyka, Yixiao Wang, Ekaterina Lobanova, Shannon E Boye, Wolfgang Baehr, Wen-Tao Deng