日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Oxidized MIF is an Alzheimer's disease drug target relaying external risk factors to tau pathology

氧化型MIF是阿尔茨海默病药物靶点,它将外部风险因素传递给tau蛋白病理。

Andreas Müller-Schiffmann,Felix Torres,Anatoliy Kitaygorodskyy,Anand Ramani,Argyro Alatza,Sarah K Tschirner,Julien Orts,Arthur Haltrich,Ingrid Prikulis,Shaofeng Yu,Debendranath Dey,Suguna Mallesh,Dharma Prasad,Dennis Solas,Verian Bader,Annemieke Rozemuller,Selina Wray,Jay Gopalakrishnan,Roland Riek,Vishwanath R Lingappa,Carsten Korth

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis

PSEN1基因突变通过破坏调控性膜内蛋白水解,使家族性阿尔茨海默病星形胶质细胞模型中的炎症易于发生。

Oliver J Ziff ,Gustavo Morrone Parfitt ,Sarah Jolly ,Jackie M Casey ,Lucy Granat ,Satinder Samra ,Núria Setó-Salvia ,Argyro Alatza ,Leela Phadke ,Benjamin Galet ,Philippe Ravassard ,Marie-Claude Potier ,John Hardy ,Dervis A Salih ,Paul Whiting ,Fiona Ducotterd ,Rickie Patani ,Selina Wray # ,Charles Arber #

Somatic and Stem Cell Bank to Study the Contribution of African Ancestry to Dementia: African iPSC Initiative

体细胞和干细胞库研究非洲血统对痴呆症的影响:非洲 iPSC 计划

Mahmoud B Maina, Murtala B Isah, Jacob A Marsh, Zaid Muhammad, Larema Babazau, Abdulrahman Alkhamis Idris, Ekaterina Aladyeva, Nadia Miller, Emma Starr, Katherine J Miller, Scott Lee, Miguel Minaya, Selina Wray, Oscar Harari, Baba W Goni, Louise C Serpell, Celeste M Karch

The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestations

早老素1基因P436S突变会导致家族性阿尔茨海默病,伴有Aβ43升高和非典型临床表现。

Charles Arber ,Christopher R S Belder ,Filip Tomczuk ,Rebecca Gabriele ,Yazead Buhidma ,Clíona Farrell ,Antoinette O'Connor ,Helen Rice ,Tammaryn Lashley ,Nick C Fox ,Natalie S Ryan ,Selina Wray

The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1

GBA1 的注释被其蛋白质编码假基因 GBAP1 所掩盖

Emil K Gustavsson, Siddharth Sethi, Yujing Gao, Jonathan W Brenton, Sonia García-Ruiz, David Zhang, Raquel Garza, Regina H Reynolds, James R Evans, Zhongbo Chen, Melissa Grant-Peters, Hannah Macpherson, Kylie Montgomery, Rhys Dore, Anna I Wernick, Charles Arber, Selina Wray, Sonia Gandhi, Julian Ess

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease

选择性抑制少突胶质细胞来源的β-淀粉样蛋白可挽救阿尔茨海默病中的神经元功能障碍

Rikesh M Rajani ,Robert Ellingford ,Mariam Hellmuth ,Samuel S Harris ,Orjona S Taso ,David Graykowski ,Francesca Kar Wey Lam ,Charles Arber ,Emre Fertan ,John S H Danial ,Matthew Swire ,Marcus Lloyd ,Tatiana A Giovannucci ,Mathieu Bourdenx ,David Klenerman ,Robert Vassar ,Selina Wray ,Carlo Sala Frigerio ,Marc Aurel Busche

A reference human induced pluripotent stem cell line for large-scale collaborative studies

用于大规模合作研究的参考人诱导多能干细胞系

Caroline B Pantazis ,Andrian Yang ,Erika Lara ,Justin A McDonough ,Cornelis Blauwendraat ,Lirong Peng ,Hideyuki Oguro ,Jitendra Kanaujiya ,Jizhong Zou ,David Sebesta ,Gretchen Pratt ,Erin Cross ,Jeffrey Blockwick ,Philip Buxton ,Lauren Kinner-Bibeau ,Constance Medura ,Christopher Tompkins ,Stephen Hughes ,Marianita Santiana ,Faraz Faghri ,Mike A Nalls ,Daniel Vitale ,Shannon Ballard ,Yue A Qi ,Daniel M Ramos ,Kailyn M Anderson ,Julia Stadler ,Priyanka Narayan ,Jason Papademetriou ,Luke Reilly ,Matthew P Nelson ,Sanya Aggarwal ,Leah U Rosen ,Peter Kirwan ,Venkat Pisupati ,Steven L Coon ,Sonja W Scholz ,Theresa Priebe ,Miriam Öttl ,Jian Dong ,Marieke Meijer ,Lara J M Janssen ,Vanessa S Lourenco ,Rik van der Kant ,Dennis Crusius ,Dominik Paquet ,Ana-Caroline Raulin ,Guojun Bu ,Aaron Held ,Brian J Wainger ,Rebecca M C Gabriele ,Jackie M Casey ,Selina Wray ,Dad Abu-Bonsrah ,Clare L Parish ,Melinda S Beccari ,Don W Cleveland ,Emmy Li ,Indigo V L Rose ,Martin Kampmann ,Carles Calatayud Aristoy ,Patrik Verstreken ,Laurin Heinrich ,Max Y Chen ,Birgitt Schüle ,Dan Dou ,Erika L F Holzbaur ,Maria Clara Zanellati ,Richa Basundra ,Mohanish Deshmukh ,Sarah Cohen ,Richa Khanna ,Malavika Raman ,Zachary S Nevin ,Madeline Matia ,Jonas Van Lent ,Vincent Timmerman ,Bruce R Conklin ,Katherine Johnson Chase ,Ke Zhang ,Salome Funes ,Daryl A Bosco ,Lena Erlebach ,Marc Welzer ,Deborah Kronenberg-Versteeg ,Guochang Lyu ,Ernest Arenas ,Elena Coccia ,Lily Sarrafha ,Tim Ahfeldt ,John C Marioni ,William C Skarnes ,Mark R Cookson ,Michael E Ward ,Florian T Merkle

Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia

C9orf72 相关肌萎缩侧索硬化症和额颞叶痴呆症中内质网线粒体连接和信号传导中断

Patricia Gomez-Suaga, Gábor M Mórotz, Andrea Markovinovic, Sandra M Martín-Guerrero, Elisavet Preza, Natalia Arias, Keith Mayl, Afra Aabdien, Vesela Gesheva, Agnes Nishimura, Ambra Annibali, Younbok Lee, Jacqueline C Mitchell, Selina Wray, Christopher Shaw, Wendy Noble, Christopher C J Miller

The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissue

PSEN1 E280G突变导致诱导多能干细胞神经元中β-淀粉样蛋白43的产生增加,并在脑组织中沉积。

Nanet Willumsen ,Charles Arber ,Christopher Lovejoy ,Jamie Toombs ,Argyro Alatza ,Philip S J Weston ,Lucia Chávez-Gutiérrez ,John Hardy ,Henrik Zetterberg ,Nick C Fox ,Natalie S Ryan ,Tammaryn Lashley ,Selina Wray

MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration

MIR-NATs抑制MAPT翻译并帮助维持神经退行性疾病中的蛋白质稳态

Roberto Simone ,Faiza Javad ,Warren Emmett ,Oscar G Wilkins ,Filipa Lourenço Almeida ,Natalia Barahona-Torres ,Justyna Zareba-Paslawska ,Mazdak Ehteramyan ,Paola Zuccotti ,Angelika Modelska ,Kavitha Siva ,Gurvir S Virdi ,Jamie S Mitchell ,Jasmine Harley ,Victoria A Kay ,Geshanthi Hondhamuni ,Daniah Trabzuni ,Mina Ryten ,Selina Wray ,Elisavet Preza ,Demis A Kia ,Alan Pittman ,Raffaele Ferrari ,Claudia Manzoni ,Andrew Lees ,John A Hardy ,Michela A Denti ,Alessandro Quattrone ,Rickie Patani ,Per Svenningsson ,Thomas T Warner ,Vincent Plagnol ,Jernej Ule ,Rohan de Silva