日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dilated cardiomyopathy variant R14del increases phospholamban pentamer stability, blunting dynamic regulation of calcium

扩张型心肌病变体 R14del 可增加磷脂五聚体的稳定性,削弱钙的动态调节

Sean R Cleary, Allen C T Teng, Audrey Deyawe Kongmeneck, Xuan Fang, Taylor A Phillips, Ellen E Cho, Rhys A Smith, Patryk Karkut, Catherine A Makarewich, Peter M Kekenes-Huskey, Anthony O Gramolini, Seth L Robia

Pathological mutations in the phospholamban cytoplasmic region affect its topology and dynamics modulating the extent of SERCA inhibition

磷蛋白胞质区的病理性突变会影响其拓扑结构和动力学,从而调节SERCA抑制的程度。

Daniel K Weber ,U Venkateswara Reddy ,Seth L Robia ,Gianluigi Veglia

Mechanisms for cardiac calcium pump activation by its substrate and a synthetic allosteric modulator using fluorescence lifetime imaging

使用荧光寿命成像研究心脏钙泵由其底物和合成变构调节剂激活的机制

Jaroslava Šeflová, Carlos Cruz-Cortés, Guadalupe Guerrero-Serna, Seth L Robia, L Michel Espinoza-Fonseca

Inhibitory and stimulatory micropeptides preferentially bind to different conformations of the cardiac calcium pump

抑制和刺激性微肽优先与心脏钙泵的不同构象结合

Sean R Cleary, Xuan Fang, Ellen E Cho, Marsha P Pribadi, Jaroslava Seflova, Jordan R Beach, Peter M Kekenes-Huskey, Seth L Robia

Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA

矮开放阅读框(DWORF)是肌浆网钙泵SERCA的直接激活剂

M'Lynn E Fisher, Elisa Bovo #, Rodrigo Aguayo-Ortiz #, Ellen E Cho, Marsha P Pribadi, Michael P Dalton, Nishadh Rathod, M Joanne Lemieux, L Michel Espinoza-Fonseca, Seth L Robia, Aleksey V Zima, Howard S Young

Presenilin 1 is a direct regulator of the cardiac sarco/endoplasmic reticulum calcium pump

早老素 1 是心肌/内质网钙泵的直接调节剂

Elisa Bovo, Roman Nikolaienko, Daniel Kahn, Ellen Cho, Seth L Robia, Aleksey V Zima

Intrinsically disordered HAX-1 regulates Ca2+ cycling by interacting with lipid membranes and the phospholamban cytoplasmic region

内在无序的 HAX-1 通过与脂质膜和磷蛋白胞质区域相互作用来调节 Ca2+ 循环

Erik K Larsen, Daniel K Weber, Songlin Wang, Tata Gopinath, Daniel J Blackwell, Michael P Dalton, Seth L Robia, Jiali Gao, Gianluigi Veglia

Newly Discovered Micropeptide Regulators of SERCA Form Oligomers but Bind to the Pump as Monomers

新发现的 SERCA 微肽调节剂形成低聚物但以单体形式与泵结合

Deo R Singh, Michael P Dalton, Ellen E Cho, Marsha P Pribadi, Taylor J Zak, Jaroslava Šeflová, Catherine A Makarewich, Eric N Olson, Seth L Robia

Novel approach for quantification of endoplasmic reticulum Ca2+ transport

量化内质网 Ca2+ 转运的新方法

Elisa Bovo, Roman Nikolaienko, Siddharth Bhayani, Daniel Kahn, Quan Cao, Jody L Martin, Ivana Y Kuo, Seth L Robia, Aleksey V Zima

The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy

DWORF微肽增强扩张型心肌病小鼠模型的收缩力并预防心力衰竭

Catherine A Makarewich, Amir Z Munir, Gabriele G Schiattarella, Svetlana Bezprozvannaya, Olga N Raguimova, Ellen E Cho, Alexander H Vidal, Seth L Robia, Rhonda Bassel-Duby, Eric N Olson