日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Functional inactivation of MDR3 caused by a homozygous ABCB4 missense variant leading to liver failure

由ABCB4纯合错义变异引起的MDR3功能失活导致肝功能衰竭

Heinrich, Sophia; Behrendt, Annika; Sgodda, Malte; Gohlke, Holger; Auber, Bernd; Stalke, Amelie; Hartleben, Björn; Wedemeyer, Heiner; Cantz, Tobias; Taubert, Richard

iPSC-based hepatic organoids reveal a heterozygous MYO5B variant as driver of intrahepatic cholestasis

基于iPSC的肝脏类器官揭示了杂合MYO5B变异是肝内胆汁淤积的驱动因素

Sgodda, Malte; Gebel, Evelyn; Dignas, Lennart; Alfken, Susanne; Eggenschwiler, Reto; Stalke, Amelie; Dröge, Carola; Pfister, Evo-Doreen; Baumann, Ulrich; Luedde, Tom; Esposito, Irene; Keitel, Verena; Cantz, Tobias

A farnesoid X receptor T296I variant disrupts ligand-induced FXR activation and thus bile acid transport in progressive familial intrahepatic cholestasis.

法尼醇 X 受体 T296I 变体破坏配体诱导的 FXR 激活,从而破坏进行性家族性肝内胆汁淤积症中的胆汁酸转运。

Behrendt Annika, Bastianelli Alex, Stindt Jan, Pfister Eva-Doreen, Sgodda Malte, Cantz Tobias, Hook Sebastian, Gopalswamy Mohanraj, Grau Kathrin, Brands Stefanie, Dröge Carola, Stalke Amelie, Bonus Michele, Franke Sabine, Baumann Ulrich, Keitel Verena, Gohlke Holger

KIF12 Variants and Disturbed Hepatocyte Polarity in Children with a Phenotypic Spectrum of Cholestatic Liver Disease

胆汁淤积性肝病表型谱儿童的 KIF12 变异和肝细胞极性紊乱

Amelie Stalke, Malte Sgodda, Tobias Cantz, Britta Skawran, Elke Lainka, Björn Hartleben, Ulrich Baumann, Eva-Doreen Pfister

Synthetic Notch-Receptor-Mediated Transmission of a Transient Signal into Permanent Information via CRISPR/Cas9-Based Genome Editing

利用CRISPR/Cas9基因编辑技术,通过合成Notch受体介导的瞬时信号向永久信息的传递

Malte Sgodda ,Susanne Alfken ,Axel Schambach ,Reto Eggenschwiler ,Pawel Fidzinski ,Michael Hummel ,Tobias Cantz

Human germline editing in the era of CRISPR-Cas: risk and uncertainty, inter-generational responsibility, therapeutic legitimacy

CRISPR-Cas时代人类生殖细胞编辑:风险与不确定性、代际责任、治疗合法性

Schleidgen, Sebastian; Dederer, Hans-Georg; Sgodda, Susan; Cravcisin, Stefan; Lüneburg, Luca; Cantz, Tobias; Heinemann, Thomas

Chemically-Defined, Xeno-Free, Scalable Production of hPSC-Derived Definitive Endoderm Aggregates with Multi-Lineage Differentiation Potential

以化学方式定义、无异源物、可扩展的方式生产具有多谱系分化潜能的 hPSC 衍生定形内胚层聚集体

Anais Sahabian, Malte Sgodda, Ortwin Naujok, Rabea Dettmer, Julia Dahlmann, Felix Manstein, Tobias Cantz, Robert Zweigerdt, Ulrich Martin, Ruth Olmer

Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG)

患有磷酸甘露糖变位酶 2 先天性糖基化障碍 (PMM2-CDG) 的患者诱导性多能干细胞的糖组学特征

Christina T Thiesler, Samanta Cajic, Dirk Hoffmann, Christian Thiel, Laura van Diepen, René Hennig, Malte Sgodda, Robert Weiβmann, Udo Reichl, Doris Steinemann, Ulf Diekmann, Nicolas M B Huber, Astrid Oberbeck, Tobias Cantz, Andreas W Kuss, Christian Körner, Axel Schambach, Erdmann Rapp, Falk F R Bu

Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells

Wnt 信号的双相调节支持人类多能干细胞有效形成前肠内胚层

Jeannine Hoepfner, Mandy Kleinsorge, Oliver Papp, Mania Ackermann, Susanne Alfken, Ursula Rinas, Wladimir Solodenko, Andreas Kirschning, Malte Sgodda, Tobias Cantz

Sustained knockdown of a disease-causing gene in patient-specific induced pluripotent stem cells using lentiviral vector-based gene therapy

使用慢病毒载体基因治疗持续敲低患者特异性诱导多能干细胞中的致病基因

Reto Eggenschwiler, Komal Loya, Guangming Wu, Amar Deep Sharma, Malte Sgodda, Daniela Zychlinski, Christian Herr, Doris Steinemann, Jeffrey Teckman, Robert Bals, Michael Ott, Axel Schambach, Hans Robert Schöler, Tobias Cantz