日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The electrophilic metabolite of kynurenine, kynurenine-CKA, requires C151 in Keap1 to derepress Nrf2

犬尿氨酸的亲电代谢产物犬尿氨酸-CKA需要Keap1中的C151才能解除Nrf2的抑制。

Feng, Jialin; Carreño, Mara; Jung, Hannah; Dayalan Naidu, Sharadha; Arroyo-Diaz, Nicole; Ang, Abel D; Kulkarni, Bhargavi; Kisielewski, Dorothy; Suzuki, Takafumi; Yamamoto, Masayuki; Hayes, John D; Honda, Tadashi; Wilson, Landon; Leon-Ruiz, Beatriz; Eggler, Aimee L; Vitturi, Dario A; Dinkova-Kostova, Albena T

Keap1-Kelch-targeting protein-protein interaction inhibitors, but not reversibly-binding electrophiles, increase the thermostability of Keap1 in the cellular environment

靶向Keap1-Kelch的蛋白质-蛋白质相互作用抑制剂,而非可逆结合的亲电试剂,能够提高Keap1在细胞环境中的热稳定性。

Dayalan Naidu, Sharadha; Dikovskaya, Dina; Walker, Jasmine M; Yee, Charlotte Lim Jia; Cafferkey, Annamarie J; Tatsuno, Manaka; Feng, Jialin; Moore, Terry W; Johnson, Tatum; Honda, Tadashi; Wells, Geoff; Suzuki, Takafumi; Yamamoto, Masayuki; Dinkova-Kostova, Albena T

Health position paper and redox perspectives - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases

健康立场文件和氧化还原视角——非传染性疾病中NRF2药物调控的从实验室到临床转化

Cuadrado, Antonio; Cazalla, Eduardo; Bach, Anders; Bathish, Boushra; Naidu, Sharadha Dayalan; DeNicola, Gina M; Dinkova-Kostova, Albena T; Fernández-Ginés, Raquel; Grochot-Przeczek, Anna; Hayes, John D; Kensler, Thomas W; León, Rafael; Liby, Karen T; López, Manuela G; Manda, Gina; Shivakumar, Akshatha Kalavathi; Hakomäki, Henriikka; Moerland, Jessica A; Motohashi, Hozumi; Rojo, Ana I; Sykiotis, Gerasimos P; Taguchi, Keiko; Valverde, Ángela M; Yamamoto, Masayuki; Levonen, Anna-Liisa

Tetrazole-containing naphthalene bis-sulfonamide Keap1-Nrf2 interaction inhibitors with unexpected binding modes.

具有意想不到的结合模式的含四唑萘双磺酰胺 Keap1-Nrf2 相互作用抑制剂。

Georgakopoulos Nikolaos D, Talapatra Sandeep K, Dayalan Naidu Sharadha, Dikovskaya Dina, Higgins Maureen, Gatliff Jemma, Nikoloudaki Roxani, Schaap Marjolein, Walker Jasmine M, Wardby Christopher, Dinkova-Kostova Albena T, Harris Sarah, Kozielski Frank, Wells Geoff

Genetic Deletion of RHAMM Alleviates Hepatic Oxidative Stress, Reversing Thyroid Stimulating Hormone Elevation in Male Obese Mice

RHAMM基因缺失可减轻雄性肥胖小鼠的肝脏氧化应激,逆转促甲状腺激素水平升高

Wang, Tianzhen; Sun, Helin; Banah, Ayman K; Weng, Xiong; Dayalan Naidu, Sharadha; Kisielewski, Dot; Ang, Abel; Hayes, John D; Dinkova-Kostova, Albena T; Kang, Li

Association of men's contraceptive knowledge, attitude and behavior with modern contraceptive use: evidence from Nepal demographic health survey 2022

男性避孕知识、态度和行为与现代避孕方法使用之间的关联:来自2022年尼泊尔人口健康调查的证据

Shrestha, Vijaya Laxmi; Lamichhane, Kamala Devi; Hamal, Sharadha; Sapkota, Nanda Lal; Shrestha, Krishna Man

Do education and use of family planning methods empower women? Evidence from the Nepal Demographic Health Survey (NDHS) 2016 and 2022

教育和计划生育方法的使用是否能增强女性的能力?来自2016年和2022年尼泊尔人口与健康调查(NDHS)的证据

Shrestha, Bidhya; Gurung, Yogendra B; Shrestha, Tara Lal; Lamichhane, Kamala; Karki, Rita; Hamal, Sharadha

The electrophilic metabolite of kynurenine, kynurenine-CKA, targets C151 in Keap1 to derepress Nrf2

犬尿氨酸的亲电代谢产物犬尿氨酸-CKA靶向Keap1中的C151位点,从而解除Nrf2的抑制。

Feng, Jialin; Carreño, Mara; Jung, Hannah; Naidu, Sharadha Dayalan; Diaz, Nicole Arroyo; Ang, Abel D; Kulkarni, Bhargavi; Kisielewski, Dorothy; Suzuki, Takafumi; Yamamoto, Masayuki; Hayes, John D; Honda, Tadashi; Leon-Ruiz, Beatriz; Eggler, Aimee L; Vitturi, Dario A; Dinkova-Kostova, Albena T

Squidiff: Predicting cellular development and responses to perturbations using a diffusion model.

Squidiff:利用扩散模型预测细胞发育和对扰动的反应

He Siyu, Zhu Yuefei, Tavakol Daniel Naveed, Ye Haotian, Lao Yeh-Hsing, Zhu Zixian, Xu Cong, Chauhan Sharadha, Garty Guy, Tomer Raju, Vunjak-Novakovic Gordana, Zou James, Azizi Elham, Leong Kam W

Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms

骨骼肌中层粘连蛋白-α2链缺乏导致多种细胞机制失调

Susana G Martins, Vanessa Ribeiro, Catarina Melo, Cláudia Paulino-Cavaco, Dario Antonini, Sharadha Dayalan Naidu, Fernanda Murtinheira, Inês Fonseca, Bérénice Saget, Mafalda Pita, Diogo R Fernandes, Pedro Gameiro Dos Santos, Gabriela Rodrigues, Rita Zilhão, Federico Herrera, Albena T Dinkova-Kostova