日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of a Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader.

发现一种高效且选择性的蛋白质精氨酸甲基转移酶 5 (PRMT5) PROTAC 降解剂

Zhong Yue, Kim Huensuk, Qian Chao, Xie Ling, Chen Xian, Xiong Yan, Hu Jacqueline, Chen Matthew, Guccione Ernesto, Shen Yudao, Jin Jian

Epigenomic analysis identifies DTP subpopulation using HOPX to develop targeted therapy resistance in lung adenocarcinoma.

利用 HOPX 进行表观基因组分析,识别 DTP 亚群,从而在肺腺癌中产生靶向治疗耐药性

Tian Yang, Bhattacharya Reshmee, Yoo Seungyeul, Jiang Feng, Park Eric, Lara Granados Genesis, Shen Yudao, Park Kwang-Su, Kaniskan Husnu Umit, Jin Jian, Hopkins Benjamin D, Zhu Jun, Watanabe Hideo

Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic

发现一种双重WDR5和Ikaros PROTAC降解剂作为抗癌疗法

Li, Dongxu; Yu, Xufen; Kottur, Jithesh; Gong, Weida; Zhang, Zhao; Storey, Aaron J; Tsai, Yi-Hsuan; Uryu, Hidetaka; Shen, Yudao; Byrum, Stephanie D; Edmondson, Rick D; Mackintosh, Samuel G; Cai, Ling; Liu, Zhijie; Aggarwal, Aneel K; Tackett, Alan J; Liu, Jing; Jin, Jian; Wang, Gang Greg

A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models

一种选择性WDR5降解剂可抑制患者来源小鼠模型中的急性髓系白血病。

Yu, Xufen; Li, Dongxu; Kottur, Jithesh; Shen, Yudao; Kim, Huen Suk; Park, Kwang-Su; Tsai, Yi-Hsuan; Gong, Weida; Wang, Jun; Suzuki, Kyogo; Parker, Joel; Herring, Laura; Kaniskan, H Ümit; Cai, Ling; Jain, Rinku; Liu, Jing; Aggarwal, Aneel K; Wang, Gang Greg; Jin, Jian

Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia

靶向PRMT1介导的FLT3甲基化会破坏MLL重排急性淋巴细胞白血病的维持。

Zhu, Yinghui; He, Xin; Lin, Yi-Chun; Dong, Haojie; Zhang, Lei; Chen, Xianwei; Wang, Zhihao; Shen, Yudao; Li, Min; Wang, Hanying; Sun, Jie; Nguyen, Le Xuan; Zhang, Han; Jiang, Wenjuan; Yang, Yanzhong; Chen, Jianjun; Müschen, Markus; Chen, Chun-Wei; Konopleva, Marina Y; Sun, Weili; Jin, Jian; Carlesso, Nadia; Marcucci, Guido; Luo, Yun; Li, Ling

PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD(+) acute myeloid leukemia

PRMT1介导的FLT3精氨酸甲基化促进FLT3-ITD(+)急性髓系白血病的维持

He, Xin; Zhu, Yinghui; Lin, Yi-Chun; Li, Min; Du, Juan; Dong, Haojie; Sun, Jie; Zhu, Lei; Wang, Hanying; Ding, Zonghui; Zhang, Lei; Zhang, Lianjun; Zhao, Dandan; Wang, Zhihao; Wu, Herman; Zhang, Han; Jiang, Wenjuan; Xu, Yang; Jin, Jian; Shen, Yudao; Perry, Jeff; Zhao, Xinyang; Zhang, Bin; Liu, Songbai; Xue, Sheng-Li; Shen, Binghui; Chen, Chun-Wei; Chen, Jianjun; Khaled, Samer; Kuo, Ya-Huei; Marcucci, Guido; Luo, Yun; Li, Ling