Discovery of potent and selective HPK1 inhibitors based on the 2,4-disubstituted pyrimidine scaffold with immune modulatory properties for ameliorating T cell exhaustion
发现基于 2,4-二取代嘧啶骨架的强效选择性 HPK1 抑制剂,具有免疫调节特性,可改善 T 细胞衰竭
期刊:Bioorganic Chemistry
影响因子:4.5
doi:10.1016/j.bioorg.2023.106728
Shenxin Zeng, Ming Zeng, Shuai Yuan, Liuxun He, Yuyuan Jin, Jiandong Huang, Manxuan Zhang, Menghan Yang, Youlu Pan, Zunyuan Wang, Yinqiao Chen, Xiangwei Xu, Wenhai Huang