日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy

肝细胞内在 SMN 缺乏导致脊髓性肌萎缩症中的代谢功能障碍和肝脏脂肪变性

Damien Meng-Kiat Leow, Yang Kai Ng, Loo Chien Wang, Hiromi Wl Koh, Tianyun Zhao, Zi Jian Khong, Tommaso Tabaglio, Gunaseelan Narayanan, Richard M Giadone, Radoslaw M Sobota, Shi-Yan Ng, Adrian Kk Teo, Simon H Parson, Lee L Rubin, Wei-Yi Ong, Basil T Darras, Crystal Jj Yeo

SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease

SMN 缺失小鼠可作为非酒精性脂肪肝疾病的稳健且快速发病模型

Marc-Olivier Deguise, Chantal Pileggi, Yves De Repentigny, Ariane Beauvais, Alexandra Tierney, Lucia Chehade, Jean Michaud, Maica Llavero-Hurtado, Douglas Lamont, Abdelmadjid Atrih, Thomas M Wishart, Thomas H Gillingwater, Bernard L Schneider, Mary-Ellen Harper, Simon H Parson, Rashmi Kothary

Widespread tissue hypoxia dysregulates cell and metabolic pathways in SMA

广泛的组织缺氧导致 SMA 中的细胞和代谢途径失调

Elena Hernandez-Gerez, Sergio Dall'Angelo, Jon M Collinson, Ian N Fleming, Simon H Parson

Lamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy

层蛋白 A/C 失调导致严重脊髓性肌萎缩症小鼠模型出现心脏病理

Darija Šoltić, Hannah K Shorrock, Hazel Allardyce, Emma L Wilson, Ian Holt, Silvia A Synowsky, Sally L Shirran, Simon H Parson, Thomas H Gillingwater, Heidi R Fuller

Developmental and degenerative cardiac defects in the Taiwanese mouse model of severe spinal muscular atrophy

台湾严重脊髓性肌萎缩症小鼠模型的发育和退行性心脏缺陷

Gillian K Maxwell, Eva Szunyogova, Hannah K Shorrock, Thomas H Gillingwater, Simon H Parson

Survival of motor neurone protein is required for normal postnatal development of the spleen

运动神经元蛋白的存活是脾脏出生后正常发育的必要条件

Alison K Thomson, Eilidh Somers, Rachael A Powis, Hannah K Shorrock, Kelley Murphy, Kathryn J Swoboda, Thomas H Gillingwater, Simon H Parson

Vascular Defects and Spinal Cord Hypoxia in Spinal Muscular Atrophy

脊髓性肌萎缩症中的血管缺陷和脊髓缺氧

Eilidh Somers, Robert D Lees, Katie Hoban, James N Sleigh, Haiyan Zhou, Francesco Muntoni, Kevin Talbot, Thomas H Gillingwater, Simon H Parson

Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy

系统性恢复 UBA1 可改善脊髓性肌萎缩症

Rachael A Powis, Evangelia Karyka, Penelope Boyd, Julien Côme, Ross A Jones, Yinan Zheng, Eva Szunyogova, Ewout Jn Groen, Gillian Hunter, Derek Thomson, Thomas M Wishart, Catherina G Becker, Simon H Parson, Cécile Martinat, Mimoun Azzouz, Thomas H Gillingwater

Survival Motor Neuron (SMN) protein is required for normal mouse liver development

生存运动神经元 (SMN) 蛋白是小鼠肝脏正常发育所必需的

Eva Szunyogova, Haiyan Zhou, Gillian K Maxwell, Rachael A Powis, Francesco Muntoni, Thomas H Gillingwater, Simon H Parson

Histopathological Defects in Intestine in Severe Spinal Muscular Atrophy Mice Are Improved by Systemic Antisense Oligonucleotide Treatment

系统性反义寡核苷酸治疗可改善重度脊髓性肌萎缩症小鼠肠道组织病理学缺陷

Palittiya Sintusek, Francesco Catapano, Napat Angkathunkayul, Elena Marrosu, Simon H Parson, Jennifer E Morgan, Francesco Muntoni, Haiyan Zhou