日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Capacity for Compensatory Cyclin D2 Response Confers Trametinib Resistance in Canine Mucosal Melanoma

代偿性细胞周期蛋白D2反应能力赋予犬黏膜黑色素瘤曲美替尼耐药性

Wei, Bih-Rong; Verdi, Vincenzo; Zhang, Shuling; Mock, Beverly A; Shive, Heather R; Simpson, R Mark

Capacity for compensatory cyclin D2 response confers trametinib resistance in canine mucosal melanoma

代偿性细胞周期蛋白D2反应能力赋予犬黏膜黑色素瘤曲美替尼耐药性

Wei, Bih-Rong; Verdi, Vincenzo; Zhang, Shuling; Mock, Beverly A; Shive, Heather R; Simpson, R Mark

Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis.

短暂的雪旺细胞前体和混合状态是黑色素瘤治疗耐药性和转移的基础

Gopalan Vishaka, Wong Chun Wai, Leshem Rotem, Owen Luke, Vallius Tuulia, Shi Yingxiao, Jiang Yuhong, Pérez-Guijarro Eva, Wu Emily, Chin Sung, Ebersole Jessica, Smith Cari, Sassano Antonella, Constantino Maira Alves, Haley Michael J, Livak Ferenc, Simpson R Mark, Day Chi-Ping, Hurlstone Adam, Hannenhalli Sridhar, Merlino Glenn, Marie Kerrie L

Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma

高通量筛选发现的药物组合可促进骨髓瘤细胞周期转换并上调Smad通路。

Peat, Tyler J; Gaikwad, Snehal M; Dubois, Wendy; Gyabaah-Kessie, Nana; Zhang, Shuling; Gorjifard, Sayeh; Phyo, Zaw; Andres, Megan; Hughitt, V Keith; Simpson, R Mark; Miller, Margaret A; Girvin, Andrew T; Taylor, Andrew; Williams, Daniel; D'Antonio, Nelson; Zhang, Yong; Rajagopalan, Adhithi; Flietner, Evan; Wilson, Kelli; Zhang, Xiaohu; Shinn, Paul; Klumpp-Thomas, Carleen; McKnight, Crystal; Itkin, Zina; Chen, Lu; Kazandijian, Dickran; Zhang, Jing; Michalowski, Aleksandra M; Simmons, John K; Keats, Jonathan; Thomas, Craig J; Mock, Beverly A

CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development

肺癌细胞中CCL5的产生会导致免疫微环境改变,并促进肿瘤发展。

Melese, Etienne S; Franks, Elizabeth; Cederberg, Rachel A; Harbourne, Bryant T; Shi, Rocky; Wadsworth, Brennan J; Collier, Jenna L; Halvorsen, Elizabeth C; Johnson, Fraser; Luu, Jennifer; Oh, Min Hee; Lam, Vivian; Krystal, Gerald; Hoover, Shelley B; Raffeld, Mark; Simpson, R Mark; Unni, Arun M; Lam, Wan L; Lam, Stephen; Abraham, Ninan; Bennewith, Kevin L; Lockwood, William W

Pharmacokinetics and tolerability of the dual TORC1/2 inhibitor sapanisertib in combination with the MEK inhibitor trametinib in dogs

犬体内双重TORC1/2抑制剂sapanisertib联合MEK抑制剂trametinib的药代动力学和耐受性研究

Wei, Bih-Rong; Peer, Cody J; Richardson, William J; Hewitt, Stephen M; Figg, William D; Simpson, R Mark

The Outcome of TGFβ Antagonism in Metastatic Breast Cancer Models In Vivo Reflects a Complex Balance between Tumor-Suppressive and Proprogression Activities of TGFβ

体内转移性乳腺癌模型中TGFβ拮抗剂的作用结果反映了TGFβ抑癌活性和促进展活性之间复杂的平衡

Yang, Yuan; Yang, Howard H; Tang, Binwu; Wu, Alex Man Lai; Flanders, Kathleen C; Moshkovich, Nellie; Weinberg, Douglas S; Welsh, Michael A; Weng, Jia; Ochoa, Humberto J; Hu, Tiffany Y; Herrmann, Michelle A; Chen, Jinqiu; Edmondson, Elijah F; Simpson, R Mark; Liu, Fang; Liu, Huaitian; Lee, Maxwell P; Wakefield, Lalage M

Efficacy, Tolerability, and Pharmacokinetics of Combined Targeted MEK and Dual mTORC1/2 Inhibition in a Preclinical Model of Mucosal Melanoma

在黏膜黑色素瘤临床前模型中,联合靶向MEK和双重mTORC1/2抑制的疗效、耐受性和药代动力学研究

Wei, Bih-Rong; Hoover, Shelley B; Peer, Cody J; Dwyer, Jennifer E; Adissu, Hibret A; Shankarappa, Priya; Yang, Howard; Lee, Maxwell; Peat, Tyler J; Figg, William D; Simpson, R Mark

Agreement in Histological Assessment of Mitotic Activity Between Microscopy and Digital Whole Slide Images Informs Conversion for Clinical Diagnosis

显微镜和数字全切片图像在有丝分裂活性组织学评估方面的一致性为临床诊断提供了依据

Wei, Bih-Rong; Halsey, Charles H; Hoover, Shelley B; Puri, Munish; Yang, Howard H; Gallas, Brandon D; Lee, Maxwell P; Chen, Weijie; Durham, Amy C; Dwyer, Jennifer E; Sánchez, Melissa D; Traslavina, Ryan P; Frank, Chad; Bradley, Charles; McGill, Lawrence D; Esplin, D Glen; Schaffer, Paula A; Cramer, Sarah D; Lyle, L Tiffany; Beck, Jessica; Buza, Elizabeth; Gong, Qi; Hewitt, Stephen M; Simpson, R Mark

Naturally Occurring Canine Melanoma as a Predictive Comparative Oncology Model for Human Mucosal and Other Triple Wild-Type Melanomas

自然发生的犬黑色素瘤作为人类黏膜和其他三重野生型黑色素瘤的预测性比较肿瘤学模型

Hernandez, Belen; Adissu, Hibret A; Wei, Bih-Rong; Michael, Helen T; Merlino, Glenn; Simpson, R Mark