日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A placebo-controlled, multiple ascending dose study to evaluate the safety, pharmacokinetics and pharmacodynamics of avagacestat (BMS-708163) in healthy young and elderly subjects

一项安慰剂对照、多次递增剂量研究，旨在评估阿伐加司他 (BMS-708163) 在健康年轻和老年受试者中的安全性、药代动力学和药效学

期刊:Clinical Pharmacokinetics
影响因子:4.6
doi:10.1007/s40262-012-0005-x
Randy Dockens, Jun-Sheng Wang, Lorna Castaneda, Oleksandr Sverdlov, Shu-Pang Huang, Randy Slemmon, Huidong Gu, Oi Wong, Hewei Li, Robert M Berman, Christina Smith, Charles F Albright, Gary Tong
多发性硬化症
发表日期：2024
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Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163 (Avagacestat): tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers

口服 γ-分泌酶抑制剂 BMS-708163（Avagacestat）的多中心、随机、双盲、安慰剂对照、单次递增剂量研究：耐受性概况、药代动力学参数和药效学标志物

期刊:Clinical Therapeutics
影响因子:3.2
doi:10.1016/j.clinthera.2012.01.022
Gary Tong, Jun-Sheng Wang, Oleksandr Sverdlov, Shu-Pang Huang, Randy Slemmon, Robert Croop, Lorna Castaneda, Huidong Gu, Oi Wong, Hewei Li, Robert M Berman, Christina Smith, Charles F Albright, Randy C Dockens
信号转导
JAK/STAT
发表日期：2024
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Effects of single doses of avagacestat (BMS-708163) on cerebrospinal fluid Aβ levels in healthy young men

单剂量阿伐加塞司他（BMS-708163）对健康年轻男性脑脊液 Aβ 水平的影响

期刊:Clinical Drug Investigation
影响因子:2.9
doi:10.1007/s40261-012-0006-4
Gary Tong, Lorna Castaneda, Jun-Sheng Wang, Oleksandr Sverdlov, Shu-Pang Huang, Randy Slemmon, Huidong Gu, Oi Wong, Hewei Li, Robert M Berman, Christina Smith, Charles Albright, Randy C Dockens
多发性硬化症
神经科学
发表日期：2024
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Profiling classical neuropsychiatric biomarkers across biological fluids and following continuous lumbar puncture: A guide to sample type and time.

对生物体液中的经典神经精神生物标志物进行分析，并进行连续腰椎穿刺：样本类型和时间指南

期刊:Comprehensive Psychoneuroendocrinology
影响因子:2.5
doi:10.1016/j.cpnec.2022.100116
Triana-Baltzer Gallen, Timmers Maarten, De Boer Peter, Schoene Manja, Furey Maura, Bleys Cathy, Vrancken Isabeau, Slemmon Randy, Ceusters Marc, van Nueten Luc, Kolb Hartmuth
神经科学
发表日期：2022
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Time Trends of Cerebrospinal Fluid Biomarkers of Neurodegeneration in Idiopathic Normal Pressure Hydrocephalus

特发性正常压力脑积水患者脑脊液神经退行性变生物标志物的时间趋势

期刊:Journal of Alzheimers Disease
影响因子:3.1
doi:10.3233/JAD-201361
Lukkarinen, Heikki; Tesseur, Ina; Pemberton, Darrel; Van Der Ark, Peter; Timmers, Maarten; Slemmon, Randy; Janssens, Luc; Streffer, Johannes; Van Nueten, Luc; Bottelbergs, Astrid; Rauramaa, Tuomas; Koivisto, Anne M; Herukka, Sanna-Kaisa; Korhonen, Ville E; Junkkari, Antti; Hiltunen, Mikko; Engelborghs, Sebastiaan; Blennow, Kaj; Zetterberg, Henrik; Kolb, Hartmuth C; Leinonen, Ville
神经科学
发表日期：2021
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Development and validation of a high-sensitivity assay for measuring p217+tau in plasma

开发并验证一种用于测量血浆中 p217+tau 的高灵敏度检测方法

期刊:Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
影响因子:
doi:10.1002/dad2.12204
Gallen Triana-Baltzer, Setareh Moughadam, Randy Slemmon, Kristof Van Kolen, Clara Theunis, Marc Mercken, Hartmuth C Kolb
信号转导
发表日期：2021
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Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease

脑脊液 p-tau217 作为阿尔茨海默病的生物标志物效果优于 p-tau181

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-020-15436-0
Shorena Janelidze, Erik Stomrud, Ruben Smith, Sebastian Palmqvist, Niklas Mattsson, David C Airey, Nicholas K Proctor, Xiyun Chai, Sergey Shcherbinin, John R Sims, Gallen Triana-Baltzer, Clara Theunis, Randy Slemmon, Marc Mercken, Hartmuth Kolb, Jeffrey L Dage, Oskar Hansson1
神经科学
阿尔茨海默症
发表日期：2020
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Development and Validation of a High Sensitivity Assay for Measuring p217 + tau in Cerebrospinal Fluid

开发和验证一种用于测量脑脊液中 p217 + tau 的高灵敏度检测方法

期刊:Journal of Alzheimers Disease
影响因子:3.4
doi:10.3233/JAD-200463
Gallen Triana-Baltzer, Kristof Van Kolen, Clara Theunis, Setareh Moughadam, Randy Slemmon, Marc Mercken, Wendy Galpern, Hong Sun, Hartmuth Kolb
信号转导
发表日期：2020
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BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants

使用 BACE 抑制剂抑制 BACE1 后其动态变化及其与老年健康参与者下游阿尔茨海默病标志物的相关性

期刊:Journal of Alzheimers Disease
影响因子:3.1
doi:10.3233/JAD-160829
Timmers, Maarten; Barão, Soraia; Van Broeck, Bianca; Tesseur, Ina; Slemmon, John; De Waepenaert, Katja; Bogert, Jennifer; Shaw, Leslie M; Engelborghs, Sebastiaan; Moechars, Dieder; Mercken, Marc; Van Nueten, Luc; Tritsmans, Luc; de Strooper, Bart; Streffer, Johannes Rolf
BACE1
阿尔茨海默症
发表日期：2017
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Impact of frequent cerebrospinal fluid sampling on Aβ levels: systematic approach to elucidate influencing factors

频繁脑脊液采样对Aβ水平的影响：阐明影响因素的系统方法

期刊:Alzheimers Research & Therapy
影响因子:7.6
doi:10.1186/s13195-016-0184-z
Van Broeck, Bianca; Timmers, Maarten; Ramael, Steven; Bogert, Jennifer; Shaw, Leslie M; Mercken, Marc; Slemmon, John; Van Nueten, Luc; Engelborghs, Sebastiaan; Streffer, Johannes Rolf
神经科学
发表日期：2016
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