日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Long-acting intramuscular injections of ELQ-331, an antimalarial agent

长效肌注抗疟药ELQ-331

Karunakaran, Dipu; Mutyam, Shravan K; Fu, Melody; Chen, Jiaming; Pham, Kim Hue Nicky; Pou, Sovitj; Winter, Rolf W; Nilsen, Aaron; Dodean, Rozalia A; Smilkstein, Martin J; Riscoe, Michael K; Shankar, Gita

3-Position Biaryl Endochin-like Quinolones with Enhanced Antimalarial Performance

具有增强抗疟性能的3位联芳基内切辛类喹诺酮

Pou, Sovitj; Winter, Rolf W; Dodean, Rozalia A; Liebman, Katherine; Li, Yuexin; Mather, Michael W; Nepal, Binod; Nilsen, Aaron; Handford, Mason J; Riscoe, Teresa M; Laxson, Sydney; Kirtley, Payton J; Aleshnick, Maya; Zakharov, Lev N; Kelly, Jane X; Smilkstein, Martin J; Wilder, Brandon K; Kortagere, Sandhya; Vaidya, Akhil B; Alday, P Holland; Doggett, J Stone; Riscoe, Michael K

Atypical Molecular Basis for Drug Resistance to Mitochondrial Function Inhibitors in Plasmodium falciparum

恶性疟原虫对线粒体功能抑制剂产生耐药性的非典型分子基础

Heather J Painter, Joanne M Morrisey, Michael W Mather, Lindsey M Orchard, Cuyler Luck, Martin J Smilkstein, Michael K Riscoe, Akhil B Vaidya, Manuel Llinás

ELQ-331 as a prototype for extremely durable chemoprotection against malaria

ELQ-331 作为一种针对疟疾的超持久化学保护剂的原型

Smilkstein, Martin J; Pou, Sovitj; Krollenbrock, Alina; Bleyle, Lisa A; Dodean, Rozalia A; Frueh, Lisa; Hinrichs, David J; Li, Yuexin; Martinson, Thomas; Munar, Myrna Y; Winter, Rolf W; Bruzual, Igor; Whiteside, Samantha; Nilsen, Aaron; Koop, Dennis R; Kelly, Jane X; Kappe, Stefan H I; Wilder, Brandon K; Riscoe, Michael K

Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc(1) and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis

对内切辛类喹诺酮类化合物的靶向构效关系分析揭示了弓形虫和恶性疟原虫细胞色素bc1的强效Qi和Qo位点抑制剂,并鉴定出ELQ-400是一种对急性实验性弓形虫病具有显著疗效的化合物。

McConnell, Erin V; Bruzual, Igor; Pou, Sovitj; Winter, Rolf; Dodean, Rozalia A; Smilkstein, Martin J; Krollenbrock, Alina; Nilsen, Aaron; Zakharov, Lev N; Riscoe, Michael K; Doggett, J Stone

Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based Drugs

简化的反向氯喹可克服疟疾对喹啉类药物的耐药性

Gunsaru, Bornface; Burgess, Steven J; Morrill, Westin; Kelly, Jane X; Shomloo, Shawheen; Smilkstein, Martin J; Liebman, Katherine; Peyton, David H

Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria

阿托伐醌和ELQ-300联合疗法作为一种新型双位点细胞色素bc1抑制策略治疗疟疾

Stickles, Allison M; Smilkstein, Martin J; Morrisey, Joanne M; Li, Yuexin; Forquer, Isaac P; Kelly, Jane X; Pou, Sovitj; Winter, Rolf W; Nilsen, Aaron; Vaidya, Akhil B; Riscoe, Michael K

Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro

甲氟喹和拟精神病药在体外具有神经递质受体和转运蛋白相互作用

Aaron Janowsky, Amy J Eshleman, Robert A Johnson, Katherine M Wolfrum, David J Hinrichs, Jongtae Yang, T Mark Zabriskie, Martin J Smilkstein, Michael K Riscoe

A drug-selected Plasmodium falciparum lacking the need for conventional electron transport

一种经药物筛选的恶性疟原虫,其无需传统的电子传递途径。

Smilkstein, Martin J; Forquer, Isaac; Kanazawa, Atsuko; Kelly, Jane Xu; Winter, Rolf W; Hinrichs, David J; Kramer, David M; Riscoe, Michael K

Antimalarial quinolones: synthesis, potency, and mechanistic studies

抗疟喹诺酮类药物:合成、效力和机理研究

Rolf W Winter, Jane X Kelly, Martin J Smilkstein, Rozalia Dodean, David Hinrichs, Michael K Riscoe