日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions

在银屑病条件下，产生白细胞介素-17的γδ T细胞的代谢重编程促进ACC1介导的从头脂肪生成。

期刊:Nature Metabolism
影响因子:20.8
doi:10.1038/s42255-025-01276-z
Kao, Yu-San; Lauterbach, Mario; Lopez Krol, Aleksandra; Distler, Ute; Godoy, Gloria Janet; Klein, Matthias; Argüello, Rafael Jose; Boukhallouk, Fatima; Vallejo Fuente, Sara; Braband, Kathrin Luise; Nurbekova, Assel; Romero, Monica; Mamareli, Panagiota; Silva, Luana; Damasceno, Luis Eduardo Alves; Rampoldi, Francesca; Berod, Luciana; Lynch, Lydia; Hiller, Karsten; Sparwasser, Tim
T细胞
银屑病
代谢
代谢重编程
T细胞
细胞生物学
免疫/内分泌
发表日期：2025
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Acetyl-CoA carboxylase 1 inhibition increases Treg metabolism and graft-versus-host disease treatment efficacy via mitochondrial fusion

乙酰辅酶A羧化酶1抑制剂通过线粒体融合增强Treg细胞代谢和移植物抗宿主病治疗效果。

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI182480
McDonald-Hyman, Cameron; Aguilar, Ethan G; Compeer, Ewoud B; Zaiken, Michael C; Rhee, Stephanie Y; Mohamed, Fathima A; Larson, Jemma H; Loschi, Michael L; Lees, Christopher; Thangavelu, Govindarajan; Sleeth, Margaret L; Smith, Kyle D; Whangbo, Jennifer S; Ritz, Jerome; Sparwasser, Tim D; O'Connor, Roddy S; Crawford, Peter A; Rathmell, Jeffrey C; Kean, Leslie S; Zeiser, Robert; Hippen, Keli L; Dustin, Michael L; Blazar, Bruce R
T细胞
代谢
Treg
线粒体
细胞生物学
发表日期：2025
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ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance.

ACC1 是 Treg 稳定性和免疫耐受性的双重代谢-表观遗传调节因子

期刊:Molecular Metabolism
影响因子:6.6
doi:10.1016/j.molmet.2025.102111
Stüve Philipp, Godoy Gloria J, Ferreyra Fernando N, Hellriegel Florencia, Boukhallouk Fatima, Kao Yu-San, More Tushar H, Matthies Anne-Marie, Akimova Tatiana, Abraham Wolf-Rainer, Kaever Volkhard, Schmitz Ingo, Hiller Karsten, Lochner Matthias, Salomon Benoît L, Beier Ulf H, Rehli Michael, Sparwasser Tim, Berod Luciana
代谢
表观遗传
T细胞
发表日期：2025
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The Streptomyces Metabolite Thiostrepton Inhibits Regulatory T Cell Differentiation and Function to Boost Antitumor Immune Responses.

链霉菌代谢产物硫链丝菌素抑制调节性 T 细胞分化和功能，从而增强抗肿瘤免疫反应

期刊:European Journal of Immunology
影响因子:3.7
doi:10.1002/eji.70035
Silva Luana, Almeida Luís, Al-Naimi Fatima, Nascimento Daniele Carvalho, Lopez Krol Aleksandra, Damasceno Luis Eduardo Alves, Echchannaoui Hakim, Alves-Filho José Carlos, Berod Luciana, Sparwasser Tim
代谢
肿瘤
肿瘤免疫
发表日期：2025
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TLR9-Driven S-Palmitoylation in Dendritic Cells Reveals Immune and Metabolic Protein Targets.

TLR9驱动的树突状细胞S-棕榈酰化揭示了免疫和代谢蛋白靶点

期刊:European Journal of Immunology
影响因子:3.7
doi:10.1002/eji.70039
Quiroz Juan N, Sielaff Malte, Kondrateva Daria, Boukhallouk Fatima, Godoy Gloria J, Molina Cecilia R, Moonen Brecht, Motran Claudia C, Bogie Jeroen, Luján Hugo D, Tenzer Stefan, Sparwasser Tim, Berod Luciana
代谢
细胞生物学
发表日期：2025
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Efficient and Selective Biosynthesis of a Precursor-Directed FK506 Analogue: Paving the Way for Click Chemistry

高效选择性地生物合成前体导向的FK506类似物：为点击化学铺平道路

期刊:Journal of Natural Products
影响因子:3.6
doi:10.1021/acs.jnatprod.4c00394
Goranovič, Dušan; Jenko, Branko; Ramšak, Barbara; Podgoršek Berke, Ajda; Bedrač, Leon; Horvat, Jaka; Šala, Martin; Makuc, Damjan; Carriche, Guilhermina M; Silva, Luana; Lopez Krol, Aleksandra; Pšeničnik, Alen; Durán Alonso, María Beatriz; Avbelj, Martina; Stavber, Stojan; Plavec, Janez; Sparwasser, Tim; Müller, Rolf; Kosec, Gregor; Fujs, Štefan; Petković, Hrvoje
发表日期：2025
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Adsorption of antigen to polymeric nanoparticles enhances cytotoxic T-cell responses and anti-tumor immunity by targeting conventional type 1 dendritic cells

抗原吸附到聚合物纳米颗粒上可通过靶向常规1型树突状细胞来增强细胞毒性T细胞反应和抗肿瘤免疫。

期刊:Immunology and Cell Biology
影响因子:3
doi:10.1111/imcb.70049
Huete-Carrasco, Jorge; Zhu, Jingjing; Van den Eynde, Benoit J; Mayer, Christian Thomas; Sparwasser, Tim; Ward, Ross W; Lavelle, Ed C
肿瘤
T细胞
肿瘤免疫
树突状细胞
T细胞
细胞生物学
毒理研究
树突状细胞
免疫/内分泌
发表日期：2025
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Perioperative stroke deteriorates white matter integrity by enhancing cytotoxic CD8(+) T-cell activation

围手术期卒中通过增强细胞毒性CD8(+) T细胞活化来破坏白质完整性。

期刊:CNS Neuroscience & Therapeutics
影响因子:5
doi:10.1111/cns.14747
Zhou, Yuxi; Wang, Xin; Yin, Wen; Li, Yan; Guo, Yunlu; Chen, Chen; Boltze, Johannes; Liesz, Arthur; Sparwasser, Tim; Wen, Daxiang; Yu, Weifeng; Li, Peiying
T细胞
CD8
T细胞
细胞生物学
毒理研究
免疫/内分泌
发表日期：2024
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Transient Depletion of Foxp3(+) Regulatory T Cells Selectively Promotes Aggressive β Cell Autoimmunity in Genetically Susceptible DEREG Mice

Foxp3(+)调节性T细胞的瞬时耗竭选择性地促进遗传易感DEREG小鼠的侵袭性β细胞自身免疫

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2021.720133
Watts, Deepika; Janßen, Marthe; Jaykar, Mangesh; Palmucci, Francesco; Weigelt, Marc; Petzold, Cathleen; Hommel, Angela; Sparwasser, Tim; Bonifacio, Ezio; Kretschmer, Karsten
细胞生物学
T细胞
T细胞
免疫/内分泌
发表日期：2021
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Correction: TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice

更正：树突状细胞激活TGFβ可诱导Th17细胞增殖和肠道收缩，并增强小鼠体内旋毛虫的排出。

期刊:PLoS Pathogens
影响因子:4.9
doi:10.1371/journal.ppat.1010063
Steel, Nicola; Faniyi, Aduragbemi A; Rahman, Sayema; Swietlik, Stefanie; Czajkowska, Beata I; Chan, Bethany T; Hardgrave, Alexander; Steel, Anthony; Sparwasser, Tim D; Assas, Mushref B; Grencis, Richard K; Travis, Mark A; Worthington, John J
树突状细胞
细胞生物学
TGFβ
树突状细胞
免疫/内分泌
发表日期：2021
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