日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Small molecule-directed differentiation of submerged-cultured human nasal airway epithelia for respiratory disease modeling

利用小分子定向分化浸没培养的人鼻气道上皮细胞用于呼吸系统疾病建模

Dreyer, Henriette H M; Ithakisiou, Georgia-Nefeli; Spelier, Sacha; Iwanski, Malina K; Katrukha, Eugene; Terstappen, Jonne; Rodenburg, Lisa W; Shekhar, Aditi; den Hertog-Oosterhoff, Loes A; Smits, Shannon M A; van der Windt, Isabelle S; Azink, Lotte T; Bijlard, Linda H M; Passier, Koen; van Beuningen, Sam F B; Lebbink, Robert Jan; Haarman, Eric G; van der Ent, Cornelis K; Kapitein, Lukas C; Bont, Louis J; Beekman, Jeffrey M; Amatngalim, Gimano D

Patient-Derived Intestinal Organoids in the Global Cystic Fibrosis Landscape

全球囊性纤维化领域中患者来源的肠道类器官

Kroes, Suzanne; Taylor-Cousar, Jennifer L; Zampoli, Marco; Karadag, Bülent; van der Ent, Cornelis K; de Winter-de Groot, Karin M; Beekman, Jeffrey M; Spelier, Sacha

ACE-tRNAs are a platform technology for suppressing nonsense mutations that cause cystic fibrosis.

ACE-tRNA 是一种用于抑制导致囊性纤维化的无义突变的平台技术

Ko Wooree, Porter Joseph J, Spelier Sacha, Sorensen Emily G, Bhatt Priyanka, Gabell Jeffrey T, van der Windt Isabelle, Couch Tyler, Coote Kevin, Mense Martin, Beekman Jeffrey M, Lueck John D

The Promising Role of Intestinal Organoids in the Diagnostic Work-Up of Cystic Fibrosis Screen Positive Inconclusive Diagnosis/CFTR-Related Metabolic Syndrome (CFSPID/CRMS)

肠道类器官在囊性纤维化筛查阳性但诊断不确定/CFTR相关代谢综合征(CFSPID/CRMS)诊断工作中的潜在作用

Rodriguez Mier, Noelia; Destoop, Marlies; Spelier, Sacha; Ramalho, Anabela Santo; Beekman, Jeffrey M; Vermeulen, François; de Winter-de Groot, Karin M; Proesmans, Marijke

Organoid-guided synergistic treatment of minimal function CFTR mutations with CFTR modulators, roflumilast and simvastatin: a personalised approach

利用类器官引导的CFTR调节剂、罗氟司特和辛伐他汀协同治疗功能极低的CFTR突变:一种个体化方法

Spelier, Sacha; de Winter-de Groot, Karin; Keijzer-Nieuwenhuijze, Natascha; Liem, Yves; van der Ent, Kors; Beekman, Jeffrey; Kamphuis, Lieke S

Use of 2,6-diaminopurine as a potent suppressor of UGA premature stop codons in cystic fibrosis

使用 2,6-二氨基嘌呤作为囊性纤维化中 UGA 过早终止密码子的强效抑制剂

Catherine Leroy, Sacha Spelier, Nadège Charlene Essonghe, Virginie Poix, Rebekah Kong, Patrick Gizzi, Claire Bourban, Séverine Amand, Christine Bailly, Romain Guilbert, David Hannebique, Philippe Persoons, Gwenaëlle Arhant, Anne Prévotat, Philippe Reix, Dominique Hubert, Michèle Gérardin, Mathias Ch

High-throughput functional assay in cystic fibrosis patient-derived organoids allows drug repurposing

囊性纤维化患者来源的类器官的高通量功能分析可实现药物再利用

Sacha Spelier, Eyleen de Poel, Georgia N Ithakisiou, Sylvia W F Suen, Marne C Hagemeijer, Danya Muilwijk, Annelotte M Vonk, Jesse E Brunsveld, Evelien Kruisselbrink, Cornelis K van der Ent, Jeffrey M Beekman

Mutation-specific reporter for optimization and enrichment of prime editing

用于优化和富集主要编辑的突变特异性报告基因

Schene, I F; Joore, I P; Baijens, J H L; Stevelink, R; Kok, G; Shehata, S; Ilcken, E F; Nieuwenhuis, E C M; Bolhuis, D P; van Rees, R C M; Spelier, S A; van der Doef, H P J; Beekman, J M; Houwen, R H J; Nieuwenhuis, E E S; Fuchs, S A

Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia

测量源自二维分化鼻上皮的类器官中的囊性纤维化药物反应

Gimano D Amatngalim, Lisa W Rodenburg, Bente L Aalbers, Henriette Hm Raeven, Ellen M Aarts, Dounia Sarhane, Sacha Spelier, Juliet W Lefferts, Iris Al Silva, Wilco Nijenhuis, Sacha Vrendenbarg, Evelien Kruisselbrink, Jesse E Brunsveld, Cornelis M van Drunen, Sabine Michel, Karin M de Winter-de Groot,

Predictive Value of EGFR-PI3K-AKT-mTOR-Pathway Inhibitor Biomarkers for Head and Neck Squamous Cell Carcinoma: A Systematic Review

EGFR-PI3K-AKT-mTOR通路抑制剂生物标志物对头颈部鳞状细胞癌的预测价值:系统评价

de Kort, W W B; Spelier, S; Devriese, L A; van Es, R J J; Willems, S M