日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The GENEVA platform models tumor mosaicism to reveal variations of responses to KRAS inhibitors and identify improved drug combinations

GENEVA平台通过模拟肿瘤嵌合现象,揭示KRAS抑制剂反应的差异,并识别更有效的药物组合。

Yu, Johnny X; Suh, Jung Min; Popova, Katerina D; Garcia, Kristle; Joshi, Tanvi; Culbertson, Bruce; Spinelli, Jessica B; Subramanyam, Vishvak; Lou, Kevin; Charbonneau, Trey; Shokat, Kevan M; Weissman, Jonathan; Goodarzi, Hani

Flip the fuel, and the heat is on! Carnitine synthesis as a physiological mediator of fuel adaptation

燃料切换,热力四射!肉碱合成作为燃料适应的生理调节因子

Hathiramani, Nicolai R; Jerrett, Alexandra E; Spinelli, Jessica B

Metabolic reprogramming during human neuron differentiation indicates glutaminase as a key determinant in Fragile X syndrome.

人类神经元分化过程中的代谢重编程表明谷氨酰胺酶是脆性X综合征的关键决定因素。

Shah Sneha, Barnes Daniel, Liu Botao, Tseyang Tenzin, Do Thang, Bubenik Jodi L, Jung Suna, Anadolu Mina N, Ivshina Maria P, Martínez-Cerdeño Verónica, Berry-Kravis Elizabeth, Swanson Maurice S, Spinelli Jessica B, Richter Joel D

A systems-level, semi-quantitative landscape of metabolic flux in C. elegans

秀丽隐杆线虫代谢通量的系统级半定量分析

Zhang, Hefei; Li, Xuhang; Tseyang, L Tenzin; Giese, Gabrielle E; Wang, Hui; Yao, Bo; Zhang, Jingyan; Neve, Rachel L; Shank, Elizabeth A; Spinelli, Jessica B; Yilmaz, L Safak; Walhout, Albertha J M

Rhodoquinone carries electrons in the mammalian electron transport chain.

红醌在哺乳动物电子传递链中携带电子

Valeros Jonathan, Jerome Madison, Tseyang Tenzin, Vo Paula, Do Thang, Fajardo Palomino Diana, Grotehans Nils, Kunala Manisha, Jerrett Alexandra E, Hathiramani Nicolai R, Mireku Michael, Magesh Rayna Y, Yenilmez Batuhan, Rosen Paul C, Mann Jessica L, Myers Jacob W, Kunchok Tenzin, Manning Tanner L, Boercker Lily N, Carr Paige E, Munim Muhammad Bin, Lewis Caroline A, Sabatini David M, Kelly Mark, Xie Jun, Czech Michael P, Gao Guangping, Shepherd Jennifer N, Walker Amy K, Kim Hahn, Watson Emma V, Spinelli Jessica B

Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity

对代谢酶磷酸化的结构和系统表征揭示了肥胖症中性别特异性的代谢重编程。

Tamir, Tigist Y; Chaudhary, Shreya; Li, Annie X; Trojan, Sonia E; Flower, Cameron T; Vo, Paula; Cui, Yufei; Davis, Jeffrey C; Mukkamala, Rachit; Venditti, Francesca N; Hillis, Alissandra L; Toker, Alex; Vander Heiden, Matthew G; Spinelli, Jessica B; Kennedy, Norman J; Davis, Roger J; White, Forest M

Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation.

再生肝脏利用氨来支持嘧啶从头合成和细胞增殖。

Endaya Berwini B, Kučera Lukáš, Le Dan-Diem Thi, Spinelli Jessica B, Brožková Andrea, Luptáková Dominika, Klíma Kryštof, Oliveira Gabriela L, Brisudová Petra, Boháčová Klára, Boukalová Štěpána, Zobalová Renata, Kolář František, Chalupsky Karel, Dohnalová Klára, Yarmohammadi-Barzegar Arash, Dvořáková Šárka, Biryukova Evgeniya, Kaliaeva Marta, Havlíček Vladimír, Sedláček Radislav, Procházka Jan, Vítek Libor, Park Sunghyouk, Martásek Pavel, Krška Zdeněk, Oliveira Paulo J, Berridge Michael V, Neužil Jiří

Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis.

MCJ/DnaJC15 的缺失会促进棕色脂肪组织产热

Cicuéndez Beatriz, Mora Alfonso, López Juan Antonio, Curtabbi Andrea, Pérez-García Javier, Porteiro Begoña, Jimenez-Blasco Daniel, Latorre-Muro Pedro, Vo Paula, Jerome Madison, Gómez-Santos Beatriz, Romero-Becerra Rafael, Leiva Magdalena, Rodríguez Elena, León Marta, Leiva-Vega Luis, Gómez-Lado Noemi, Torres Jorge L, Hernández-Cosido Lourdes, Aguiar Pablo, Marcos Miguel, Jastroch Martin, Daiber Andreas, Aspichueta Patricia, Bolaños Juan Pedro, Spinelli Jessica B, Puigserver Pere, Enriquez José Antonio, Vázquez Jesús, Folgueira Cintia, Sabio Guadalupe

Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation.

非整倍体导致核苷酸依赖性增强,并对代谢扰动更加敏感

Magesh Rayna Y, Kaur Arshia N, Keller Faith N, Frederick Abdulrazak, Tseyang Tenzin, Haley John A, Rivera-Nieves Alejandra M, Liang Anthony C, Guertin David A, Spinelli Jessica B, Elledge Stephen J, Watson Emma V

Distinct S-adenosylmethionine synthases link phosphatidylcholine to mitochondrial function and stress survival

不同的S-腺苷甲硫氨酸合成酶将磷脂酰胆碱与线粒体功能和应激生存联系起来

Munden, Athena L; Mushtaq, Arjamand; Lui, Dominique S; Edwards, Katherine M; Higgins, Daniel P; Biswas, Kasturi; Walker, Rachel M; Crowley, Leah H; Fanelli, Matthew J; Ngyuen, Thien-Kim; Ericsson, Maria; Godbole, Adwait A; Haley, John A; Lewis, Caroline A; Spinelli, Jessica B; Harrison, Benjamin; Raftery, Daniel; Djukovic, Danijel; Promislow, Daniel E L; Miller, Dana L; Walker, Amy K