日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Determinants of Surgical Outcomes in Tricuspid Valve Endocarditis

三尖瓣心内膜炎手术预后的决定因素

Steinhoff, Jeffrey P; Kolli, Sahiti; Mattlin, Meredith P; Schlauch, Daniel; Braisted, Andrew T; Reddy, Sreenath V; Klodell, Charles; Dewey, Todd; Fontana, Gregory P

Inhibition of Casein Kinase 1 Alpha Prevents Acquired Drug Resistance to Erlotinib in EGFR-Mutant Non-Small Cell Lung Cancer

抑制酪蛋白激酶 1 Alpha 可预防 EGFR 突变型非小细胞肺癌患者对厄洛替尼产生获得性耐药性

Alexandra B Lantermann, Dongshu Chen, Kaitlin McCutcheon, Greg Hoffman, Elizabeth Frias, David Ruddy, Daniel Rakiec, Joshua Korn, Gregory McAllister, Frank Stegmeier, Matthew J Meyer, Sreenath V Sharma

A chemical biology approach to developing STAT inhibitors: molecular strategies for accelerating clinical translation

利用化学生物学方法开发STAT抑制剂:加速临床转化的分子策略

Nelson, Erik A; Sharma, Sreenath V; Settleman, Jeffrey; Frank, David A

Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe

靶向细胞周期蛋白E-Cdk-2复合物可通过触发后期灾难抑制肺癌生长

Galimberti, Fabrizio; Thompson, Sarah L; Liu, Xi; Li, Hua; Memoli, Vincent; Green, Simon R; DiRenzo, James; Greninger, Patricia; Sharma, Sreenath V; Settleman, Jeff; Compton, Duane A; Dmitrovsky, Ethan

A structure-guided approach to creating covalent FGFR inhibitors

一种基于结构的共价FGFR抑制剂构建方法

Zhou, Wenjun; Hur, Wooyoung; McDermott, Ultan; Dutt, Amit; Xian, Wa; Ficarro, Scott B; Zhang, Jianming; Sharma, Sreenath V; Brugge, Joan; Meyerson, Matthew; Settleman, Jeffrey; Gray, Nathanael S

Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.

利用高通量肿瘤细胞系分析鉴定与基因型相关的对选择性激酶抑制剂的敏感性

McDermott Ultan, Sharma Sreenath V, Dowell Lori, Greninger Patricia, Montagut Clara, Lamb Jennifer, Archibald Heidi, Raudales Raul, Tam Angela, Lee Diana, Rothenberg S Michael, Supko Jeffrey G, Sordella Raffaella, Ulkus Lindsey E, Iafrate A John, Maheswaran Shyamala, Njauw Ching Ni, Tsao Hensin, Drew Lisa, Hanke Jeff H, Ma Xiao-Jun, Erlander Mark G, Gray Nathanael S, Haber Daniel A, Settleman Jeffrey

A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes

Src、BCR-ABL 和 EGF 受体癌基因的“成瘾”可能源于共同的信号级联反应。

Sharma, Sreenath V; Gajowniczek, Patrycja; Way, Inna P; Lee, Diana Y; Jiang, Jane; Yuza, Yuki; Classon, Marie; Haber, Daniel A; Settleman, Jeffrey

Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib.

EGF 受体的不可逆抑制剂可以克服对吉非替尼的获得性耐药性

Kwak Eunice L, Sordella Raffaella, Bell Daphne W, Godin-Heymann Nadia, Okimoto Ross A, Brannigan Brian W, Harris Patricia L, Driscoll David R, Fidias Panos, Lynch Thomas J, Rabindran Sridhar K, McGinnis John P, Wissner Allan, Sharma Sreenath V, Isselbacher Kurt J, Settleman Jeffrey, Haber Daniel A