日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

脂化ApoE与受体相互作用的减少可保护机体免受溶酶体中ApoE及其脂质货物致病性的侵害。

Jing L Guo,Dylan Braun,Gabriel A Fitzgerald,Yun-Ting Hsieh,Lionel Rougé,Alexandra Litvinchuk,Micah Steffek,Nicholas E Propson,Catherine M Heffner,Claire Discenza,Suk Ji Han,Anil Rana,Lukas L Skuja,Bi Qi Lin,Elizabeth W Sun,Sonnet S Davis,Srijana Balasundar,Isabel Becerra,Jason C Dugas,Connie Ha,Jennifer Hsiao-Nakamoto,Fen Huang,Shourya Jain,Jennifer E Kung,Nicholas P D Liau,Cathal S Mahon,Hoang N Nguyen,Nathan Nguyen,Madhuja Samaddar,Yajuan Shi,David Tatarakis,Yuxi Tian,Yuda Zhu,Jung H Suh,Thomas Sandmann,Meredith E K Calvert,Annie Arguello,Lesley A Kane,Joseph W Lewcock,David M Holtzman,Christopher M Koth,Gilbert Di Paolo

Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding

优化一种新型DEL先导化合物,该化合物能与Cbl-b SH2结构域结合并阻断底物结合

Liang, Jun; Lambrecht, Michael J; Arenzana, Teresita L; Aubert-Nicol, Samuel; Bao, Linda; Broccatelli, Fabio; Cai, Jianping; Eidenschenk, Celine; Everett, Christine; Garner, Thomas; Gruber, Felix; Haghshenas, Pouyan; Huestis, Malcolm P; Hsu, Peter L; Kou, Ponien; Jakalian, Araz; Larouche-Gauthier, Robin; Leclerc, Jean-Philippe; Leung, Dennis H; Martin, Aaron; Murray, Jeremy; Prangley, Madeleine; Rutz, Sascha; Kakiuchi-Kiyota, Satoko; Satz, Alexander Lee; Skelton, Nicholas J; Steffek, Micah; Stoffler, Daniel; Sudhamsu, Jawahar; Tan, Sophia; Wang, Jian; Wang, Shouliang; Wang, Qiuyue; Wendorff, Timothy J; Wichert, Moreno; Yadav, Arun; Yu, Christine; Wang, Xiaojing

Severe multifocal coronary artery spasms after cessation of vasodilators in a patient with a spontaneous coronary artery dissection: a case report

自发性冠状动脉夹层患者停用血管扩张剂后出现严重多灶性冠状动脉痉挛:病例报告

Steffek, Zdenek; Kurz, David J; Bernheim, Alain M; Meyer, Matthias R

An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance

变构泛 TEAD 抑制剂阻断致癌 YAP/TAZ 信号传导并克服 KRAS G12C 抑制剂耐药性

Thijs J Hagenbeek #, Jason R Zbieg #, Marc Hafner #, Rana Mroue, Jennifer A Lacap, Nicole M Sodir, Cameron L Noland, Shervin Afghani, Ayush Kishore, Kamakoti P Bhat, Xiaosai Yao, Stephen Schmidt, Saundra Clausen, Micah Steffek, Wendy Lee, Paul Beroza, Scott Martin, Eva Lin, Rina Fong, Paola Di Lello

Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors

用于发现和表征 KRAS 抑制剂的构象锁定抗体

Christopher W Davies #, Angela J Oh #, Rana Mroue #, Micah Steffek #, John M Bruning, Yang Xiao, Siyu Feng, Sangeeta Jayakar, Emily Chan, Vidhyalakshmi Arumugam, Sean Carlo Uribe, Jake Drummond, Alexandra Frommlet, Cheng Lu, Yvonne Franke, Mark Merchant, Hartmut Koeppen, John G Quinn, Sushant Malhot

Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling

TEAD 脂化的小分子失调会诱导 Hippo 通路信号转导的显性负抑制

Jeffrey K Holden, James J Crawford, Cameron L Noland, Stephen Schmidt, Jason R Zbieg, Jennifer A Lacap, Richard Zang, Gregory M Miller, Yue Zhang, Paul Beroza, Rohit Reja, Wendy Lee, Jeffrey Y K Tom, Rina Fong, Micah Steffek, Saundra Clausen, Thjis J Hagenbeek, Taishan Hu, Zheng Zhou, Hong C Shen, C

Chemometrics-Assisted Identification of Anti-Inflammatory Compounds from the Green Alga Klebsormidium flaccidum var. zivo

化学计量学辅助鉴定绿藻 Klebsormidium flaccidum var. zivo 中的抗炎化合物

Shi Qiu, Shabana I Khan, Mei Wang, Jianping Zhao, Siyu Ren, Ikhlas A Khan, Amy Steffek, William P Pfund, Xing-Cong Li

Unlocking latent kinetic information from label-free binding

从无标记结合中解锁潜在动力学信息

John G Quinn, Micah Steffek, John M Bruning, Alexandra Frommlet, Melinda M Mulvihill

KALGAE™ (Klebsormidium flaccidum var. ZIVO) dried algal biomass - 90-day dietary toxicity study and genotoxicity studies

KALGAE™(Klebsormidium flaccidum var. ZIVO)干藻生物质 - 90 天饮食毒性研究和遗传毒性研究

Julie A Brickel, Ray A Matulka, Amy E Steffek

Molecular Basis of mRNA Cap Recognition by Influenza B Polymerase PB2 Subunit

流感B型聚合酶PB2亚基识别mRNA帽的分子基础

Xie, Lili; Wartchow, Charles; Shia, Steven; Uehara, Kyoko; Steffek, Micah; Warne, Robert; Sutton, James; Muiru, Gladys T; Leonard, Vincent H J; Bussiere, Dirksen E; Ma, Xiaolei