日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Reduced sialylation of airway mucin impairs mucus transport by altering the biophysical properties of mucin

呼吸道黏蛋白唾液酸化减少会改变黏蛋白的生物物理特性,从而损害黏液运输

Elex S Harris, Hannah J McIntire, Marina Mazur, Hinnerk Schulz-Hildebrandt, Hui Min Leung, Guillermo J Tearney, Stefanie Krick, Steven M Rowe #, Jarrod W Barnes #

Pulmonary Fibrosis Ferret Model Demonstrates Sustained Fibrosis, Restrictive Physiology, and Aberrant Repair

肺纤维化雪貂模型表现出持续性纤维化、限制性生理和异常修复

Jacelyn E Peabody Lever, Qian Li, Nikoleta Pavelkova, Shah S Hussain, Sayan Bakshi, Janna Q Ren, Luke I Jones, Jared Kennemur, Mason Weupe, Javier Campos-Gomez, Liping Tang, Jeremie M P Lever, Dezhi Wang, Denise D Stanford, Jeremy Foote, Kevin S Harrod, Harrison Kim, Scott E Phillips, Steven M Rowe

Reduced Sialylation of Airway Mucin Impairs Mucus Transport by Altering the Biophysical Properties of Mucin

气道黏蛋白唾液酸化降低会改变黏蛋白的生物物理性质,从而损害黏液运输

Elex S Harris, Hannah J McIntire, Marina Mazur, Hinnerk Schulz-Hildebrandt, Hui Min Leung, Guillermo J Tearney, Stefanie Krick, Steven M Rowe, Jarrod W Barnes

Extracellular vesicles enhance pulmonary transduction of stably associated adeno-associated virus following intratracheal administration

气管内给药后,细胞外囊泡可增强稳定结合的腺相关病毒在肺部的转导作用。

Gijung Kwak ,Olesia Gololobova ,Neeraj Sharma ,Colin Caine ,Marina Mazur ,Kathleen Mulka ,Natalie E West ,George M Solomon ,Garry R Cutting ,Kenneth W Witwer ,Steven M Rowe ,Michael Paulaitis ,George Aslanidi ,Jung Soo Suk

Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist

药物改善 CFTR 功能可迅速降低痰液病原体密度,但肺部感染通常会持续存在

David P Nichols, Sarah J Morgan, Michelle Skalland, Anh T Vo, Jill M Van Dalfsen, Sachinkumar Bp Singh, Wendy Ni, Lucas R Hoffman, Kailee McGeer, Sonya L Heltshe, John P Clancy, Steven M Rowe, Peter Jorth, Pradeep K Singh; PROMISE-Micro Study Group

The synthetic aminoglycoside ELX-02 induces readthrough of G550X-CFTR producing superfunctional protein that can be further enhanced by CFTR modulators

合成氨基糖苷 ELX-02 可诱导 G550X-CFTR 读通,产生超功能蛋白质,而 CFTR 调节剂可进一步增强该蛋白质的功能

Jianguo Chen, Kari Thrasher, Lianwu Fu, Wei Wang, Soheil Aghamohammadzadeh, Hui Wen, Liping Tang, Kim M Keeling, Emily Falk Libby, David M Bedwell, Steven M Rowe

Mucociliary clearance augmenting drugs block SARS-CoV-2 replication in human airway epithelial cells

增强粘膜纤毛清除的药物可阻断 SARS-CoV-2 在人类呼吸道上皮细胞中的复制

Javier Campos-Gómez, Courtney Fernandez Petty, Marina Mazur, Liping Tang, George M Solomon, Reny Joseph, Qian Li, Jacelyn E Peabody Lever, Shah Saddad Hussain, Kevin S Harrod, Ezinwanne E Onuoha, Harrison Kim, Steven M Rowe

Prime editing-mediated correction of the CFTR W1282X mutation in iPSCs and derived airway epithelial cells

通过 Prime 编辑介导纠正 iPSC 和衍生的气道上皮细胞中的 CFTR W1282X 突变

Chao Li, Zhong Liu, Justin Anderson, Zhongyu Liu, Liping Tang, Yao Li, Ning Peng, Jianguo Chen, Xueming Liu, Lianwu Fu, Tim M Townes, Steven M Rowe, David M Bedwell, Jennifer Guimbellot, Rui Zhao

An ex vivo rat trachea model reveals abnormal airway physiology and a gland secretion defect in cystic fibrosis

离体大鼠气管模型揭示囊性纤维化中的气道生理异常和腺体分泌缺陷

Elex Harris, Molly Easter, Janna Ren, Stefanie Krick, Jarrod Barnes, Steven M Rowe

Triamterene Functions as an Effective Nonsense Suppression Agent for MPS I-H (Hurler Syndrome)

氨苯蝶啶是治疗 MPS IH(Hurler 综合征)的有效无意义抑制剂

Amna Siddiqui, Halil Dundar, Jyoti Sharma, Aneta Kaczmarczyk, Josh Echols, Yanying Dai, Chuanxi Richard Sun, Ming Du, Zhong Liu, Rui Zhao, Tim Wood, Shalisa Sanders, Lynn Rasmussen, James Robert Bostwick, Corinne Augelli-Szafran, Mark Suto, Steven M Rowe, David M Bedwell, Kim M Keeling