日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

De novo design of a peptide modulator to reverse sodium channel dysfunction linked to cardiac arrhythmias and epilepsy

从头设计一种肽调节剂,以逆转与心律失常和癫痫相关的钠通道功能障碍

Ryan Mahling ,Bence Hegyi ,Erin R Cullen ,Timothy M Cho ,Aaron R Rodriques ,Lucile Fossier ,Marc Yehya ,Lin Yang ,Bi-Xing Chen ,Alexander N Katchman ,Nourdine Chakouri ,Ruiping Ji ,Elaine Y Wan ,Jared Kushner ,Steven O Marx ,Sergey Ovchinnikov ,Christopher D Makinson ,Donald M Bers ,Manu Ben-Johny

Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome

多种不依赖β细胞的机制导致蒂莫西综合征患者发生低血糖

Maiko Matsui, Lauren E Lynch, Isabella Distefano, Allison Galante, Aravind R Gade, Hong-Gang Wang, Nicolas Gómez-Banoy, Patrick Towers, Daniel S Sinden, Eric Q Wei, Adam S Barnett, Kenneth Johnson, Renan Lima, Alfonso Rubio-Navarro, Ang K Li, Steven O Marx, Timothy E McGraw, Paul S Thornton, Katheri

Engineered cardiac tissue model of restrictive cardiomyopathy for drug discovery

用于药物研发的限制性心肌病工程化心脏组织模型

Bryan Z Wang ,Trevor R Nash ,Xiaokan Zhang ,Jenny Rao ,Laura Abriola ,Youngbin Kim ,Sergey Zakharov ,Michael Kim ,Lori J Luo ,Margaretha Morsink ,Bohao Liu ,Roberta I Lock ,Sharon Fleischer ,Manuel A Tamargo ,Michael Bohnen ,Carrie L Welch ,Wendy K Chung ,Steven O Marx ,Yulia V Surovtseva ,Gordana Vunjak-Novakovic ,Barry M Fine

Effect of mechanical unloading on genome-wide DNA methylation profile of the failing human heart

机械卸载对人类心脏衰竭全基因组 DNA 甲基化谱的影响

Xianghai Liao, Peter J Kennel, Bohao Liu, Trevor R Nash, Richard Z Zhuang, Amandine F Godier-Furnemont, Chenyi Xue, Rong Lu, Paolo C Colombo, Nir Uriel, Muredach P Reilly, Steven O Marx, Gordana Vunjak-Novakovic, Veli K Topkara

Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current

成纤维细胞生长因子同源因子作为调节心律失常性心脏晚钠电流的分子变阻器

Nourdine Chakouri, Sharen Rivas, Daniel Roybal, Lin Yang, Johanna Diaz, Allen Hsu, Ryan Mahling, Bi-Xing Chen, Josiah O Owoyemi, Deborah DiSilvestre, Dario Sirabella, Barbara Corneo, Gordon F Tomaselli, Ivy E Dick, Steven O Marx, Manu Ben-Johny

Increased Ca2+ influx through CaV1.2 drives aortic valve calcification

通过 CaV1.2 增加 Ca2+ 流入会导致主动脉瓣钙化

Maiko Matsui, Rihab Bouchareb, Mara Storto, Yasin Hussain, Andrew Gregg, Steven O Marx, Geoffrey S Pitt

Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics

邻近蛋白质组学揭示肾上腺素能 CaV1.2 刺激的机制

Guoxia Liu #, Arianne Papa #, Alexander N Katchman #, Sergey I Zakharov #, Daniel Roybal, Jessica A Hennessey, Jared Kushner, Lin Yang, Bi-Xing Chen, Alexander Kushnir, Katerina Dangas, Steven P Gygi, Geoffrey S Pitt, Henry M Colecraft, Manu Ben-Johny, Marian Kalocsay, Steven O Marx

Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels

成纤维细胞生长因子同源因子调节钙调蛋白结合缺陷通道中致心律失常的晚期 NaV1.5 电流

Jeffrey Abrams, Daniel Roybal, Nourdine Chakouri, Alexander N Katchman, Richard Weinberg, Lin Yang, Bi-Xing Chen, Sergey I Zakharov, Jessica A Hennessey, Uma Mahesh R Avula, Johanna Diaz, Chaojian Wang, Elaine Y Wan, Geoffrey S Pitt, Manu Ben-Johny, Steven O Marx

Heterogeneity of the action potential duration is required for sustained atrial fibrillation

持续性心房颤动需要动作电位持续时间的异质性

Uma Mahesh R Avula, Jeffrey Abrams, Alexander Katchman, Sergey Zakharov, Sergey Mironov, Joseph Bayne, Daniel Roybal, Anirudh Gorti, Lin Yang, Vivek Iyer, Marc Waase, Deepak Saluja, Edward J Ciaccio, Hasan Garan, Andrew R Marks, Steven O Marx, Elaine Y Wan

Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice

异常钠流入导致小鼠心肌病和心房颤动

Elaine Wan, Jeffrey Abrams, Richard L Weinberg, Alexander N Katchman, Joseph Bayne, Sergey I Zakharov, Lin Yang, John P Morrow, Hasan Garan, Steven O Marx