Strebhardt相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high-grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical models

在临床前模型中，通过mRNA脂质体靶向激活新型肿瘤抑制因子DAPK1（p53的上游调节因子）可降低高级别浆液性卵巢癌的细胞活力并增强药物敏感性。

期刊:Cancer Communications

影响因子:24.9

doi:10.1002/cac2.70029

Raab, Monika; Győrffy, Balázs; Peña-Llopis, Samuel; Fietz, Daniela; Kressin, Monika; Kolaric, Margareta; Ebert, Matthias; Gasimli, Khayal; Becker, Sven; Sanhaji, Mourad; Strebhardt, Klaus

细胞生物学

发表日期：2025

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Structural regulation of PLK1 activity: implications for cell cycle function and drug discovery

PLK1活性的结构调控：对细胞周期功能和药物发现的意义

期刊:Cancer Gene Therapy

doi:10.1038/s41417-025-00907-7

Chapagai, Danda; Strebhardt, Klaus; Wyatt, Michael D; McInnes, Campbell

细胞生物学

发表日期：2025

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Truncated DAPK Variants Restore Tumor Suppressor Activity and Synergize with Standard Therapies in High-Grade Serous Ovarian Cancer.

截短的 DAPK 变体可恢复肿瘤抑制活性，并与高级别浆液性卵巢癌的标准疗法产生协同作用

影响因子:4.4

doi:10.3390/cancers17121910

Raab Monika, Gasimli Khayal, GyÅrffy BalÃ¡zs, PeÃ±a-Llopis Samuel, Becker Sven, Sanhaji Mourad, Strebhardt Klaus

发表日期：2025

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Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancer

体外转录 mRNA 挽救 p53 功能可抑制高级别浆液性卵巢癌的生长

期刊:Cancer Communications

doi:10.1002/cac2.12511

Monika Raab, Izabela Kostova, Samuel Peña-Llopis, Daniela Fietz, Monika Kressin, Seyed Mohsen Aberoumandi, Evelyn Ullrich, Sven Becker, Mourad Sanhaji, Klaus Strebhardt

发表日期：2024

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Correction: A dimerization-dependent mechanism regulates enzymatic activation and nuclear entry of PLK1

更正：PLK1 的酶活性激活和核转位受二聚化依赖机制调控。

期刊:Oncogene

影响因子:7.3

doi:10.1038/s41388-023-02779-3

Raab, Monika; Matthess, Yves; Raab, Christopher A; Gutfreund, Niklas; Dötsch, Volker; Becker, Sven; Sanhaji, Mourad; Strebhardt, Klaus

发表日期：2023

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Correction: The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancer

更正：Caspase-8 在宫颈癌中负调控 CDK9 介导的 RNA 聚合酶 II Ser2 磷酸化的非凋亡功能

期刊:Cellular and Molecular Life Sciences

影响因子:6.2

doi:10.1007/s00018-023-04686-y

Mandal, Ranadip; Raab, Monika; Rödel, Franz; Krämer, Andrea; Kostova, Izabela; Peña-Llopis, Samuel; Medici, Gioele; Häupl, Björn; Oellerich, Thomas; Gasimli, Khayal; Sanhaji, Mourad; Becker, Sven; Strebhardt, Klaus

发表日期：2023

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Synergistic Sensitization of High-Grade Serous Ovarian Cancer Cells Lacking Caspase-8 Expression to Chemotherapeutics Using Combinations of Small-Molecule BRD4 and CDK9 Inhibitors

利用小分子BRD4和CDK9抑制剂的组合对缺乏Caspase-8表达的高级别浆液性卵巢癌细胞的化疗药物产生协同增敏作用

影响因子:4.4

doi:10.3390/cancers16010107

Gasimli, Khayal; Raab, Monika; Mandal, Ranadip; Krämer, Andrea; Peña-Llopis, Samuel; Tahmasbi Rad, Morva; Becker, Sven; Strebhardt, Klaus; Sanhaji, Mourad

细胞生物学

发表日期：2023

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A dimerization-dependent mechanism regulates enzymatic activation and nuclear entry of PLK1

二聚化依赖机制调节PLK1的酶活化和核进入

期刊:Oncogene

影响因子:6.9

doi:10.1038/s41388-021-02094-9

Monika Raab, Yves Matthess, Christopher A Raab, Niklas Gutfreund, Volker Dötsch, Sven Becker, Mourad Sanhaji #, Klaus Strebhardt #

发表日期：2022

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The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancer

Caspase-8在宫颈癌中负向调控CDK9介导的RNA聚合酶II Ser2磷酸化的非凋亡作用

期刊:Cellular and Molecular Life Sciences

影响因子:6.2

doi:10.1007/s00018-022-04598-3

Ranadip Mandal, Monika Raab, Franz Rödel, Andrea Krämer, Izabela Kostova, Samuel Peña-Llopis, Björn Häupl, Thomas Oellerich, Khayal Gasimli, Mourad Sanhaji, Sven Becker, Klaus Strebhardt

发表日期：2022

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The Role of DAPK1 in the Cell Cycle Regulation of Cervical Cancer Cells and in Response to Topotecan

DAPK1 在宫颈癌细胞细胞周期调控和对拓扑替康的反应中的作用

期刊:Journal of Cancer

影响因子:3.3

doi:10.7150/jca.66492

Khayal Gasimli, Monika Raab, Sven Becker, Mourad Sanhaji, Klaus Strebhardt

IgG light chain

发表日期：2022

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