日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BICC1 interacts with PKD1 and PKD2 to drive cystogenesis in ADPKD

BICC1 与 PKD1 和 PKD2 相互作用,驱动 ADPKD 中的囊肿形成。

Tran, Uyen; Streets, Andrew J; Smith, Devon; Decker, Eva; Kirschfink, Annemarie; Izem, Lahoucine; Hassey, Jessie M; Rutland, Briana; Valluru, Manoj K; Bräsen, Jan Hinrich; Ott, Elisabeth; Epting, Daniel; Eisenberger, Tobias; Ong, Albert C M; Bergmann, Carsten; Wessely, Oliver

Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies.

药物和siRNA筛选确定ROCK2是纤毛病的一种治疗靶点

Smith Claire E L, Streets Andrew J, Lake Alice V R, Natarajan Subaashini, Best Sunayna K, Szymanska Katarzyna, Karwatka Magdalena, Stevenson Thomas, Trowbridge Rachel, Grant Gary, Grellscheid Sushma N, Foster Richard, Morrison Ciaran G, Mavria Georgia, Bond Jacquelyn, Ong Albert C M, Johnson Colin A

The association of urinary epidermal growth factors with ADPKD disease severity and progression.

尿表皮生长因子与 ADPKD 疾病严重程度和进展的关系

Harskamp Laura R, Perez-Gomez Maria Vanessa, Heida Judith E, Engels Gerwin E, van Goor Harry, van den Heuvel Marius C, Streets Andrew J, Ong Albert C M, Ortiz Alberto, Gansevoort Ron T

Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation

疾病中多囊蛋白-2在关键残基上的过度磷酸化揭示了多囊蛋白-1调控的去磷酸化作用的重要作用

Streets, Andrew J; Wessely, Oliver; Peters, Dorien J M; Ong, Albert C M

Thiazolidinediones inhibit MDCK cyst growth through disrupting oriented cell division and apicobasal polarity

噻唑烷二酮类药物通过破坏定向细胞分裂和顶底极性来抑制MDCK囊肿生长。

Mao, Zhiguo; Streets, Andrew J; Ong, Albert C M

Protein kinase D-mediated phosphorylation of polycystin-2 (TRPP2) is essential for its effects on cell growth and calcium channel activity

蛋白激酶D介导的多囊蛋白-2 (TRPP2) 磷酸化对其影响细胞生长和钙通道活性至关重要。

Streets, Andrew J; Needham, Andrew J; Gill, Sharonjit K; Ong, Albert C M

Homophilic and heterophilic polycystin 1 interactions regulate E-cadherin recruitment and junction assembly in MDCK cells

同嗜性和异嗜性多囊蛋白1相互作用调控MDCK细胞中E-钙黏蛋白的募集和连接组装。

Streets, Andrew J; Wagner, Bart E; Harris, Peter C; Ward, Christopher J; Ong, Albert C M

Activation of TRPP2 through mDia1-dependent voltage gating

通过 mDia1 依赖性电压门控激活 TRPP2

Bai, Chang-Xi; Kim, Sehyun; Li, Wei-Ping; Streets, Andrew J; Ong, Albert C M; Tsiokas, Leonidas