日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies.

药物和siRNA筛选确定ROCK2是纤毛病的一种治疗靶点

Smith Claire E L, Streets Andrew J, Lake Alice V R, Natarajan Subaashini, Best Sunayna K, Szymanska Katarzyna, Karwatka Magdalena, Stevenson Thomas, Trowbridge Rachel, Grant Gary, Grellscheid Sushma N, Foster Richard, Morrison Ciaran G, Mavria Georgia, Bond Jacquelyn, Ong Albert C M, Johnson Colin A

The ATOM-Seq sequence capture panel can accurately predict microsatellite instability status in formalin-fixed tumour samples, alongside routine gene mutation testing

ATOM-Seq序列捕获试剂盒能够准确预测福尔马林固定肿瘤样本中的微卫星不稳定性状态,并可与常规基因突变检测相结合。

Srihar, Kanishta; Gusnanto, Arief; Richman, Susan D; West, Nicholas P; Galvin, Leanne; Bottomley, Daniel; Hemmings, Gemma; Glover, Amy; Natarajan, Subaashini; Miller, Rebecca; Arif, Sameira; Rossington, Hannah; Dunwell, Thomas L; Dailey, Simon C; Fontarum, Gracielle; George, Agnes; Wu, Winnie; Quirke, Phil; Wood, Henry M

The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5

纤毛Frizzled样受体Tmem67通过Hoxb5调节发育中小脑的经典Wnt/β-catenin信号通路。

Abdelhamed, Zakia A; Abdelmottaleb, Dina I; El-Asrag, Mohammed E; Natarajan, Subaashini; Wheway, Gabrielle; Inglehearn, Chris F; Toomes, Carmel; Johnson, Colin A

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes

基于 siRNA 的功能基因组学筛选,用于鉴定纤毛发生和纤毛病基因的调节剂

Gabrielle Wheway #, Miriam Schmidts #, Dorus A Mans #, Katarzyna Szymanska #, Thanh-Minh T Nguyen #, Hilary Racher, Ian G Phelps, Grischa Toedt, Julie Kennedy, Kirsten A Wunderlich, Nasrin Sorusch, Zakia A Abdelhamed, Subaashini Natarajan, Warren Herridge, Jeroen van Reeuwijk, Nicola Horn, Karsten B

The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway

梅克尔-格鲁伯综合征蛋白 TMEM67 通过非经典 Wnt 通路控制小鼠的基底体定位和上皮分支形态发生

Zakia A Abdelhamed, Subaashini Natarajan, Gabrielle Wheway, Christopher F Inglehearn, Carmel Toomes, Colin A Johnson, Daniel J Jagger

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

MICU1 的功能丧失突变会导致大脑和肌肉疾病,这与线粒体钙信号的原发性改变有关

Clare V Logan, György Szabadkai, Jenny A Sharpe, David A Parry, Silvia Torelli, Anne-Marie Childs, Marjolein Kriek, Rahul Phadke, Colin A Johnson, Nicola Y Roberts, David T Bonthron, Karen A Pysden, Tamieka Whyte, Iulia Munteanu, A Reghan Foley, Gabrielle Wheway, Katarzyna Szymanska, Subaashini Nata

Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel-Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and Wnt signalling defects

包括梅克尔-格鲁伯综合征和乔伯特综合征在内的纤毛病神经表型的可变表现是由复杂的失调纤毛发生、Shh 和 Wnt 信号传导缺陷引起的

Zakia A Abdelhamed, Gabrielle Wheway, Katarzyna Szymanska, Subaashini Natarajan, Carmel Toomes, Chris Inglehearn, Colin A Johnson

HEXIM1 induces differentiation of human pluripotent stem cells

HEXIM1诱导人类多能干细胞分化

Ding, Vanessa; Lew, Qiao Jing; Chu, Kai Ling; Natarajan, Subaashini; Rajasegaran, Vikneswari; Gurumurthy, Meera; Choo, Andre B H; Chao, Sheng-Hao

Tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells

FGF-2 刺激的人类胚胎干细胞中的酪氨酸磷酸化分析

Vanessa M Y Ding, Paul J Boersema, Leong Yan Foong, Christian Preisinger, Geoffrey Koh, Subaashini Natarajan, Dong-Yup Lee, Jos Boekhorst, Berend Snel, Simone Lemeer, Albert J R Heck, Andre Choo