日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Auranofin, identified by FDA-approved drug library screening, inhibits HBs antigen secretion via lysosomal damage

金诺芬（Auranofin）是通过FDA批准的药物库筛选发现的，它通过溶酶体损伤抑制HBs抗原的分泌。

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0340023
Shimoda, Akiyoshi; Murai, Kazuhiro; Hikita, Hayato; Minami, Satoshi; Miyake, Takayuki; Kuriki, Shinji; Sometani, Emi; Sung, Jihyun; Shigeno, Satoshi; Higuchi, Yuichiro; Maesaka, Kazuki; Shirai, Kumiko; Tahata, Yuki; Saito, Yoshinobu; Kodama, Takahiro; Takahashi, Takeshi; Suemizu, Hiroshi; Takehara, Tetsuo
发表日期：2026
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Correction: Development of a DNA damage assay system using stable human hepatocytes

更正：利用稳定人肝细胞开发DNA损伤检测系统

期刊:Genes and Environment
影响因子:1.9
doi:10.1186/s41021-026-00355-1
Mishima, Masayuki; Izawa, Kazuki; Tsuda, Masataka; Higuchi, Yuichiro; Uehara, Shotaro; Suemizu, Hiroshi; Sugiyama, Kei-Ichi
细胞生物学
毒理研究
发表日期：2026
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Development of a DNA damage assay system using stable human hepatocytes.

利用稳定的人类肝细胞开发DNA损伤检测系统。

期刊:Genes and Environment
影响因子:1.9
doi:10.1186/s41021-025-00347-7
Mishima Masayuki, Izawa Kazuki, Tsuda Masataka, Higuchi Yuichiro, Uehara Shotaro, Suemizu Hiroshi, Sugiyama Kei-Ichi
Human
细胞生物学
发表日期：2026
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Systemic Identification of Functionally Conserved Long Noncoding RNA Metabolic Regulators in Human and Mouse Livers

系统性鉴定人和小鼠肝脏中功能保守的长链非编码RNA代谢调节因子

期刊:Gastroenterology
影响因子:25.7
doi:10.1053/j.gastro.2025.03.015
Chengfei Jiang ,Zhe Li ,Sunmi Seok ,Ping Li ,Yonghe Ma ,Stephanie K Podguski ,Shria Moturi ,Nao Yoneda ,Kenji Kawai ,Shotaro Uehara ,Yasuyuki Ohnishi ,Hiroshi Suemizu ,Jinwei Zhang ,Haiming Cao
Human
Mouse
代谢
发表日期：2025
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Netrin-1 inhibits the attachment and internalization of Hepatitis B virus for hepatocyte infection

Netrin-1抑制乙型肝炎病毒附着和内化，从而抑制肝细胞感染。

期刊:PLoS Pathogens
影响因子:5.5
doi:10.1371/journal.ppat.1013776.
Ying Wang,Kazuhisa Murai,Atsuya Ishida,Narumi Kawasaki,Kazuyuki Kuroki,Ying-Yi Li,Yuga Sato,Yutaro Miura,Kureha Takara,Lianghao Kong,Tetsuro Shimakami,Kouki Nio,Yuichiro Higuchi,Hiroshi Suemizu,Satoru Ito,Hiroshi Yanagawa,Shuichi Kaneko,Taro Yamashita,Masao Honda
肝炎
细胞生物学
炎症/感染
毒理研究
发表日期：2025
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Chromatin remodeler BRD9 represses transcription of PPARα target genes, including CPT1A to suppress lipid metabolism

染色质重塑因子BRD9抑制PPARα靶基因（包括CPT1A）的转录，从而抑制脂质代谢。

期刊:Journal of Lipid Research
影响因子:4.1
doi:10.1016/j.jlr.2025.100874
Yokoseki, Itsuki; Nakano, Masataka; Kurosawa, Kiamu; Higuchi, Yuichiro; Uehara, Shotaro; Yoneda, Nao; Suemizu, Hiroshi; Fukami, Tatsuki; Nakajima, Miki
染色质重塑
表观遗传
BRD9
代谢
发表日期：2025
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Alcohol dehydrogenase 4 and aldo-keto reductase 1A1 catalyze the oxidation of 4-hydroxytolbutamide, a metabolite of tolbutamide, in the human liver

在人肝脏中，醇脱氢酶4和醛酮还原酶1A1催化4-羟基甲苯磺丁脲（甲苯磺丁脲的代谢产物）的氧化。

期刊:Drug Metabolism and Disposition
影响因子:4
doi:10.1016/j.dmd.2025.100173
Shimomura, Kazuya; Sato, Rei; Watanabe, Miyu; Higuchi, Yuichiro; Uehara, Shotaro; Yoneda, Nao; Nakano, Masataka; Suemizu, Hiroshi; Nakajima, Miki; Fukami, Tatsuki
代谢
发表日期：2025
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In Vitro Assessment of Drug-Induced Liver Injury Using Three-Dimensional Cultured HepaSH Cells Derived From Chimeric Mouse Model With Humanized Liver

利用源自人源化肝脏嵌合小鼠模型的三维培养HepaSH细胞进行药物诱导肝损伤的体外评估

期刊:Journal of Applied Toxicology
影响因子:2.8
doi:10.1002/jat.4863
Liu, Xingming; Higuchi, Yuichiro; Sakamoto, Yuta; Yanagida, Shota; Uehara, Shotaro; Suemizu, Hiroshi; Kanda, Yasunari; Kawagishi, Hiroyuki
Human
Mouse
发表日期：2025
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Metabolism and effects of acetoaceto-o-toluidine in the urinary bladder of humanized-liver mice

乙酰乙酰邻甲苯胺在人源化肝小鼠膀胱中的代谢和作用

期刊:Journal of Toxicologic Pathology
影响因子:0.9
doi:10.1293/tox.2024-0042
Suzuki, Shugo; Gi, Min; Yanagiba, Yukie; Yoneda, Nao; Uehara, Shotaro; Yokota, Yuka; Noura, Ikue; Fujioka, Masaki; Vachiraarunwong, Arpamas; Kakehashi, Anna; Koda, Shigeki; Suemizu, Hiroshi; Wanibuchi, Hideki
代谢
发表日期：2025
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Comprehensive gene profiling of the metabolic landscape of humanized livers in mice.

对小鼠人源化肝脏的代谢图谱进行全面的基因分析

期刊:Journal of Hepatology
影响因子:33
doi:10.1016/j.jhep.2023.11.020
Jiang Chengfei, Li Ping, Ma Yonghe, Yoneda Nao, Kawai Kenji, Uehara Shotaro, Ohnishi Yasuyuki, Suemizu Hiroshi, Cao Haiming
代谢
发表日期：2024
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