日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A proteogenomic gene signature defines prognostic subgroups highlighting PI3K/AKT/mTOR signaling pathway as a therapeutic vulnerability in myeloid malignancies

蛋白质基因组学特征定义了预后亚组,突显了PI3K/AKT/mTOR信号通路在髓系恶性肿瘤治疗中的脆弱性。

He, Fan; Lin, Shuyang; Gao, Bei; Ramesh, Varun; Kim, Alexander B; Kong, Tim; Fisher, Daniel A C; Letson, Christopher T; Brakhane, Molly; Fulbright, Mary; Yu, Yanbo; Sardiello, Marco; Di Paola, Jorge; Sykes, Stephen M; Oh, Stephen T

Dominant negative ATP5F1A variants disrupt oxidative phosphorylation causing neurological disorders.

显性负性 ATP5F1A 变体破坏氧化磷酸化,导致神经系统疾病

Fielder Sara M, Friederich Marisa W, Hock Daniella H, Zhang Jessie R, Valin Liana M, Rosenfeld Jill A, Booth Kevin T A, Brown Natasha J, Rius Rocio, Sharma Tanavi, Semcesen Liana N, Worley Kim C, Burrage Lindsay C, Treat Kayla, Samson Tara, Govert Sarah, DaCunha Sara, Yuan Weimin, Chen Jian, Lesinski Jacob, Hoang Hieu, Morrison Stephanie A, Ladha Farah A, Van Hove Roxanne A, Michel Cole R, Reisdorph Richard, Tycksen Eric, Baldridge Dustin, Silverman Gary A, Soler-Alfonso Claudia, Conboy Erin, Vetrini Francesco, Emrick Lisa, Craigen William J, Sykes Stephen M, Stroud David A, Van Hove Johan L K, Schedl Tim, Pak Stephen C

Missense mutations in Myc Box I influence MYC cellular localization, mRNA partitioning and turnover to promote leukemogenesis

Myc Box I 中的错义突变会影响 MYC 的细胞定位、mRNA 分配和周转,从而促进白血病发生。

Arthur, Nancy Bj; Christensen, Keegan A; Mannino, Kathleen; Ruzinova, Marianna B; Kumar, Ashutosh; Gruszczynska, Agata; Day, Ryan B; Erdmann-Gilmore, Petra; Mi, Yiling; Sprung, Robert; York, Conner R; Reid Townsend, R; Spencer, David H; Sykes, Stephen M; Ferraro, Francesca

The -2518 A/G polymorphism of the monocyte chemoattractant protein-1 as a candidate genetic predisposition factor for secondary myelofibrosis and biomarker of disease severity

单核细胞趋化蛋白-1的-2518 A/G多态性作为继发性骨髓纤维化的候选遗传易感因素和疾病严重程度的生物标志物

Masselli, Elena; Carubbi, Cecilia; Cambò, Benedetta; Pozzi, Giulia; Gobbi, Giuliana; Mirandola, Prisco; Follini, Elena; Pagliaro, Luca; Di Marcantonio, Daniela; Bonatti, Francesco; Percesepe, Antonio; Sykes, Stephen M; Aversa, Franco; Vitale, Marco

Clonal evolution of preleukemic hematopoietic stem cells in acute myeloid leukemia

急性髓系白血病中白血病前造血干细胞的克隆演变

Sykes, Stephen M; Kokkaliaris, Konstantinos D; Milsom, Michael D; Levine, Ross L; Majeti, Ravindra

Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors

造血祖细胞中RICTOR/mTORC2的跨膜抑制剂

Lee, Dongjun; Sykes, Stephen M; Kalaitzidis, Demetrios; Lane, Andrew A; Kfoury, Youmna; Raaijmakers, Marc H G P; Wang, Ying-Hua; Armstrong, Scott A; Scadden, David T

Modeling human hematopoietic stem cell biology in the mouse

在小鼠中模拟人类造血干细胞生物学

Sykes, Stephen M; Scadden, David T

Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53

p53通过调控DNA结合域的乙酰化来调节转录非依赖性细胞凋亡

Sykes, Stephen M; Stanek, Timothy J; Frank, Amanda; Murphy, Maureen E; McMahon, Steven B

Menin induces apoptosis in murine embryonic fibroblasts

Menin诱导小鼠胚胎成纤维细胞凋亡

Schnepp, Robert W; Mao, Hua; Sykes, Stephen M; Zong, Wei-Xing; Silva, Albert; La, Ping; Hua, Xianxin