日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Neuroprotection by chronic administration of Fluoroethylnormemantine (FENM) in mouse models of Alzheimer's disease

长期服用氟乙基去甲美金刚胺 (FENM) 对阿尔茨海默病小鼠模型具有神经保护作用

Allison Carles, Aline Freyssin, Sarra Guehairia, Thomas Reguero, Michel Vignes, Hélène Hirbec, Gilles Rubinstenn, Tangui Maurice

The Wolfram-like variant WFS1E864K destabilizes MAM and compromises autophagy and mitophagy in human and mice

Wolfram 样变体 WFS1E864K 会破坏 MAM 的稳定性,并损害人和小鼠的自噬和线粒体自噬。

Simone Patergnani ,Méghane S Bataillard ,Alberto Danese ,Stacy Alves ,Chantal Cazevieille ,René Valéro ,Lisbeth Tranebjærg ,Tangui Maurice ,Paolo Pinton ,Benjamin Delprat ,Elodie M Richard

The selective butyrylcholinesterase inhibitor UW-MD-95 shows symptomatic and neuroprotective effects in a pharmacological mouse model of Alzheimer's disease

选择性丁酰胆碱酯酶抑制剂 UW-MD-95 在阿尔茨海默病的药理小鼠模型中表现出对症和神经保护作用

Allison Carles, Matthias Hoffmann, Matthias Scheiner, Lucie Crouzier, Christelle Bertrand-Gaday, Arnaud Chatonnet, Michael Decker, Tangui Maurice

Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine

核孔蛋白 POM121 通过普利多比定激活 SIGMAR1/sigma-1 受体分子伴侣,发出 TFEB 介导的自噬信号

Shao-Ming Wang, Hsiang-En Wu, Yuko Yasui, Michal Geva, Michael Hayden, Tangui Maurice, Mauro Cozzolino, Tsung-Ping Su

Wfs1E864K knock-in mice illuminate the fundamental role of Wfs1 in endocochlear potential production

Wfs1E864K敲入小鼠揭示了Wfs1在内耳电位产生中的基础作用。

Elodie M Richard # ,Emilie Brun # ,Julia Korchagina ,Lucie Crouzier ,Corentin Affortit ,Stacy Alves ,Chantal Cazevieille ,Anne-Laure Mausset-Bonnefont ,Marc Lenoir ,Jean-Luc Puel ,Tangui Maurice ,Marc Thiry ,Jing Wang ,Benjamin Delprat

Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model

双重作用的小分子:亚型选择性大麻素受体 2 激动剂/丁酰胆碱酯酶抑制剂混合物在阿尔茨海默病小鼠模型中表现出神经保护作用

Philipp Spatz, Sophie A M Steinmüller, Anna Tutov, Eleonora Poeta, Axelle Morilleau, Allison Carles, Marie H Deventer, Julian Hofmann, Christophe P Stove, Barbara Monti, Tangui Maurice, Michael Decker

Microglial P2X4 receptors promote ApoE degradation and contribute to memory deficits in Alzheimer's disease

小胶质细胞 P2X4 受体促进 ApoE 降解并导致阿尔茨海默病的记忆缺陷

Jennifer Hua, Elvira Garcia de Paco, Nathalie Linck, Tangui Maurice, Catherine Desrumaux, Bénédicte Manoury, François Rassendren #, Lauriane Ulmann #

Activation of the sigma-1 receptor chaperone alleviates symptoms of Wolfram syndrome in preclinical models

sigma-1 受体伴侣的激活可缓解临床前模型中的 Wolfram 综合征症状

Lucie Crouzier, Alberto Danese, Yuko Yasui, Elodie M Richard, Jean-Charles Liévens, Simone Patergnani, Simon Couly, Camille Diez, Morgane Denus, Nicolas Cubedo, Mireille Rossel, Marc Thiry, Tsung-Ping Su, Paolo Pinton, Tangui Maurice, Benjamin Delprat

Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling

Sigma-1 受体激动剂 PRE-084 通过 NRF2 信号传导保护机体免受 TAR DNA 结合蛋白 43 毒性的影响

Christelle Lasbleiz, Amandine Peyrel, Pauline Tarot, Jérôme Sarniguet, Lucie Crouzier, Nicolas Cubedo, Benjamin Delprat, Mireille Rossel, Tangui Maurice, Jean-Charles Liévens

Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines

形态学、行为学和细胞分析揭示了 Wolfram 综合征 wfs1a 和 wfs1b 斑马鱼突变系的不同表型

Lucie Crouzier, Elodie M Richard, Camille Diez, Hala Alzaeem, Morgane Denus, Nicolas Cubedo, Thomas Delaunay, Emily Glendenning, Sarah Baxendale, Jean-Charles Liévens, Tanya T Whitfield, Tangui Maurice, Benjamin Delprat