日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

From Serendipity to Strategy: Rationalizing Molecular Glue Discovery and Proximity-Induced Pharmacology through Chemical Biology

从偶然发现到战略规划:通过化学生物学合理化分子胶的发现和邻近诱导药理学

Gray, Janine L; Xiao, Zhangping; Rogga, Vanessa V; Zhang, Xinyue; Tate, Edward W

Macrocyclic Peptide Probes for Immunomodulatory Protein CD59: Potent Modulators of Bacterial Toxin Activity and Antibody-Dependent Cytotoxicity

用于免疫调节蛋白CD59的大环肽探针:细菌毒素活性和抗体依赖性细胞毒性的有效调节剂

Bickel, Jasmine K; Ahmed, Ammar I S; Pidd, Aidan B; Morgan, Rhodri M; McAllister, Tom E; Horrell, Sam; Couves, Emma C; Nagaraj, Hemavathi; Bartlett, Edward J; El Omari, Kamel; Kawamura, Akane; Bubeck, Doryen; Tate, Edward W

Identification of Actionable Targeted Protein Degradation Effector Sites through Site-Specific Ligand Incorporation-Induced Proximity (SLIP)

通过位点特异性配体掺入诱导邻近性(SLIP)鉴定可操作的靶向蛋白质降解效应位点

Xiao, Zhangping; Gavriil, Efthymios S; Cao, Fangyuan; Zhang, Xinyue; Li, Stan Xiaogang; Kotelnikov, Sergei; Michalska, Patrycja; Marte, Friederike; Huang, Chloe; Lu, Yudi; Zhang, Yunxuan; Bernardini, Erika; Kozakov, Dima; Tate, Edward W

Affinity-based protein profiling of MDM2 inhibitor Navtemadlin

基于亲和力的MDM2抑制剂Navtemadlin的蛋白质谱分析

Date, Amrita; Wall, Archie; Zhang, Peiyu; Houghton, Jack W; Lu, Jianan; Thomas, Adam M; Kovačič, Tristan; Wilson, Andrew J; Tate, Edward W; Barnard, Anna

RAS/PI3K pathway mutations sensitise epithelial ovarian cancer cells to a PARP/NAMPT inhibitor combination.

RAS/PI3K通路突变使上皮性卵巢癌细胞对PARP/NAMPT抑制剂组合敏感。

Gruet Michael, Xu Yitao, An Lyutong, Ma Yurui, Balcells Cristina, Tyson Katie, Evangelista Laila C, Spear Sarah, Xu Yuewei, McKinney Flora, Babuta Julia, Bray Chandler, Wickremesinghe Chiharu, Siskos Alexandros P, Nijhuis Anke M, Tate Edward W, McNeish Iain A, Benito Adrian, Keun Hector C

Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1.

发现并验证一类靶向 RIPK1 的新型坏死性凋亡抑制剂

Soday Lior, Seripracharat Chotima, Gray Janine L, Luz André F S, Howard Ryan T, Singh Ravi, Burden Thomas J, Bernardini Erika, Mateus-Pinheiro Miguel, Petersen Jens, Gunnarsson Anders, Gunnarsson Jenny, Aagaard Anna, Sjögren Tove, Maslen Sarah, Bartlett Edward J, Iles Abigail F, Smith David M, Scott James S, Skehel Mark, Davis Andrew M, Ressurreição Ana S, Moreira Rui, Rodrigues Cecília M P, Shenoy Avinash R, Tate Edward W

Structure of Plasmodium vivaxN-myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy

间日疟原虫N-肉豆蔻酰转移酶及其抑制剂IMP-1088的结构:探索用于抗疟治疗的NMT抑制剂

Mendez, Alex; Bolling, Cydni; Taylor, Shane; Makumire, Stanley; Staker, Bart; Reers, Alexandra; Hammerson, Brad; Mayclin, Stephen J; Abendroth, Jan; Lorimer, Donald D; Edwards, Thomas E; Tate, Edward W; Subramanian, Sandhya; Bell, Andrew S; Myler, Peter J; Asojo, Oluwatoyin A; Chakafana, Graham

Identification of actionable targeted protein degradation effector sites through Site-specific Ligand Incorporation-induced Proximity (SLIP)

通过位点特异性配体掺入诱导邻近性(SLIP)鉴定可操作的靶向蛋白质降解效应位点

Xiao, Zhangping; Gavriil, Efthymios Spyridon; Cao, Fangyuan; Zhang, Xinyue; Li, Stan Xiaogang; Kotelnikov, Sergei; Michalska, Patrycja; Marte, Friederike; Huang, Chloe; Lu, Yudi; Zhang, Yunxuan; Bernardini, Erika; Kozakov, Dima; Tate, Edward W

GBP1 recruitment to actin-rich pedestals induced by extracellular Gram negative bacteria promotes pyroptosis

细胞外革兰氏阴性菌诱导的GBP1募集至富含肌动蛋白的基座,促进细胞焦亡。

Bennison, Daniel J; Chaudhary, Ishaan; Chaudhuri, Dharitri; Wong, Justin Chun Ngai; Biswas, Priyanka; Zhong, Qiyun; Kallemeijn, Wouter W; Guenot, Marianne; Talman, Arthur M; Frickel, Eva-Maria; Tate, Edward W; Visweswariah, Sandhya S; Frankel, Gad; Shenoy, Avinash R

Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders

ACBD6双等位基因变异会导致一种神经发育综合征,伴有进行性且复杂的运动障碍。

Kaiyrzhanov, Rauan; Rad, Aboulfazl; Lin, Sheng-Jia; Bertoli-Avella, Aida; Kallemeijn, Wouter W; Godwin, Annie; Zaki, Maha S; Huang, Kevin; Lau, Tracy; Petree, Cassidy; Efthymiou, Stephanie; Karimiani, Ehsan Ghayoor; Hempel, Maja; Normand, Elizabeth A; Rudnik-Schöneborn, Sabine; Schatz, Ulrich A; Baggelaar, Marc P; Ilyas, Muhammad; Sultan, Tipu; Alvi, Javeria Raza; Ganieva, Manizha; Fowler, Ben; Aanicai, Ruxandra; Tayfun, Gulsen Akay; Al Saman, Abdulaziz; Alswaid, Abdulrahman; Amiri, Nafise; Asilova, Nilufar; Shotelersuk, Vorasuk; Yeetong, Patra; Azam, Matloob; Babaei, Meisam; Monajemi, Gholamreza Bahrami; Mohammadi, Pouria; Samie, Saeed; Banu, Selina Husna; Pinto Basto, Jorge; Kortüm, Fanny; Bauer, Mislen; Bauer, Peter; Beetz, Christian; Garshasbi, Masoud; Issa, Awatif Hameed; Eyaid, Wafaa; Ahmed, Hind; Hashemi, Narges; Hassanpour, Kazem; Herman, Isabella; Ibrohimov, Sherozjon; Abdul-Majeed, Ban A; Imdad, Maria; Isrofilov, Maksudjon; Kaiyal, Qassem; Khan, Suliman; Kirmse, Brian; Koster, Janet; Lourenço, Charles Marques; Mitani, Tadahiro; Moldovan, Oana; Murphy, David; Najafi, Maryam; Pehlivan, Davut; Rocha, Maria Eugenia; Salpietro, Vincenzo; Schmidts, Miriam; Shalata, Adel; Mahroum, Mohammad; Talbeya, Jawabreh Kassem; Taylor, Robert W; Vazquez, Dayana; Vetro, Annalisa; Waterham, Hans R; Zaman, Mashaya; Schrader, Tina A; Chung, Wendy K; Guerrini, Renzo; Lupski, James R; Gleeson, Joseph; Suri, Mohnish; Jamshidi, Yalda; Bhatia, Kailash P; Vona, Barbara; Schrader, Michael; Severino, Mariasavina; Guille, Matthew; Tate, Edward W; Varshney, Gaurav K; Houlden, Henry; Maroofian, Reza