日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Model-Informed Drug Development for Daprodustat Supports the Design of Individualized Dosing Regimens in Chronic Kidney Disease Patients With Anemia

基于模型指导的达普司他药物开发支持为伴有贫血的慢性肾病患者设计个体化给药方案。

Mahar, Kelly M; Yang, Shuying; Johnson, Brendan; Visser, Sandra A G; van den Berg, Paul; van Noort, Martijn; Post, Teun M

Integrated Longitudinal Population Dose-Hemoglobin Response of Daprodustat Following Dose Titration in Patients With Anemia in Chronic Kidney Disease

达普司他治疗慢性肾病合并贫血患者剂量滴定后的纵向人群剂量-血红蛋白反应综合研究

Mahar, Kelly M; van Noort, Martijn; van den Berg, Paul; Yang, Shuying; Visser, Sandra A G; Post, Teun M

Tutorial on Conditional Simulations With a Tumor Size-Overall Survival Model to Support Oncology Drug Development

利用肿瘤大小-总生存期模型进行条件模拟以支持肿瘤药物研发的教程

Goulooze, Sebastiaan C; Muliaditan, Morris; Franzese, Richard C; Mantero, Alejandro; Visser, Sandra A G; Melhem, Murad; Post, Teun M; Rathi, Chetan; Struemper, Herbert

Development of a Joint Tumor Size-Overall Survival Modeling and Simulation Framework Supporting Oncology Development Decision-Making

开发联合肿瘤大小-总生存期建模和模拟框架,以支持肿瘤学发展决策

Struemper, Herbert; Rathi, Chetan; Muliaditan, Morris; Goulooze, Sebastiaan C; Franzese, Richard C; Mantero, Alejandro; Melhem, Murad; Post, Teun M; Visser, Sandra A G

Prognostic factors and prediction models for hospitalisation and all-cause mortality in adults presenting to primary care with a lower respiratory tract infection: a systematic review

成人下呼吸道感染患者就诊于基层医疗机构后,其住院和全因死亡率的预后因素及预测模型:系统评价

Rijk, Merijn H; Platteel, Tamara N; van den Berg, Teun M C; Geersing, Geert-Jan; Little, Paul; Rutten, Frans H; van Smeden, Maarten; Venekamp, Roderick P

Building an adaptive dose simulation framework to aid dose and schedule selection

构建自适应剂量模拟框架以辅助剂量和给药方案的选择

Hooijmaijers, Richard; Parasrampuria, Ridhi; Marostica, Eleonora; Ferron-Brady, Geraldine; Post, Teun M; Visser, Sandra A G

Longitudinal efficacy and safety modeling and simulation framework to aid dose selection of belantamab mafodotin for patients with multiple myeloma

用于辅助多发性骨髓瘤患者贝兰他单抗剂量选择的纵向疗效和安全性建模与模拟框架

Collins, Jon; van Noort, Martijn; Rathi, Chetan; Post, Teun M; Struemper, Herbert; Jewell, Roxanne C; Ferron-Brady, Geraldine

Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders

在神经发育障碍的人类模型中,自噬失衡会导致突触功能障碍。

Katrin Linda ,Elly I Lewerissa ,Anouk H A Verboven ,Michele Gabriele ,Monica Frega ,Teun M Klein Gunnewiek ,Lynn Devilee ,Edda Ulferts ,Marina Hommersom ,Astrid Oudakker ,Chantal Schoenmaker ,Hans van Bokhoven ,Dirk Schubert ,Giuseppe Testa ,David A Koolen ,Bert B A de Vries ,Nael Nadif Kasri

Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks

钙黏蛋白-13是人类干细胞衍生神经元网络中GABA能调节的关键调节因子

Mossink, Britt; van Rhijn, Jon-Ruben; Wang, Shan; Linda, Katrin; Vitale, Maria R; Zöller, Johanna E M; van Hugte, Eline J H; Bak, Jitske; Verboven, Anouk H A; Selten, Martijn; Negwer, Moritz; Latour, Brooke L; van der Werf, Ilse; Keller, Jason M; Klein Gunnewiek, Teun M; Schoenmaker, Chantal; Oudakker, Astrid; Anania, Alessia; Jansen, Sophie; Lesch, Klaus-Peter; Frega, Monica; van Bokhoven, Hans; Schubert, Dirk; Nadif Kasri, Nael

Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro

微电极阵列上的人类神经元网络是体外研究疾病特异性基因型-表型相关性的非常强大的工具

Britt Mossink, Anouk H A Verboven, Eline J H van Hugte, Teun M Klein Gunnewiek, Giulia Parodi, Katrin Linda, Chantal Schoenmaker, Tjitske Kleefstra, Tamas Kozicz, Hans van Bokhoven, Dirk Schubert, Nael Nadif Kasri, Monica Frega