日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of activators for SERCA2a for heart failure treatments

开发用于治疗心力衰竭的SERCA2a激活剂

Brinkmann, Marzena; Wong, Tsung-Yun Kent; Roopnarine, Osha; Yuen, Samantha L; Berg, Kaja; Cornea, Razvan L; Rebbeck, Robyn T; Thomas, David D; Aldrich, Courtney C

Large-scale high-throughput screen for cardiac ryanodine receptor targeted therapeutics

针对心脏兰尼碱受体靶向治疗药物的大规模高通量筛选

Nikolaienko, Roman; Bovo, Elisa; Solberg, Jonathan C; Brinkmann, Marzena; Treinen, Levy M; Thompson, Andrew R; Berg, Kaja; Thomas, David D; Thomas, Jennifer J; Bers, Donald M; Aldrich, Courtney C; Zima, Aleksey V; Cornea, Razvan L; Rebbeck, Robyn T

A piperidinyl amide compound enhances Ca(2+) signaling in cardiomyocytes by increasing activity of Ca(2+) pump

哌啶酰胺类化合物通过增强Ca²⁺泵的活性来增强心肌细胞中的Ca²⁺信号传导。

Bovo, Elisa; Nikolaienko, Roman; Yuen, Samantha L; Makarewich, Catherine A; Brinkmann, Marzena; Thomas, David D; Rebbeck, Robyn T; Zima, Aleksey V

A FRET assay to monitor different structural states of human β-cardiac myosin including the interacting-heads motif

利用FRET检测法监测人β-心肌肌球蛋白的不同结构状态,包括相互作用头部基序。

Goluguri, Rama Reddy; Guhathakurta, Piyali; Nandwani, Neha; Dawood, Aminah; Yokota, Seiji; Roopnarine, Osha; Thomas, David D; Ruppel, Kathleen M; Spudich, James A

Aurora A binds to the transactivation domain of c-Myc and recognizes the phosphorylated N-terminal degron motif

Aurora A 与 c-Myc 的转录激活结构域结合,并识别磷酸化的 N 端降解基序。

Joshi, Nidhi; Dunleavy, Katie M; Beel, Kaitlin M; Engel, Tiffany A; Thompson, Andrew R; John, Felix L; Thomas, David D; Levinson, Nicholas M

Kinetics insight into the roles of the N- and C-lobes of calmodulin in RyR1 channel regulation

动力学研究揭示了钙调蛋白N端和C端结构域在RyR1通道调控中的作用

Zhang, Jingyan; Treinen, Levy M; Mast, Skylar J; McCarthy, Megan R; Svensson, Bengt; Thomas, David D; Cornea, Razvan L

Tyrosine-Mediated Static and Dynamic Quenching of a Receptor Tyrosine Kinase Biosensor Reveals Inhibitor Binding Modes and Kinase Conformations.

酪氨酸介导的受体酪氨酸激酶生物传感器的静态和动态猝灭揭示了抑制剂结合模式和激酶构象

Baker Zachary D, Thompson Andrew R, Thomas David D, Levinson Nicholas M

Myosin relaxation states in skeletal muscle fibers of rats and mice: Effects of sex and adiposity

大鼠和小鼠骨骼肌纤维中肌球蛋白松弛状态:性别和肥胖的影响

Roloff, Zachery A; Phung, Lien A; Weyrauch, Luke A; Woods, Philip C; McMillin, Shawna L; Sullivan, Brian P; Barok, Rebecca; Zhang, Naixin; Murphy, Katherine A; O'Connell, Timothy D; Dougherty, Brendan J; Thomas, David D; Miller, Mark S; Lowe, Dawn A

Structural Dynamics of Protein Interactions Using Site-Directed Spin Labeling of Cysteines to Measure Distances and Rotational Dynamics with EPR Spectroscopy

利用半胱氨酸位点定向自旋标记结合电子顺磁共振波谱法测量距离和旋转动力学,研究蛋白质相互作用的结构动力学

Roopnarine, Osha; Thomas, David D

A FRET assay to quantitate levels of the human β-cardiac myosin interacting heads motif based on its near-atomic resolution structure.

基于接近原子分辨率结构的FRET检测方法,可定量分析人类β-心肌肌球蛋白相互作用头部基序的水平

Goluguri Rama Reddy, Guhathakurta Piyali, Nandwani Neha, Dawood Aminah, Yakota Seiji, Roopnarine Osha, Thomas David D, Spudich James A, Ruppel Kathleen M