日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Engineering of anticancer human immunoglobulin A equipped with albumin for enhanced plasma half-life

通过工程改造,将抗癌人免疫球蛋白A与白蛋白连接,以延长其血浆半衰期。

Simone Mester ,Chilam Chan ,Marta Lustig ,Stian Foss ,J H Marco Jansen ,Marie Leangen Herigstad ,Mitchell Evers ,Jeannette Nilsen ,Karli R Reiding ,J Mirjam A Damen ,Renate Burger ,Algirdas Grevys ,Bjørn Dalhus ,Thomas Valerius ,Inger Sandlie ,Jeanette H W Leusen ,Jan Terje Andersen

Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

人IgG Fc工程改造可增强血浆半衰期、黏膜分布并杀灭癌细胞和细菌

Stian Foss ,Siri A Sakya # ,Leire Aguinagalde # ,Marta Lustig # ,Jutamas Shaughnessy # ,Ana Rita Cruz # ,Lisette Scheepmaker # ,Line Mathiesen ,Fulgencio Ruso-Julve ,Aina Karen Anthi ,Torleif Tollefsrud Gjølberg ,Simone Mester ,Malin Bern ,Mitchell Evers ,Diane B Bratlie ,Terje E Michaelsen ,Tilman Schlothauer ,Devin Sok ,Jayanta Bhattacharya ,Jeanette Leusen ,Thomas Valerius ,Sanjay Ram ,Suzan H M Rooijakkers ,Inger Sandlie ,Jan Terje Andersen

Human Tumor-Associated Macrophages and Neutrophils Regulate Antitumor Antibody Efficacy through Lethal and Sublethal Trogocytosis

人类肿瘤相关巨噬细胞和中性粒细胞通过致死性和亚致死性吞噬作用调节抗肿瘤抗体的疗效

Sunil Singhal ,Abhishek S Rao ,Jason Stadanlick ,Kyle Bruns ,Neil T Sullivan ,Andres Bermudez ,Adam Honig-Frand ,Ryan Krouse ,Sachinthani Arambepola ,Emily Guo ,Edmund K Moon ,George Georgiou ,Thomas Valerius ,Steven M Albelda ,Evgeniy B Eruslanov

Sialylation inhibition improves macrophage mediated tumor cell phagocytosis of breast cancer cells triggered by therapeutic antibodies of different isotypes

唾液酸化抑制可增强巨噬细胞介导的、由不同亚型治疗性抗体触发的乳腺癌细胞吞噬作用。

Marta Lustig ,Christoph Hahn ,Marie Leangen Herigstad ,Jan Terje Andersen ,Jeanette H W Leusen ,Renate Burger ,Thomas Valerius

Disruption of the sialic acid/Siglec-9 axis improves antibody-mediated neutrophil cytotoxicity towards tumor cells

唾液酸/Siglec-9 轴的破坏可增强抗体介导的中性粒细胞对肿瘤细胞的细胞毒性

Marta Lustig, Chilam Chan, J H Marco Jansen, Maria Bräutigam, Max A Kölling, Carina Lynn Gehlert, Niklas Baumann, Simone Mester, Stian Foss, Jan Terje Andersen, Lorenz Bastian, Peter Sondermann, Matthias Peipp, Renate Burger, Jeanette H W Leusen, Thomas Valerius

Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9

肿瘤细胞上的唾液酸通过抑制受体 Siglec-7 和 Siglec-9 调节中性粒细胞的 IgA 疗法

Chilam Chan, Marta Lustig, J H Marco Jansen, Laura Garcia Villagrasa, Leon Raymakers, Lois A Daamen, Thomas Valerius, Geert van Tetering, Jeanette H W Leusen

Venetoclax enhances the efficacy of therapeutic antibodies in B-cell malignancies by augmenting tumor cell phagocytosis

维奈托克通过增强肿瘤细胞吞噬作用来提高治疗性抗体在B细胞恶性肿瘤中的疗效。

Fotini Vogiatzi ,Julia Heymann ,Kristina Müller ,Dorothee Winterberg ,Aneta Drakul ,Thies Rösner ,Lennart Lenk ,Michelle Heib ,Carina Lynn Gehlert ,Gunnar Cario ,Martin Schrappe ,Alexander Claviez ,Beat Bornhauser ,Jean-Pierre Bourquin ,Simon Bomken ,Dieter Adam ,Fabian-Simon Frielitz ,Britta Maecker-Kolhoff ,Martin Stanulla ,Thomas Valerius ,Matthias Peipp ,Christian Kellner ,Denis M Schewe

Dual Fc optimization to increase the cytotoxic activity of a CD19-targeting antibody

双Fc优化以提高靶向CD19抗体的细胞毒活性

Carina Lynn Gehlert ,Pegah Rahmati ,Ammelie Svea Boje ,Dorothee Winterberg ,Steffen Krohn ,Thomas Theocharis ,Elisa Cappuzzello ,Anja Lux ,Falk Nimmerjahn ,Ralf J Ludwig ,Marta Lustig ,Thies Rösner ,Thomas Valerius ,Denis Martin Schewe ,Christian Kellner ,Katja Klausz ,Matthias Peipp

Augmented antibody-based anticancer therapeutics boost neutrophil cytotoxicity

增强型抗体抗癌疗法增强中性粒细胞的细胞毒性

Niels Heemskerk, Mandy Gruijs, A Robin Temming, Marieke H Heineke, Dennis Y Gout, Tessa Hellingman, Cornelis W Tuk, Paula J Winter, Suzanne Lissenberg-Thunnissen, Arthur Eh Bentlage, Marco de Donatis, Marijn Bögels, Thies Rösner, Thomas Valerius, Jantine E Bakema, Gestur Vidarsson, Marjolein van Egm

Anti-GD2 IgA kills tumors by neutrophils without antibody-associated pain in the preclinical treatment of high-risk neuroblastoma

在高危神经母细胞瘤的临床前治疗中,抗 GD2 IgA 通过中性粒细胞杀死肿瘤,且不会引起抗体相关疼痛

Mitchell Evers, Marjolein Stip #, Kaylee Keller #, Hanneke Willemen #, Maaike Nederend, Marco Jansen, Chilam Chan, Kevin Budding, Stefan Nierkens, Thomas Valerius, Friederike Meyer-Wentrup, Niels Eijkelkamp #, Jeanette Leusen #