日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice

硬脂酰辅酶A去饱和酶抑制剂可使突变型Gba1帕金森小鼠的脑脂质饱和度、α-突触核蛋白稳态和运动功能恢复正常。

Silke Nuber ,Harrison Hsiang ,Esra'a Keewan ,Tim E Moors ,Sydney J Reitz ,Anupama Tiwari ,Gary Ph Ho ,Elena Su ,Wolf Hahn ,Marie-Alexandre Adom ,Riddhima Pathak ,Matthew Blizzard ,Sangjune Kim ,Han Seok Ko ,Xiaoqun Zhang ,Per Svenningsson ,Dennis J Selkoe ,Saranna Fanning

Altered TFEB subcellular localization in nigral neurons of subjects with incidental, sporadic and GBA-related Lewy body diseases

偶然、散发和 GBA 相关路易体疾病患者的黑质神经元中 TFEB 亚细胞定位发生改变

Tim E Moors, Martino L Morella, Cesc Bertran-Cobo, Hanneke Geut, Vinod Udayar, Evelien Timmermans-Huisman, Angela M T Ingrassia, John J P Brevé, John G J M Bol, Vincenzo Bonifati, Ravi Jagasia, Wilma D J van de Berg

Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes

G51D 和 3D 小鼠的产生表明 α-突触核蛋白四聚体-单体比率降低会促进帕金森病表型

Silke Nuber, Xiaoqun Zhang, Thomas D McCaffery, Tim E Moors, Marie-Alexandre Adom, Wolf N Hahn, Dylan Martin, Maria Ericsson, Arati Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J Selkoe

Increased palmitoylation improves estrogen receptor alpha-dependent hippocampal synaptic deficits in a mouse model of synucleinopathy

增加棕榈酰化可改善突触核蛋白病小鼠模型中雌激素受体 α 依赖性海马突触缺陷

Tim E Moors, Shaomin Li, Thomas D McCaffery, Gary P H Ho, Pascal A Bechade, Luu N Pham, Maria Ericsson, Silke Nuber

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity

动态生理性 α-突触核蛋白 S129 磷酸化由神经元活动驱动

Nagendran Ramalingam, Shan-Xue Jin #, Tim E Moors #, Luis Fonseca-Ornelas, Kazuma Shimanaka, Shi Lei, Hugh P Cam, Aurelia Hays Watson, Lisa Brontesi, Lai Ding, Dinc Yasat Hacibaloglu, Haiyang Jiang, Se Joon Choi, Ellen Kanter, Lei Liu, Tim Bartels, Silke Nuber, David Sulzer, Eugene V Mosharov, Weish

Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies

对 α-突触核蛋白人脑蛋白质形式的多平台定量分析表明突触核蛋白病的疾病特异性生化特征

Tim E Moors, Daniel Mona, Stefan Luehe, Gonzalo Duran-Pacheco, Liz Spycher, Olaf Mundigl, Klaus Kaluza, Sylwia Huber, Melanie N Hug, Thomas Kremer, Mirko Ritter, Sebastian Dziadek, Gregor Dernick, Wilma D J van de Berg, Markus Britschgi

The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy

多色 STED 显微镜显示帕金森病患者大脑中 α-突触核蛋白蛋白质形式的亚细胞排列

Tim E Moors, Christina A Maat, Daniel Niedieker, Daniel Mona, Dennis Petersen, Evelien Timmermans-Huisman, Jeroen Kole, Samir F El-Mashtoly, Liz Spycher, Wagner Zago, Robin Barbour, Olaf Mundigl, Klaus Kaluza, Sylwia Huber, Melanie N Hug, Thomas Kremer, Mirko Ritter, Sebastian Dziadek, Jeroen J G Ge

Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice

野生型 GBA1 可增加 α-突触核蛋白四聚体-单体比率,减少富含脂质的聚集体,并减轻小鼠的运动和认知缺陷

Kelly E Glajch, Tim E Moors, Yi Chen, Pascal A Bechade, Alice Y Nam, Molly M Rajsombath, Thomas D McCaffery, Ulf Dettmer, Andreas Weihofen, Warren D Hirst, Dennis J Selkoe, Silke Nuber