Timothy M Horton相关文献与解析，生知库 | 链接生命科学的每一步

Timothy M Horton, Vandana Sundaram, Christine Hye-Jin Lee, Kathleen Hornbacker, Aidan Van Vleck, Kaisha N Benjamin, Allison Zemek, Teri A Longacre, Pamela L Kunz, Justin P Annes

神经

肿瘤

IHC

Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization

通过多维化合物优化生成高效的 DYRK1A 依赖性人类 β 细胞复制诱导剂

期刊:Bioorganic & Medicinal Chemistry

影响因子:3.3

doi:10.1016/j.bmc.2019.115193

Paul A Allegretti, Timothy M Horton, Yassan Abdolazimi, Hannah P Moeller, Benjamin Yeh, Matthew Caffet, Guillermina Michel, Mark Smith, Justin P Annes

Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic β Cells

锌螯合小分子优先在胰腺 β 细胞内积累并发挥作用

期刊:Cell Chemical Biology

影响因子:6.6

doi:10.1016/j.chembiol.2018.10.019

Timothy M Horton, Paul A Allegretti, Sooyeon Lee, Hannah P Moeller, Mark Smith, Justin P Annes

CC-401 Promotes β-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition

CC-401 通过 DYRK1A/B 抑制的多效性后果促进 β 细胞复制

期刊:Endocrinology

影响因子:3.8

doi:10.1210/en.2018-00083

Yassan Abdolazimi, Zhengshan Zhao, Sooyeon Lee, Haixia Xu, Paul Allegretti, Timothy M Horton, Benjamin Yeh, Hannah P Moeller, Robert J Nichols, David McCutcheon, Aryaman Shalizi, Mark Smith, Neali A Armstrong, Justin P Annes

Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding

通过共价反应或氧化 ZAP-70 和 Syk 串联 SH2 结构域中的半胱氨酸残基进行修饰可以阻断磷酸肽结合

期刊:Biochemical Journal

影响因子:4.4

doi:10.1042/BJ20140793

Patrick R Visperas, Jonathan A Winger, Timothy M Horton, Neel H Shah, Diane J Aum, Alyssa Tao, Tiago Barros, Qingrong Yan, Christopher G Wilson, Michelle R Arkin, Arthur Weiss, John Kuriyan

表观遗传

发表日期：2015

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Novel Pathogenic De Novo INS p.T97P Variant Presenting With Severe Neonatal DKA

新型致病性新生 INS p.T97P 变异导致重症新生儿 DKA

Protocol for determining zinc-dependent β cell-selective small-molecule delivery in mouse pancreas

确定小鼠胰腺中锌依赖性β细胞选择性小分子输送的方案

PAM staining intensity of primary neuroendocrine neoplasms is a potential prognostic biomarker

原发性神经内分泌肿瘤的 PAM 染色强度是潜在的预后生物标志物

Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization

通过多维化合物优化生成高效的 DYRK1A 依赖性人类 β 细胞复制诱导剂

Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic β Cells

锌螯合小分子优先在胰腺 β 细胞内积累并发挥作用

CC-401 Promotes β-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition

CC-401 通过 DYRK1A/B 抑制的多效性后果促进 β 细胞复制

Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding

通过共价反应或氧化 ZAP-70 和 Syk 串联 SH2 结构域中的半胱氨酸残基进行修饰可以阻断磷酸肽结合