Timothy M Shaver相关文献与解析，生知库 | 链接生命科学的每一步

Lindsay N Redman-Rivera, Timothy M Shaver #, Hailing Jin #, Clayton B Marshall, Johanna M Schafer, Quanhu Sheng, Rachel A Hongo, Kathryn E Beckermann, Ferrin C Wheeler, Brian D Lehmann, Jennifer A Pietenpol

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发表日期：2021

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Identification of Targetable Recurrent MAP3K8 Rearrangements in Melanomas Lacking Known Driver Mutations

在缺乏已知驱动突变的黑色素瘤中识别可靶向的复发性 MAP3K8 重排

期刊:Molecular Cancer Research

影响因子:4.1

doi:10.1158/1541-7786.MCR-19-0257

Brian D Lehmann, Timothy M Shaver, Douglas B Johnson, Zhu Li, Paula I Gonzalez-Ericsson, Violeta Sánchez, Yu Shyr, Melinda E Sanders, Jennifer A Pietenpol

p73 regulates epidermal wound healing and induced keratinocyte programming

p73 调节表皮伤口愈合并诱导角质形成细胞编程

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0218458

J Scott Beeler, Clayton B Marshall, Paula I Gonzalez-Ericsson, Timothy M Shaver, Gabriela L Santos Guasch, Spencer T Lea, Kimberly N Johnson, Hailing Jin, Bryan J Venters, Melinda E Sanders, Jennifer A Pietenpol

A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Response Gene Mutations, TNBC Subtype, AR Status, and Ki67

一项针对 II/III 期三阴性乳腺癌 (TNBC) 患者进行顺铂、紫杉醇联合或不联合依维莫司治疗的随机 II 期新辅助治疗研究：治疗反应和长期结果与 DNA 损伤反应基因突变频率增加、TNBC 亚型、AR 状态和 Ki67 相关

期刊:Clinical Cancer Research

影响因子:10

doi:10.1158/1078-0432.CCR-16-3055

Bojana Jovanović, Ingrid A Mayer, Erica L Mayer, Vandana G Abramson, Aditya Bardia, Melinda E Sanders, M Gabriela Kuba, Monica V Estrada, J Scott Beeler, Timothy M Shaver, Kimberly C Johnson, Violeta Sanchez, Jennifer M Rosenbluth, Patrick M Dillon, Andres Forero-Torres, Jenny C Chang, Ingrid M Mesz

TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2

TCF7L1通过诱导LCN2，在不依赖β-catenin的情况下促进皮肤肿瘤发生。

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.23242

Amy T Ku ，Timothy M Shaver ，Ajay S Rao ，Jeffrey M Howard ，Christine N Rodriguez ，Qi Miao ，Gloria Garcia ，Diep Le ，Diane Yang ，Malgorzata Borowiak ，Daniel N Cohen ，Vida Chitsazzadeh ，Abdul H Diwan ，Kenneth Y Tsai ，Hoang Nguyen

EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib

EGFR 激酶结构域重复 (EGFR-KDD) 是肺癌中一种新的致癌驱动因素，对阿法替尼具有临床反应

期刊:Cancer Discovery

影响因子:29.7

doi:10.1158/2159-8290.CD-15-0654

Jean-Nicolas Gallant, Jonathan H Sheehan, Timothy M Shaver, Mark Bailey, Doron Lipson, Raghu Chandramohan, Monica Red Brewer, Sally J York, Mark G Kris, Jennifer A Pietenpol, Marc Ladanyi, Vincent A Miller, Siraj M Ali, Jens Meiler, Christine M Lovly

Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2

Tcf3 通过调节脂质运载蛋白 2 促进细胞迁移和伤口修复

期刊:Nature Communications

影响因子:14.7

doi:10.1038/ncomms5088

Qi Miao, Amy T Ku, Yudai Nishino, Jeffrey M Howard, Ajay S Rao, Timothy M Shaver, Gloria E Garcia, Diep N Le, Kristen L Karlin, Thomas F Westbrook, Valeria Poli, Hoang Nguyen

Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome)

小鼠中 Porcn 的缺失会导致多种发育缺陷，并模拟人类局灶性真皮发育不全（Goltz 综合征）

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0032331

Wei Liu, Timothy M Shaver, Alfred Balasa, M Cecilia Ljungberg, Xiaoling Wang, Shu Wen, Hoang Nguyen, Ignatia B Van den Veyver

Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11

器官特异性羧酸酯酶分析确定小肠和肾脏是激活抗癌前药 CPT-11 的主要因素

期刊:Biochemical Pharmacology

影响因子:5.3

doi:10.1016/j.bcp.2010.09.001

M Jason Hatfield, Lyudmila Tsurkan, Michael Garrett, Timothy M Shaver, Janice L Hyatt, Carol C Edwards, Latorya D Hicks, Philip M Potter

Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes

非整倍体的获得驱动突变 p53 相关功能获得表型

Identification of Targetable Recurrent MAP3K8 Rearrangements in Melanomas Lacking Known Driver Mutations

在缺乏已知驱动突变的黑色素瘤中识别可靶向的复发性 MAP3K8 重排

p73 regulates epidermal wound healing and induced keratinocyte programming

p73 调节表皮伤口愈合并诱导角质形成细胞编程

A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Response Gene Mutations, TNBC Subtype, AR Status, and Ki67

一项针对 II/III 期三阴性乳腺癌 (TNBC) 患者进行顺铂、紫杉醇联合或不联合依维莫司治疗的随机 II 期新辅助治疗研究：治疗反应和长期结果与 DNA 损伤反应基因突变频率增加、TNBC 亚型、AR 状态和 Ki67 相关

TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2

TCF7L1通过诱导LCN2，在不依赖β-catenin的情况下促进皮肤肿瘤发生。

EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib

EGFR 激酶结构域重复 (EGFR-KDD) 是肺癌中一种新的致癌驱动因素，对阿法替尼具有临床反应

Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2

Tcf3 通过调节脂质运载蛋白 2 促进细胞迁移和伤口修复

Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome)

小鼠中 Porcn 的缺失会导致多种发育缺陷，并模拟人类局灶性真皮发育不全（Goltz 综合征）

Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11

器官特异性羧酸酯酶分析确定小肠和肾脏是激活抗癌前药 CPT-11 的主要因素