日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia

异二聚体细胞因子受体的不同组装体调控白血病干细胞程序

Winnie L Kan # ,Urmi Dhagat # ,Kerstin B Kaufmann # ,Timothy R Hercus # ,Tracy L Nero # ,Andy G X Zeng # ,John Toubia # ,Emma F Barry ,Sophie E Broughton ,Guillermo A Gomez ,Brooks A Benard ,Mara Dottore ,Karen S Cheung Tung Shing ,Héléna Boutzen ,Saumya E Samaraweera ,Kaylene J Simpson ,Liqing Jin ,Gregory J Goodall ,C Glenn Begley ,Daniel Thomas ,Paul G Ekert ,Denis Tvorogov ,Richard J D'Andrea ,John E Dick ,Michael W Parker ,Angel F Lopez

Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models

阻断人类 GM-CSF、IL-5 和 IL-3 受体的共同 β 亚基可显著降低 ARDS 模型中的过度炎症

Hao Wang, Damon J Tumes, Timothy R Hercus, K H Yip, Christian Aloe, Ross Vlahos, Angel F Lopez, Nick Wilson, Catherine M Owczarek, Steven Bozinovski

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

IL-3 受体 N 端结构域在细胞信号传导中的双重作用

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Winnie L Kan, Emma F Barry, Mara Dottore, Karen S Cheung Tung Shing, Craig J Morton, Urmi Dhagat, Matthew P Hardy, Nicholas J Wilson, Matthew T Downton, Christine Schieber, Timothy P Hughes, Angel F Lopez, Michael W Parker

Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis

JAK 活化环磷酸化的积累与骨髓纤维化中的 I 型 JAK 抑制剂戒断综合征有关

Denis Tvorogov, Daniel Thomas, Nicholas P D Liau, Mara Dottore, Emma F Barry, Maya Lathi, Winnie L Kan, Timothy R Hercus, Frank Stomski, Timothy P Hughes, Vinay Tergaonkar, Michael W Parker, David M Ross, Ravindra Majeti, Jeffrey J Babon, Angel F Lopez

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities

人类 GM-CSF 自身抗体抑制 GM-CSF 的机制提示了新的治疗机会

Urmi Dhagat, Timothy R Hercus, Sophie E Broughton, Tracy L Nero, Karen S Cheung Tung Shing, Emma F Barry, Christy A Thomson, Steve Bryson, Emil F Pai, Barbara J McClure, John W Schrader, Angel F Lopez, Michael W Parker

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors

CSL311 是一种新型、强效的治疗性单克隆抗体,用于治疗由 IL-3、GM-CSF 和 IL-5 受体的共同 β 链介导的疾病。

Con Panousis ,Urmi Dhagat ,Kirsten M Edwards ,Veronika Rayzman ,Matthew P Hardy ,Hal Braley ,Gail M Gauvreau ,Timothy R Hercus ,Steven Smith ,Roma Sehmi ,Laura McMillan ,Mara Dottore ,Barbara J McClure ,Louis J Fabri ,Gino Vairo ,Angel F Lopez ,Michael W Parker ,Andrew D Nash ,Nicholas J Wilson ,Michael J Wilson ,Catherine M Owczarek

GM-CSF signalling blockade and chemotherapeutic agents act in concert to inhibit the function of myeloid-derived suppressor cells in vitro

GM-CSF 信号阻断和化疗药物协同作用,体外抑制髓系抑制细胞的功能

Tessa Gargett, Susan N Christo, Timothy R Hercus, Nazim Abbas, Nimit Singhal, Angel F Lopez, Michael P Brown

Characterization of pathogenic human monoclonal autoantibodies against GM-CSF

抗 GM-CSF 的致病性人类单克隆自身抗体的表征

Yanni Wang, Christy A Thomson, Lenka L Allan, Linda M Jackson, Melanie Olson, Timothy R Hercus, Tracy L Nero, Amanda Turner, Michael W Parker, Angel L Lopez, Thomas K Waddell, Gary P Anderson, John A Hamilton, John W Schrader