日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

XPO1 R749Q Mutations Co-occur with POLE Mutations in Cancer and Can Be Targeted to Overcome Chemoresistance

XPO1 R749Q 突变与 POLE 突变在癌症中同时发生,可作为克服化疗耐药性的靶点。

Totiger, Tulasigeri M; Chiraphapphaiboon, Wannasiri; Baca, Yasmine; Chaudhry, Sana; Notti, Ryan Q; Montoya, Skye; Chojnacka, Monika; Gaidosh, Gabriel; Afaghani, Jumana; Affer, Maurizio; Armstrong, Christopher; Kavanaugh, Paul M; Karaca, Efe; Zabroski, Jenna; Lewis, Michael; Maye, Alyssa; Jahn, Jacob; Soni, Rajesh K; Bilbao, Daniel; Walker, Phil; Elliott, Andrew; Lou, Emil; El-Deiry, Wafik S; Rodriguez, Jose Antonio; Nguyen, Hai Dang; Taylor, Justin

Functional cure with single agent olutasidenib in relapsed IDH1/NPM1 co-mutated AML

单药奥鲁西地尼治疗复发性IDH1/NPM1共突变急性髓系白血病可达到功能性治愈。

Watts, Justin; Nong, Tiffany; Micin, Katarina; Soong, Deborah; Madarang, Ellen; Affer, Maurizio; Mehra, Shefali; Lesmes, Jessica Alvarez; Chapman, Jennifer; Zhou, Yi; Thomassen, Amber; Bradley, Terrence; Totiger, Tulasigeri; Swords, Ronan; Taylor, Justin

CREB Drives Acinar to Ductal Cells Reprogramming and Promotes Pancreatic Cancer Progression in Preclinical Models of Alcoholic Pancreatitis.

CREB 驱动腺泡细胞向导管细胞重编程,并在酒精性胰腺炎的临床前模型中促进胰腺癌的进展。

Srinivasan Supriya, Mehra Siddharth, Jinka Sudhakar, Bianchi Anna, Singh Samara, Dosch Austin R, Amirian Haleh, Krishnamoorthy Varunkumar, De Castro Silva Iago, Patel Manan, Box Edmond Worley Iii, Garrido Vanessa, Totiger Tulasigeri M, Zhou Zhiqun, Ban Yuguang, Datta Jashodeep, VanSaun Michael, Merchant Nipun, Nagathihalli Nagaraj S

Co-targeting menin and LSD1 dismantles oncogenic programs and restores differentiation in MLL-rearranged AML

联合靶向menin和LSD1可瓦解致癌程序并恢复MLL重排AML中的分化

Tayari, Mina M; Dos Santos, Helena Gomes; Beckedorff, Felipe; Totiger, Tulasigeri; Mookhtiar, Adnan; Kingham, Anna Lesley; Lavezzo, Guilherme Miura; Martin, Gloria Mas; Huang, Hsuan-Ting; Karaca, Efe; Bilbao, Daniel; Taylor, Justin; Shiekhattar, Ramin; Watts, Justin M

Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity

CARM1 的酪氨酸磷酸化可促进其酶活性并改变其靶向特异性

Hidehiro Itonaga, Adnan K Mookhtiar, Sarah M Greenblatt, Fan Liu, Concepcion Martinez, Daniel Bilbao, Masai Rains, Pierre-Jacques Hamard, Jun Sun, Afoma C Umeano, Stephanie Duffort, Chuan Chen, Na Man, Gloria Mas, Luca Tottone, Tulasigeri Totiger, Terrence Bradley, Justin Taylor, Stephan Schürer, St

Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition

SF3B1 突变体改变的 RNA 输出赋予对核输出抑制的敏感性

Sana Chaudhry, Felipe Beckedorff, Shaista Shabbir Jasdanwala, Tulasigeri M Totiger, Maurizio Affer, Abimbola Eunice Lawal, Skye Montoya, Francesco Tamiro, Olivia Tonini, Alexandra Chirino, Andrew Adams, Anya K Sondhi, Stephen Noudali, Alyssa Mauri Cornista, Miah Nicholls, Jumana Afaghani, Paola Roba

Protective Effect of Knee Postoperative Fluid on Oxidative-Induced Damage in Human Knee Articular Chondrocytes

膝关节术后输液对人膝关节软骨细胞氧化损伤的保护作用

Giordo, Roberta; Tulasigeri Totiger, Smitha; Caggiari, Gianfilippo; Cossu, Annalisa; Manunta, Andrea Fabio; Posadino, Anna Maria; Pintus, Gianfranco

Potent, Selective, and Orally Bioavailable Quinazoline-Based STK17A/B Dual Inhibitors

高效、选择性强且口服生物利用度高的喹唑啉类STK17A/B双重抑制剂

Chaudhry, Sana; Castro, Jesus R; Totiger, Tulasigeri M; Afaghani, Jumana; Khurshid, Rabia; Nicholls, Miah; Zhang, Ziming; Schürer, Stephan C; Shah, Ashish; Taylor, Justin; Feng, Yangbo

CREB activation drives acinar to ductal reprogramming and promote pancreatic cancer progression in animal models of alcoholic chronic pancreatitis

CREB 激活驱动腺泡至导管重编程并促进酒精性慢性胰腺炎动物模型中的胰腺癌进展

Supriya Srinivasan, Siddharth Mehra, Anna Bianchi, Samara Singh, Austin R Dosch, Haleh Amirian, Sudhakar Jinka, Varunkumar Krishnamoorthy, Iago De Castro Silva, Edmond Worley Iii Box, Vanessa Garrido, Tulasigeri M Totiger, Zhiqun Zhou, Yuguang Ban, Jashodeep Datta, Michael VanSaun, Nipun Merchant, N

Tracking the evolution of therapy-related myeloid neoplasms using chemotherapy signatures

利用化疗特征追踪治疗相关髓系肿瘤的演变

Diamond, Benjamin; Ziccheddu, Bachisio; Maclachlan, Kylee; Taylor, Justin; Boyle, Eileen; Ossa, Juan Arango; Jahn, Jacob; Affer, Maurizio; Totiger, Tulasigeri M; Coffey, David; Chandhok, Namrata; Watts, Justin; Cimmino, Luisa; Lu, Sydney X; Bolli, Niccolò; Bolton, Kelly; Landau, Heather; Park, Jae H; Ganesh, Karuna; McPherson, Andrew; Sekeres, Mikkael A; Lesokhin, Alexander; Chung, David J; Zhang, Yanming; Ho, Caleb; Roshal, Mikhail; Tyner, Jeffrey; Nimer, Stephen; Papaemmanuil, Elli; Usmani, Saad; Morgan, Gareth; Landgren, Ola; Maura, Francesco